Potential Role and Prognostic Value of Interleukin-15 for Mortality Among Elderly Patients with Sepsis.

Background: To investigate the potential role and prognostic value of interleukin-15 (IL-15) in predicting 28-day mortality in elderly patients with sepsis.

Methods: According to the Sepsis-3.0 diagnostic criteria for sepsis, elderly patients with sepsis who were admitted to the emergency department of the Shi jingshan branch of Beijing Chaoyang Hospital between October 2021 and June 2022 were enrolled in this retrospective cohort study.

Sex Differences in Intracranial Atherosclerosis in Patients With Hypertension With Acute Ischemic Stroke.

Background Studies suggest the presence of sex differences in hypertension prevalence and its associated outcomes in atherosclerosis and stroke. We hypothesized a higher intracranial atherosclerosis burden among men with hypertension and acute ischemic stroke compared with women. Methods and Results A multicenter retrospective study was performed from a prospective database identifying patients with hypertension presenting with intracranial atherosclerosis-related acute ischemic stroke and imaged with intracranial vessel wall magnetic resonance imaging.

MiR-212-3p suppresses high-grade serous ovarian cancer progression by directly targeting MAP3K3.

MicroRNAs (miRNAs) are small regulatory non-coding RNAs that have been reported to play an important role in the tumorigenesis of many cancers. In addition, miRNAs might serve as new promising biomarkers for diagnosis and prognosis and as effective therapeutic targets for patients with such malignancies. Accordingly, the dysregulation of miR-212-3p has been reported in a variety of human cancers.

Correlation of macrophage inflammatory protein-1α single gene polymorphisms with the susceptibility to pigeon breeder's lung in chinese uygur population.

Objective: To investigate the correlation of macrophage inflammatory protein-1α (MIP-1α) gene single nucleotide polymorphisms (SNP) with the susceptibility to pigeon breeder's lung (PBL) in Chinese Uygur population.

Methods: A total of 92 Uygur from Xinjiang, China were enrolled in the study. Among them, there were 32 patients with PBL, 30 negative controls with history of exposure to pigeons and 30 normal controls without pigeons contact.

[Lung cancer with marked blood eosinophilia: case report and literature review].

Objective: To study the clinical characteristics and significance of blood eosinophilia in lung cancer.

Methods: A case of lung cancer with eosinophilia in the peripheral blood was analyzed, and the related literature was reviewed.

Results: A 80-year-old male patient presented with chest pain was admitted to this hospital.

[Effects of bone marrow mesenchymal stem cells on bleomycin induced pulmonary fibrosis in rats].

Objective: To study the effects of bone marrow mesenchymal stem cells (MSC) on pulmonary fibrosis.

Methods: Bone marrow MSC were harvested from 6 week old male SD rats. Forty-eight female SD rats were randomly divided into six groups.

[The changes of serum enzymes and cardiac troponin I in patients with acute pulmonary thromboembolism].

Objectives: To investigate the changes of serum enzymes and cardiac troponin I (TnI) in patients with acute pulmonary thromboembolism (PTE). The relationships between these changes and the pulmonary artery pressure, the right ventricular function and the prognosis were evaluated.

Methods: This prospective multi-centre trial included 519 patients with confirmed PTE from 24 collaborating hospitals, with 54 cases of massive PTE, 195 sub-massive PTE and 270 non-massive PTE.

[The application of flexirigid thoracoscopy in the diagnosis of pleural effusions with unknown aetiology].

Objective: To investigate the application of Flexirigid thoracoscopy in the diagnosis of pleural effusions with unknown aetiology.

Methods: Sixty patients (male 36, female 24) with pleural effusions of unknown aetiology, were examined with Flexirigid thoracoscopy from July 2005 to March 2007 in our hospital. Routine examinations of the pleural effusions, including biochemistry and cytology, as well as sputum cytology and bronchoscopy had failed to reach a definite diagnosis.

[Risk factors and clinical features of deep venous thrombosis: a report of 388 cases].

Objective: To investigate the risk factors and clinical characteristics of deep venous thrombosis (DVT) and pulmonary thromboembolism (PTE).

Method: The clinical manifestations and risk factors in 388 patients with DVT were retrospectively studied.

Results: The ratio of DVT cases in hospitalized patients had a trend of increasing in recent years.

[Study of the function of coagulation, fibrinolysis and pulmonary vascular endothelium before and after experimental pulmonary thromboembolism in rabbits].

Objectives: To study the functional changes and the significance of coagulation, fibrinolysis and pulmonary vascular endothelium before and after experimental pulmonary thromboembolism in rabbits.

Methods: Rabbit pulmonary thromboembolism models by injection of auto-blood clots into femoral vein were used to observe the dynamical changes of activity of coagulation and fibrinolysis and endothelin-1 (ET-1), nitrogen monoxide (NO), von Willebrand factor (vWF) in blood.

Results: Petechial and patchy hemorrhages were observed on the surfaces of embolic lungs.

[The relationship between the peripheral blood of CD61, CD63, PAC-1 and the transplant kidney function].

Objectives: To explore the relationships between the peripheral blood levels of CD61, CD63, PAC-1 and the incidence of acute rejection and tubular necrosis after renal transplantation, and recovery of the graft function.

Methods: The peripheral blood levels of CD61, CD63, and PAC-1 of 86 patients with uremia in different stages before and after transplantations were analyzed by flow cytometry. The patients were divided into three groups: (1) twenty-nine patients with normal grafts function, (2) hirty with acute rejection and (3) twenty-seven with acute tubular necrosis.

[Comparison of thrombolysis and anticoagulation in pulmonary thromboembolism: a meta-analysis].

Objective: To pool the data of studies about thrombolysis in pulmonary thromboembolism (PTE) and evaluate the efficacy and safety of thrombolysis.

Methods: The randomized clinical trials (RCTs) that compared the efficacy or safety of thrombolysis and anticoagulation in massive or submassive PTE were chosen from MEDLINE disks from 1966 to May of 2003 and CBM disks from 1978 to May of 2003. A meta-analysis was employed to evaluate the results of the two therapies.

[Association between polymorphisms in the gene coding for glutathione S-transferase P1 and chronic obstructive pulmonary disease].

Objective: To investigate the association between polymorphisms in the gene coding for glutathione S-transferase P1 (GSTP1) and susceptibility to chronic obstructive pulmonary disease (COPD) in a Chinese population.

Methods: This was a pilot study of the molecular epidemiology in patients with COPD. The research design was a case-control study.

[Inhibition of cytokine release from alveolar macrophages in pulmonary sarcoidosis by pentoxifylline].

Objective: Pentoxifylline (POF) has recently been shown to suppress the cytokine production from lipopolysaccharide (LPS) stimulated monocytes/alveolar macrophages (AM). Sarcoidosis is a granulomatous disease which is driven by the action of tumor necrosis factor (TNF-alpha) and other proinflammatory cytokines. It was investigated that the effects of POF on the production of TNF-alpha, interleukin (IL)-1beta, IL-6, IL-8, IL-10 and the soluble TNF-alpha receptors (sTNFR-1 and sTNFR-2) from AM in sarcoidosis, as comparison to dexamethasone (DEX).

[The pathology of and the cardio-pulmonary functional changes in acute multiple pulmonary microthromboembolism in a canine model].

Objective: To evaluate the effect of acute multiple pulmonary microthromboembolism on circulation, ventilation, lung histology, and the coagulatory and fibrinolytic functions.

Methods: Thirteen dogs were studied, 7 in the embolism group and 6 in the control group. 10 ml of blood was withdrawn from each animal.

[Prophylactic effect of retinoic acid on chronic obstructive pulmonary emphysema in rats].

Objective: To evaluate the effect and molecular mechanism of retinoic acid (RA) in preventing experimental pulmonary emphysema in rats.

Methods: Thirty-six Wistar rats were randomly divided into three groups, the normal group(A), the model group (B) and the RA treated group (C). Rats in group B group were exposed to cigarette smoke, and group C was treated with RA.

Effects of extrinsic positive end-expiratory pressure on cardiopulmonary function in patients with chronic obstructive pulmonary disease.

Objective: To choose one optimal extrinsic positive end-expiratory pressure (PEEPe) for ventilated patients with chronic obstructive pulmonary disease (COPD) and to compare two methods for choosing the optimal level of PEEPe.

Methods: Ten ventilated patients with COPD were included in the study. First, static intrinsic positive end-expiratory pressure (PEEPi, st) was measured when PEEPe was zero, and the PEEPi, st was called PEEPi, stz.

Effects of extrinsic positive end-expiratory pressure on work of breathing in patients with chronic obstructive pulmonary disease.

Objective: To investigate the effects of extrinsic positive end-expiratory pressure (PEEPe) on work of breathing in patients with chronic obstructive pulmonary disease (COPD) and their corresponding mechanism.

Methods: Ten ventilated patients with COPD were included in the study. A Bicore CP-100 pulmonary monitor (Bicore Monitoring System, USA) was used for monitoring respiratory mechanics.

[Proportional assist ventilation: methodology therapeutics on COPD patients compared with pressure support ventilation].

Objective: To establish the method for clinical use of proportional assist ventilation (PAV) and evaluate the effect on COPD patients. The main similarities and differences of PAV and pressure support ventilation (PSV) were described.

Methods: 10 ventilated patients of COPD were studied.

[Sequential non-invasive following short-term invasive mechanical ventilation in COPD induced hypercapnic respiratory failure].

Objective: To estimate the feasibility and the efficacy of early extubation and sequential non-invasive mechanical ventilation(MV) in COPD with exacerbated hypercapnic respiratory failure.

Methods: 22 intubated COPD cases with severe hypercapnic respiratory failure due to pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. At the time pulmonary infection had been significantly controlled (resolution of fever and decrease in purulent sputum, radiographic infiltrations, and leukocytosis.

[Changes in respiratory and circulatory function during sequential invasive-noninvasive mechanical ventilation].

Objective: To investigate the change of respiratory and circulatory function in COPD during sequential invasive-noninvasive mechanical ventilation.

Methods: 12 COPD patients with type II respiratory failure were ventilated via endotracheal intubation. When pulmonary infection was under control (the appearance of "PIC Window"), all patients were extubated and received mask ventilation.