Exploring antibiofilm potential of some new imidazole analogs against synthesis, antifungal activity, molecular docking and molecular dynamics studies.

A series of 1, 2, 4, 5-tetrasubstituted imidazole derivatives were synthesized and their antibiofilm potential against was evaluated . Two of the synthesized derivatives IC= 25 µg/mL) and (IC= 6 µg/mL),displayed better antifungal and antibiofilm potential than the standard drug Fluconazole (IC = 40 µg/mL) against . Based on the results, we escalated the real time polymerase chain reaction (RT-PCR) analysis to gain knowledge of the enzymes expressed in the generation and maintenance of biofilms and the mechanism of biofilm inhibition by the synthesized analogues.

analysis of polyphenols and flavonoids for design of human Nav1.7 inhibitors.

Neuropathic pain is commonly associated with lesion or disease of the somatosensory system and often reflected as indicator of impaired life. Although the central nervous system is main regulator of pain but for initiation and maintenance of the neuropathic pain is regulated by peripheral nervous system. Sodium channels particularly Nav1.

Insilico analysis of marine indole alkaloids for design of adenosine A2A receptor antagonist.

Neurological disease is the disease associated with most of geriatric population in the world. The diseases like Alzheimer's disease and Parkinson's disease are associated with the change in the life style in current era. Treatment of these diseases normally focused on the agents which can able to manipulate the neurotransmitter release, so it is associated with severe side effects.