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Charing Cross hospital[Affiliation] Publications | LitMetric

4,357 results match your criteria: "Charing Cross hospital[Affiliation]"

Background And Objective: Randomised data on patient-reported outcomes (PROs) for stereotactic body radiotherapy (SBRT) and prostatectomy in localised prostate cancer are lacking. PACE-A compared patient-reported health-related quality of life after SBRT with that after prostatectomy.

Methods: PACE is a phase 3 open-label, randomised controlled trial.

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Patient Selection, Outcome, and Unhappy Patients in Rhinoplasty.

Facial Plast Surg

September 2024

Department of Otorhinolaryngology, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland.

This article discusses the process of patient selection for rhinoplasties and the many different psychological aspects that come into play. It is important to identify the warning signs and apply a multidisciplinary approach to the surgeons practice, in collaboration with specialist rhinoplasty psychologists. Patients' motivations and surgeon factors are also discussed, as this can lead to unhappy and unsatisfactory postoperative outcomes.

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Utilising accessible and reproducible neurological assessments in clinical studies: Insights from use of the Neurological Impairment Scale in the multi-centre COVID-CNS study.

Clin Med (Lond)

September 2024

Infection Neuroscience Laboratory, Institute of Infection, Veterinary and Ecological Science, University of Liverpool, NIHR HPRU for Emerging and Zoonotic Infection, Liverpool, UK.

Reproducible and standardised neurological assessment scales are important in quantifying research outcomes. These scales are often performed by non-neurologists and/or non-clinicians and must be robust, quantifiable, reproducible and comparable to a neurologist's assessment. COVID-CNS is a multi-centre study which utilised the Neurological Impairment Scale (NIS) as a core assessment tool in studying neurological outcomes following COVID-19 infection.

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Background: Atrial fibrillation (AF) can be known before the stroke (KAF) or be newly detected after stroke (AFDAS). It is unknown whether the outcome of stroke differs between KAF and AFDAS. We performed a propensity-matched analysis to investigate the outcome of patients with AFDAS and their counterparts with KAF.

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Background And Aims: Short-term mortality in alcohol-related hepatitis (AH) is high, and no current therapy results in durable benefit. A role for interleukin (IL)-1β has been demonstrated in the pathogenesis of alcohol-induced steatohepatitis. This study explored the safety and efficacy of canakinumab (CAN), a monoclonal antibody targeting IL-1β, in the treatment of patients with AH.

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Article Synopsis
  • Peripheral nerve injuries (PNIs) present complex challenges for reconstruction, with vascularised (VNGs) and non-vascularised nerve grafts (NVNGs) being common treatment options; this review aims to compare their clinical and laboratory outcomes.
  • A systematic literature search identified seven clinical and 34 laboratory studies, showing that VNGs generally favored recovery in sensory and motor functions, and showed better lab results like reduced muscular atrophy and enhanced nerve regeneration.
  • Despite the indications that VNGs may be superior, the evidence quality was low and varied, meaning more robust clinical trials are needed to strengthen these findings.
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US Markers and Necroinflammation, Steatosis, and Fibrosis in Metabolic Dysfunction-associated Steatotic Liver Disease: The iLEAD Study.

Radiology

August 2024

From the Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan (K. Sugimoto, T.I.); Department of Gastroenterology and Hepatology, International University of Health and Welfare, Sanno Hospital, Tokyo, Japan (F.M.); Department of Radiology, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Université de Paris, Clichy, France (M.D.B., V.V.); Departments of Internal Medicine 1, Medicine 1, Gastroenterology, Endocrinology, and Pneumology, Erlangen University Hospital, Erlangen, Germany (D.J., D.S.); Division of Gastroenterology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany (V.B., T.K.); Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (E.G.G.); Department of Radiology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.K., H.G.); Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (B.I.C.); Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.N., H.I.); Department of Radiology, University of Washington, Seattle, Wash (T.J.D.); Rocky Vista University, Ivins, Utah (J.G.); Department of Radiology, Seoul National University Hospital, Seoul, Korea (D.H.L., J.Y.L.); Department of Ultrasound in Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China (Y.Z., P.H.); Department of Ultrasound, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (J.Z.); Department of Imaging, Charing Cross Hospital, Imperial College London and Imperial College Healthcare NHS Trust, London, England (A.L.); Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (X.X.); Department of Radiology, Northeastern Ohio Medical University, Rootstown, Ohio (R.G.B.); Southwoods Imaging, Youngstown, Ohio (R.G.B.); Division of Internal-Surgical Ultrasound, Department of Radiologic, Oncologic, and Anatomic-Pathologic Science, Polyclinic Umberto I, Sapienza University of Rome, Rome, Italy (V.C.); Department of Clinical-Surgical, Diagnostic, and Pediatric Sciences, Medical School, University of Pavia, Pavia, Italy (G.F.); Center for Data Science, Juntendo University, Tokyo, Japan (K. Sakamaki); and Department of Pathology, Kurume University School of Medicine, Kurume, Japan (M.K., H.Y.).

Background Attenuation coefficient (AC) and shear-wave speed (SWS) are established US markers for assessing patients with metabolic dysfunction-associated steatotic liver disease (MASLD), while shear-wave dispersion slope (DS) is not. Purpose To assess the relationship between the multiparametric US imaging markers DS, AC, and SWS and liver histopathologic necroinflammation in patients with MASLD. Materials and Methods This international multicenter prospective study enrolled consecutive patients with biopsy-proven MASLD between June 2019 and March 2023.

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Objective: To evaluate current usage and barriers of electronic consent (e-consent) implementation in neurosurgical practice. E-consent forms provide an alternative method for conducting the informed consent (IC) procedure. IC requires an ability to understand, retain, weigh up, and communicate decisions regarding the proposed procedure.

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Basilar artery occlusion management: An international survey of gender influence on management.

Interv Neuroradiol

August 2024

Department of Stroke Medicine, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK.

Background: The superiority of endovascular thrombectomy (EVT) over medical management was not established in two early basilar artery occlusion (BAO) randomized controlled trials. Despite this, many clinicians recommended EVT for acute BAO under certain circumstances. This paper aims to compare physicians' diagnostic and management strategies of BAO according to gender.

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Article Synopsis
  • Endovascular treatment (EVT) is advised for acute ischemic stroke caused by large-vessel occlusion (LVO) in patients with a decent early CT score (ASPECTS ≥ 6), but recent studies examine its effectiveness in patients with more severe strokes (ASPECTS 0-5).
  • A meta-analysis of six randomized controlled trials (involving 1656 patients) found that EVT significantly improves functional independence and the chances of achieving good functional outcomes after 90 days compared to best medical treatment (BMT) alone.
  • Although EVT leads to higher rates of symptomatic intracranial hemorrhage (sICH), the benefits in terms of improved function at three months outweigh the risks, especially for patients with large
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Patient Selection, Outcome, and Unhappy Patients in Rhinoplasty.

Facial Plast Surg

September 2024

Department of Otorhinolaryngology, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland.

This article discusses the process of patient selection for rhinoplasties and the many different psychological aspects that come into play. It is important to identify the warning signs and apply a multidisciplinary approach to the surgeons practice, in collaboration with specialist rhinoplasty psychologists. Patients' motivations and surgeon factors are also discussed, as this can lead to unhappy and unsatisfactory postoperative outcomes.

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Ventriculoperitoneal shunt extrusion in pediatric patients, clinical patterns and therapeutic strategies: A scoping review.

Surg Neurol Int

July 2024

Department of Neurosurgery, Imperial College Healthcare National Health Services Trust, Charing Cross Hospital, London, United Kingdom.

Background: Ventriculoperitoneal shunts (VPSs) are frequently employed in neurosurgery to treat hydrocephalus, with a particular focus on pediatric patients. Although VPSs are commonly utilized, they are not exempt from difficulties, such as shunt extrusion. The main aim of this study is to enhance comprehension regarding the occurrence, causes contributing to, and consequences of VPS extrusion in pediatric patients.

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Pre-operative chemoradiotherapy followed by mastectomy and breast reconstruction-A systematic review of clinical, oncological, reconstructive and aesthetic outcomes.

J Plast Reconstr Aesthet Surg

September 2024

Imperial College Healthcare NHS Trust, Department of Breast Surgery, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom; Department of Surgery and Cancer, Imperial College London, United Kingdom.

Background: Pre-operative radiotherapy (PRT) and pre-operative chemoradiotherapy (PCRT) prior to mastectomy and immediate breast reconstruction for locally advanced breast cancer have the potential to reduce radiation late-effects and expedite oncologic treatment. Recent feasibility work indicates that PCRT is safe and technically possible. Here, we present a systematic review of currently available data on clinical, oncological, reconstructive and aesthetic outcomes.

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Intraoperative frozen section (IFS) is used with the intention to improve functional and oncological outcomes for patients undergoing radical prostatectomy (RP). High resource requirements of IFS techniques such as NeuroSAFE may preclude widespread adoption, even if there are benefits to patients. Recent advances in fresh-tissue microscopic digital imaging technologies may offer an attractive alternative, and there is a growing body of evidence regarding these technologies.

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Introduction: The healthcare sector is a major contributor to the climate crisis and operating theatres (OTs) are one of the highest sources of emissions. To inform emissions reduction, this study aimed to (i) compare the outcomes of interventions targeting sustainable behaviours in OTs using the Triple Bottom Line framework, (ii) categorise the intervention strategies using the five Rs (reduce, recycle, reuse, refuse, and renew) of circular economy, and (iii) examine intervention functions (IFs) using the Behaviour Change Wheel (BCW).

Methods: Medline, Embase, PsychInfo, Scopus, and Web of Science databases were searched until June 2023 using the concepts: sustainability and surgery.

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Challenges with segmenting intraoperative ultrasound for brain tumours.

Acta Neurochir (Wien)

August 2024

Department of Neurosurgery, Charing Cross Hospital, Fulham Palace Rd, W6 8RF, London, UK.

Objective - Addressing the challenges that come with identifying and delineating brain tumours in intraoperative ultrasound. Our goal is to both qualitatively and quantitatively assess the interobserver variation, amongst experienced neuro-oncological intraoperative ultrasound users (neurosurgeons and neuroradiologists), in detecting and segmenting brain tumours on ultrasound. We then propose that, due to the inherent challenges of this task, annotation by localisation of the entire tumour mass with a bounding box could serve as an ancillary solution to segmentation for clinical training, encompassing margin uncertainty and the curation of large datasets.

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Objectives: The clinical activity score (CAS) and European severity scale (ESS) are established clinical tools to assess thyroid eye disease (TED) but are limited in terms of subjectivity and their reliability in non-Caucasian individuals, and can underestimate significant disease in the posterior orbit. Preliminary data from pilot studies have shown that diffusion-weighted imaging (DWI) using extraocular muscle (EOM) apparent diffusion coefficient (ADC) measurements may provide complementary information in TED. This study expands on previous research to assess for correlations between clinical scores and EOM-ADCs in stratifying disease activity and severity in a large patient cohort from an ethnically diverse population.

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Article Synopsis
  • Current estimates of genetic variants linked to Parkinson's disease (PD) show limitations and biases across different populations, complicating patient recruitment for clinical trials focused on genetic therapies.
  • The Rostock Parkinson's disease (ROPAD) study analyzes data from 12,580 PD patients across 16 countries, revealing that 14.8% had a genetic test positive for PD-related variants, particularly in specific genes like GBA1 and LRRK2.
  • Findings indicate higher positivity rates in patients with earlier onset (age ≤ 50) or a positive family history, emphasizing the need for more extensive genetic investigation to improve patient stratification for future clinical trials.
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Article Synopsis
  • Many patients with multiple sclerosis (MS) still show gradual deterioration of symptoms even when on treatment that prevents relapses, indicating the need for more comprehensive understanding beyond traditional views of MS progression.
  • The authors introduce a new term, smouldering-associated-worsening (SAW), which refers to ongoing physical and cognitive decline caused by underlying pathological processes that haven’t been adequately addressed in therapy.
  • They also suggest ways to monitor SAW using clinical, radiological, and biological markers, while emphasizing the importance of integrating findings on smouldering MS into both clinical practice and future research.
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Novel Blood-Based Biomarkers and Disease Modifying Therapies for Alzheimer's Disease. Are We Ready for the New Era?

J Prev Alzheimers Dis

July 2024

Roxanna Korologou-Linden, Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, 11th Floor, Charing Cross Hospital Campus, W6 8RP, Email: Tel: +44 20 3311 0208.

Article Synopsis
  • * Accurate diagnosis relies on tests like cerebrospinal fluid analysis and neuro-imaging to confirm Alzheimer's pathology, but blood-based biomarkers present a promising, less invasive alternative.
  • * Despite the potential of these new diagnostic and therapeutic approaches, healthcare systems may struggle with implementation due to limitations in capacity, finances, and infrastructure.
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Androgens, formerly known as anabolic-androgenic steroids, mimic the effects of testosterone and are being increasingly abused for nonmedical purposes such as body and performance enhancement. Androgen abuse is associated with increased mortality, and multisystem adverse effects have been reported, including cardiovascular toxicity, infertility, hypogonadism, hepatotoxicity, and mental health disorders. Men may present with the negative health consequences of androgen abuse even despite cessation for a number of years.

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