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Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors.
PLoS One
December 2015
CNRS UMR8147, Paris Descartes University, Paris, France; Laboratory of Oncohematology, AP-HP, Necker Children's Hospital, INSERM U1151, Paris, France; INSERM U1163, CNRS ERL 8254, Laboratory of cellular and molecular basis of hematological disorders and their therapeutic implications, Imagine Institute, Paris, France.
Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments.
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