53 results match your criteria: "Changzhou Wujin People's Hospital[Affiliation]"
Stem cell factor (SCF) protects osteoblasts from oxidative stress through activating c-Kit-Akt signaling.
Biochem Biophys Res Commun
December 2014
Department of Orthopedics, Changzhou Wujin People's Hospital-South Division, Affiliated Hospital of Jiangsu University, Changzhou, China. Electronic address:
Osteoblasts regulate bone formation and remodeling, and are main target cells of oxidative stress in the progression of osteonecrosis. The stem cell factor (SCF)-c-Kit pathway plays important roles in the proliferation, differentiation and survival in a range of cell types, but little is known about its functions in osteoblasts. In this study, we found that c-Kit is functionally expressed in both osteoblastic-like MC3T3-E1 cells and primary murine osteoblasts.
View Article and Find Full Text PDFCritical illness-related corticosteroid insufficiency after multiple traumas: a multicenter, prospective cohort study.
J Trauma Acute Care Surg
June 2014
From the Department of Critical Care Medicine (Y.Y., L.L., D.J., H.Q.), Nanjing Zhongda Hospital and School of Medicine, Southeast University; and Department of Critical Care Medicine (Z.Y.), Nanjing Jiangbei People's Hospital, Nanjing; Department of Critical Care Medicine (J.W.), Jintan People's Hospital, Jintan; Department of Critical Care Medicine (J.Y.), Jiangsu Taizhou People's Hospital, Taizhou; Department of Critical Care Medicine (J.C.), Changzhou Wujin People's Hospital, Changzhou; Department of Critical Care Medicine (M.Z.), Nanjing Gaochun People's Hospital, Gaochun; Department of Critical Care Medicine (D.A.), Lishui District, Nanjing City, People's Hospital.
Background: Given that the observed prevalence and time course of critical illness-related corticosteroid insufficiency (CIRCI) remain inconsistent in trauma patients, the present study was designed to investigate the prevalence, time course, and effect of CIRCI on the outcome of critically ill patients with multiple injuries.
Methods: In this multicenter, prospective cohort study, patients with multiple injuries in seven intensive care units in China were enrolled. Adrenocorticotropic hormone (ACTH) stimulation tests were performed by administering intravenously 250 μg of synthetic ACTH on Days 1, 2, 3, 5, and 7 after traumatic injury.
Estrogen suppresses adipogenesis by inhibiting S100A16 expression.
J Mol Endocrinol
June 2014
Department of Geratology Laboratory Animal Center, The First Affiliated Hospital The Center of Metabolism, Nanjing Medical University, Nanjing 210029, China Department of Urology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210008, China Department of Orthopedics, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing, Jiangsu, China Department of Endocrinology, Changzhou Wujin People's Hospital, 213000 Changzhou, Jiangsu, China.
The aim of this study is to determine the effects of E2 on metabolic syndrome and the molecular mechanisms involving S100A16. Ovariectomized (OVX) rat models and mouse embryonic fibroblasts cell models were used. E2 loss in OVX rats induced body weight gain and central abdominal fat accumulation, which were ameliorated by E2 treatment under chow and high-fat diet (HFD) conditions.
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