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Charing Cross hospital[Affiliation] Publications | LitMetric

4,357 results match your criteria: "Charing Cross hospital[Affiliation]"

Article Synopsis
  • A study aimed to compare outcomes of general anesthesia (GA) versus non-general anesthesia (non-GA) in patients aged 90 and older undergoing mechanical thrombectomy (MT) for acute ischemic stroke, a group often excluded from previous research.
  • The analysis included 139 patients, with those receiving non-GA showing significantly worse outcomes in 90-day modified Rankin Scale (mRS) scores and higher mortality rates.
  • The findings suggest that nonagenarians treated with MT without GA have poorer prognoses, highlighting the need for further research on anesthesia techniques for this age group.
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Sarcopenia in the foot on magnetic resonance imaging in patients with diabetes mellitus - a systematic review.

Clin Diabetes Endocrinol

October 2024

Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, 4th Floor, North Wing, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom.

Introduction: Sarcopenia is defined by low measures of muscle quantity, quality and reduced physical performance. It is associated with higher levels of frailty. Individuals with diabetes mellitus (DM) undergo sarcopenia at an accelerated rate resulting in structural changes potentially culminating in limb loss.

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The parotid gland is a rare site for distant metastasis. We aim to provide an overview of metastatic tumours to the parotid over the past 20 years, focusing on clinicopathological analysis of 14 rare diagnoses. To the best of our knowledge, we are the first group to present the most up-to-date and largest case series on unusual metastases to the parotid.

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Inflammatory environments induce the generation of dysfunctional IFNγT-betFOXP3 Th1-like Tregs, which show defective function and are found in autoimmune conditions including multiple sclerosis (MS). The pathways that control the generation of Th1-like Tregs are not well understood. Sphingosine-1-phosphate (S1P) signalling molecules are upregulated in Th1-like Tregs, and in vivo S1P inhibition with Fingolimod (FTY720) inhibits the expression of genes responsible for Treg plasticity in MS patients.

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Objective: Recurrent respiratory papillomatosis is a rare disease characterised by growth of papilloma within the respiratory tract. The disease course is variable but can require frequent surgical interventions alongside adjuvant medical treatments. There is no definitive curative treatment or gold-standard guidelines for management.

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Robotic minimally invasive surgery (MIS) has changed numerous surgical techniques in the past few years and enhanced their results. Haptic feedback is integrated into robotic surgical systems to restore the surgeon's perception of forces in response to interaction with objects in the surgical environment. The ideal exact emulation of the robot's interaction with its physical environment in free space is a very challenging problem to solve completely.

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Article Synopsis
  • - The ATTEST-2 trial evaluated if tenecteplase, a newer thrombolytic agent, is at least as effective as the standard alteplase within 4.5 hours of an acute ischaemic stroke by comparing outcomes like the modified Rankin Scale (mRS) at 90 days post-treatment.
  • - Conducted across 39 UK stroke centers, the study randomly assigned 1,777 eligible stroke patients to receive either tenecteplase or alteplase, focusing on their recovery outcomes and safety, including complications such as bleeding.
  • - Results showed that tenecteplase was non-inferior to alteplase regarding the distribution of mRS scores, but it did not
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The Influence of Facial Injury during the First World War on the Development of Plastic and Reconstructive Surgery in Britain and Germany.

Facial Plast Surg

November 2024

Department of Otolaryngology, Charing Cross Hospital, Imperial College of Medicine, Imperial College London, London, United Kingdom.

In the First World War (WW1), different types of injuries became both political and economic factors for the main belligerent countries. This work illustrates the special role facial injuries played during and after the war and the profound impact they had on the field of Plastic Surgery in Britain and Germany.This is a historical work based on primary and secondary sources.

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Penile abscesses of the corpus spongiosum are rare in urology, with few documented cases. These abscesses may occur spontaneously or due to risk factors such as diabetes mellitus, intracavernosal injection therapy, tuberculosis, trauma, and perianal or intra-abdominal abscesses. This report discusses a 76-year-old man who developed a penile abscess involving the corpus spongiosum following intermittent self-dilatation.

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Background: Emerging evidence indicates a frequent occurrence of atrial fibrillation (AF) detection among patients with established causes of ischemic stroke unrelated to AF. This systematic review and meta-analysis aimed to evaluate AF detection rates in stroke patients with large or small vessel disease, considering the AF detection modality and duration of cardiac rhythm monitoring.

Aims: We conducted a comprehensive search of PubMed and Scopus databases up to 2 March 2024, to identify randomized controlled trials, non-randomized prospective studies, and retrospective studies assessing the frequency of AF detection in stroke patients with large or small vessel disease.

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Frontoparietal atrophy trajectories in cognitively unimpaired elderly individuals using longitudinal Bayesian clustering.

Comput Biol Med

November 2024

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Neo 7th floor, SE-141 83, Huddinge, Sweden; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience: King's College London, De Crespigny Park, London, SE5 8AF, UK. Electronic address:

Introduction: Frontal and/or parietal atrophy has been reported during aging. To disentangle the heterogeneity previously observed, this study aimed to uncover different clusters of grey matter profiles and trajectories within cognitively unimpaired individuals.

Methods: Structural magnetic resonance imaging (MRI) data of 307 Aβ-negative cognitively unimpaired individuals were modelled between ages 60-85 from three cohorts worldwide.

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Visual mismatch negativity in Parkinson's psychosis and potential for testing treatment mechanisms.

Brain Commun

September 2024

Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

Article Synopsis
  • * The study investigates the mismatch negativity (a brain response to sensory changes) in individuals with and without visual hallucinations to determine its potential as a psychosis marker in Parkinson's.
  • * Results show that those with visual hallucinations exhibit reduced mismatch negativity compared to those without, suggesting that greater hallucination severity correlates with lower amplitude of this brain response, potentially linking serotonergic mechanisms to hallucinations.
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Background And Objective: Bacteriuria is anticipated in long-term indwelling catheter (IDC) use, and urinary tract infections (UTIs) and related issues are common. Defence mechanisms against infection are undermined by the presence of a Foley catheter, and adjustments to design could influence UTI risk.

Methods: We reviewed the various aspects of IDCs and ureteric stent designs to discuss potential impact on UTI risk.

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Changes in Phenotypic and Molecular Features of Naïve and Central Memory T Helper Cell Subsets following SARS-CoV-2 Vaccination.

Vaccines (Basel)

September 2024

Centre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.

Molecular changes in lymphocytes following SARS-CoV-2 vaccination are incompletely understood. We hypothesized that studying the molecular (transcriptomic, epigenetic, and T cell receptor (TCR) repertoire) changes in CD4 T cells following SARS-CoV-2 vaccination could inform protective mechanisms and refinement of future vaccines. We tested this hypothesis by reporting alterations in CD4 T cell subsets and molecular features of CD4 naïve and CD4 central memory (CM) subsets between the unvaccinated and vaccinated groups.

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Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.

Clin Microbiol Infect

December 2024

OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:

Article Synopsis
  • Hospital-acquired bloodstream infections (HA-BSI) in ICU patients can be life-threatening, and this study aimed to see how early adequate antibiotic treatment affects 28-day mortality rates for patients who survive at least one day after infection onset.
  • Using data from a multicenter study with 2,418 patients, researchers found that those who received adequate treatment within 24 hours had a lower 28-day mortality rate (32.8%) compared to those who were inadequately treated (40%).
  • The study concluded that inadequate antibiotic therapy within 24 hours contributes significantly to 28-day mortality, indicating that quicker treatment could greatly improve patient outcomes in cases of HA-BSI.
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Future Directions for Gestational Trophoblastic Disease.

Hematol Oncol Clin North Am

December 2024

Department of Medical Oncology, Gestational Trophoblastic Disease Centre, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK. Electronic address:

Gestational trophoblastic disease encompasses a spectrum of premalignant and malignant conditions. While centralized care models significantly improve survival rates, many countries still lack such specialized centers, leading to preventable deaths. Current research focuses on refining diagnostic and treatment methods, aiming to better predict the risk of malignancy and reduce the need for aggressive therapies.

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Antimicrobial resistance: a concise update.

Lancet Microbe

January 2025

Ocular Infections and Anti-Microbials Research Group, Singapore Eye Research Institute, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore; Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Birmingham and Midland Eye Centre, Sandwell and West Birmingham NHS Trust, Birmingham, UK; Academic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, UK. Electronic address:

Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive approach that ranges from increased understanding of mechanisms and drivers at the individual and population levels, AMR surveillance, antimicrobial stewardship, improved infection prevention and control measures, and strengthened global policies and funding to development of novel antimicrobial therapeutic strategies. In this rapidly advancing field, this Review provides a concise update on AMR, encompassing epidemiology, evolution, underlying mechanisms (primarily those related to last-line or newer generation of antibiotics), infection prevention and control measures, access to antibiotics, antimicrobial stewardship, AMR surveillance, and emerging non-antibiotic therapeutic approaches.

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Sarcoidosis is an inflammatory, non-caseating granulomatous multisystem disease associated with JAK-STAT (Janus kinases-signal transducer and activator of transcription proteins) pathway activation. We present a patient with severe multi-systemic sarcoidosis who showed marked improvement with tofacitinib with regards to pulmonary, cutaneous, nasal and laryngeal disease. Tofacitinib prevented critical laryngeal stenosis from progressing to tracheostomy, induced regression of cutaneous lesions and improved pulmonary function in this steroid-resistant and immunosuppressive intolerant case.

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Importance: While the typical onset of multiple sclerosis (MS) occurs in early adulthood, 2% to 10% of cases initially present prior to age 18 years, and approximately 5% after age 50 years. Guidance on approaches to differential diagnosis in suspected MS specific to these 2 age groups is needed.

Observations: There are unique biological factors in children younger than 18 years and in adults older than age 50 years compared to typical adult-onset MS.

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