Pd/MIL-100(Fe) as hydrogen activator for Fe/Fe cycle: Fenton removal of sulfamethazine.

Masses of iron sludge generated from engineering practice of classic Fenton reaction constraints its further promotion. Accelerating the Fe/Fe cycle may be conducive to reducing the initial ferrous slat dosage and the final iron sludge. Based on the reduction of Pd/MIL-100(Fe)-activated hydrogen, an improved Fenton system named MHACF-MIL-100(Fe) was developed at ambient temperature and pressure.

Position of Biphenyl Group Turning the Structure and Photophysical Property of D-π- π -A Prototype Fluorescent Material.

Three novel D-π-π-A prototype compounds, namely, (E)-2-(3-([1,1'-biphenyl]-2-yl)-1-(9H-fluoren-2-yl)allylidene)malononitri-le (2-BAM), (E)-2-(3-([1,1'-biphenyl]-3-yl)-1-(9H-fluoren-2-yl)allylidene)malononitri-le (3-BAM), and (E)-2-(3-([1,1'-biphenyl]-4-yl)-1-(9H-fluoren-2-yl)allylidene)malononitri-le (4-BAM) were synthesized. Furthermore, the structures and photophysical properties of three compounds were compared. Molecules of 2-BAM were packed into a 1D column structure with H-aggregation.

Investigation of the Solid-Solution Limit, Crystal Structure, and Thermal Quenching Mitigation of Sr-Substituted RbCaPO:Eu Phosphors for White LED Applications.

RbCaPO:Eu is a bright reddish-orange-emitting phosphor, but its luminescence thermal stability is poor. In this study, we investigated the solid-solution limit and thermal quenching mitigation of RbCaPO:Eu phosphors by cation substitution with Sr and revisited their crystal structure. First, we carefully investigated the solid solution limit of Sr in the structure of RbCaPO.

HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction.

Aims: Naturally secreted extracellular vesicles (EVs) play important roles in stem-mediated cardioprotection. This study aimed to investigate the cardioprotective function and underlying mechanisms of EVs derived from HIF-1α engineered mesenchymal stem cells (MSCs) in a rat model of AMI.

Methods And Results: EVs isolated from HIF-1α engineered MSCs (HIF-1α-EVs) and control MSCs (NC-EVs) were prepared.

Theoretical study of myriocin-binding mechanism targeting serine palmitoyltransferase.

Sphingolipids (SLs) are vital for cells as forming membrane and transducing signals. The first step for de novo biosynthesis of SLs is catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT), which has been proven to be a promising drug target for treating various diseases. However, there are few SPT-specific inhibitors have been identified so far.

Ultrasensitive Electrochemical Impedance Chiral Discrimination and Sensing of Tryptophan Isomers Based on Core-Shell-Structured Au-Ag Nanoparticles.

Au-Ag nanoparticles (Au-Ag NPs) with a core-shell structure are prepared and used for ultrasensitive electrochemical impedance (EI) discrimination of the isomers of tryptophan (Trp). As revealed by circular dichroism, rotary polarization caused by the Au-Ag NPs is consistent with D-Trp but opposite to L-Trp, and thus, the Au-Ag NPs can selectively combine with D-Trp through preferential interactions. Compared with Au-Ag NPs, the composites of D-Trp and Au-Ag NPs (Au-Ag NPs/D-Trp) display significantly increased charge transfer resistance (); differently, the of Au-Ag NPs/L-Trp remains almost unchanged because the Au-Ag NPs exhibit poor affinity toward L-Trp.

A novel colorimetric and ratiometric fluorescence probe based on 'C-CN' for detection of hydrazine and its imaging in living cells and mouse.

Hydrazine plays an important role in chemistry, pharmaceuticals, agriculture and aerospace. However, it is not to be underestimated and has been identified as harmful to the human body. Therefore, it is significant and urgent to develop the detection of hydrazine in vivo and in vitro.

Controlling the microbial composition during the fermentation of Ishizuchi-kurocha.

Ishizuchi-kurocha is a popular postfermented tea in Japan. It is performed by domestic and natural fermentation relied on microorganisms derived from tea leaves or the environment of the manufacturing. Ishizuchi-kurocha undergoes aerobic fermentation of fungi first, then second fermented by anaerobic fermentation of lactic acid bacteria during natural fermentation processing.

Electrochemical Oxidative C(sp)-H/N-H Coupling of Diarylmethanes with Sulfoximines or Benzophenone Imine.

Herein, we report an efficient electrochemical method for the synthesis of -alkylated sulfoximines by electrochemical oxidative C(sp)-H/N-H coupling of sulfoximines and diarylmethanes. In addition, we used the same conditions for electrochemical dehydrogenative amination of diarylmethanes with benzophenone imine as an aminating agent. The reactions showed good functional group tolerance and afforded the corresponding products in moderate to good yields without the use of a stoichiometric oxidant, a metal catalyst, or an activating agent.

[Effects of peak compression in gradient elution of liquid chromatography].

Peak compression is a unique feature of gradient elution and is non-existent in isocratic elution. Since the classical plate height equation, which is also called as van Deemter equation, is derived by assuming isocratic elution, it cannot be used to account for the effects of peak compression. As opposed to the case of isocratic elution, the retention factor () varies with the mobile phase composition () under gradient elution, thereby complicating mathematical analysis.

Applying EEM- PARAFAC Analysis With Quantitative Real-Time PCR to Monitor Methanogenic Activity of High-Solid Anaerobic Digestion of Rice Straw.

The methanogenic activity is an important indicator to assess the efficiency of high-solid anaerobic digestion. However, it is not yet elucidated clearly how to detect the parameter rapidly and reliably in the rice straw feeding reactor. Co-inoculated with ruminal digesta and anaerobic sludge, the digestion performance was studied at three different organic loading rates (OLRs).

Enantioselective recognition of tryptophan isomers with molecularly imprinted overoxidized polypyrrole/poly(p-aminobenzene sulfonic acid) modified electrode.

Poly(p-aminobenzene sulfonic acid) (pABSA) was electrodeposited onto the surface of a glassy carbon electrode (GCE), which was then used for the preconcentration of l-tryptophan (l-Trp) due to the electrostatic and π-π interactions between pABSA and l-Trp. Polypyrrole (PPy) was electrodeposited onto the surface of the l-Trp enriched pABSA, and then the l-Trp templates were removed, resulting in molecularly imprinted PPy/pABSA. To avoid the interference from the oxidation peak of PPy on the following electrochemical chiral recognition of Trp isomers, PPy was overoxidized by cyclic voltammetry (CV).

A colorimetric indicator-displacement assay based on stable Cu selective carbon dots for fluorescence turn-on detection of pyrophosphate anions in urine.

Determination of PPi levels in urine represents a measurable factor for diagnostic, treatment, and monitoring of urolithiasis. Owing to the quenching ability of Cu on fluorescent carbon dots (CDs) and strong binding affinity between Cu and PPi, we develop a new off-on assay for PPi detection using newly BPHA CDs (BPHA: N,N-bis(pyridin-2-ylmethyl)hexan-1-amine). The fluorescence intensity of BPHA CDs was significantly quenched by Cu ("off") through forming BPHA CDs/Cu complexes and the fluorescence intensity of BPHA CDs /Cu system was completely resumed by PPi ("on") owing to the release of free Cu.

Targeting phosphatidylinositol 3-kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors.

Phosphatidylinositol 3-kinase gamma (PI3Kγ) has been regarded as a promising drug target for the treatment of advanced solid tumors, leukemia, lymphoma, and inflammatory and autoimmune diseases. However, the high level of structural conservation among the members of the PI3K family and the diverse physiological roles of Class I PI3K isoforms (α, β, δ, and γ) highlight the importance of isoform selectivity in the development of PI3Kγ inhibitors. In this review, we provide an overview of the structural features of PI3Kγ that influence γ-isoform selectivity and discuss the structure-selectivity-activity relationship of existing clinical PI3Kγ inhibitors.

Computer aided optimization of multilinear gradient elution in liquid chromatography.

Analytical expressions for retention time and peak compression factor are deduced by assuming quadratic solvent strength model and multilinear gradient elution. Based on these expressions, a program for the optimization of multilinear gradient profile is written with Visual Basic for Applications in Excel using genetic algorithm. The program is applied to search for a gradient profile for the separation of twelve compounds that are degraded from lignin.

Templated-Construction of Hollow MoS Architectures with Improved Photoresponses.

Despite the outstanding optoelectronic properties of MoS and its analogues, synthesis of such materials with desired features including fewer layers, arbitrary hollow structures, and particularly specifically customized morphologies, via inorganic reactions has always been challenging. Herein, using predesigned lanthanide-doped upconversion luminescent materials (e.g.

Gender-Specific Association between Serum Uric Acid and Incident Fundus Arteriosclerosis in Chinese Population: A Retrospective Cross-Sectional Study.

Elevated levels of serum uric acid (SUA) were considered to be risk factors for cardiovascular disease, it has been found to be associated with increased arteriosclerosis. The aim of this study was to explore the gender specific relationship between SUA and fundus arteriosclerosis in a healthy population. In a retrospective cross-sectional study, 23474 individuals without diabetes and hypertension were included in the present study.

Mouthpart homologies and life habits of Mesozoic long-proboscid scorpionflies.

Mesozoic long-proboscid scorpionflies (Mesopsychoidea) provide important clues to ancient plant-pollinator interactions. Among them, the family Aneuretopsychidae is especially important because its mouthparts are vital to deciphering the early evolution of Mesopsychoidea and putatively the origin of fleas (Siphonaptera). However, the identification of mouthpart homologs among Aneuretopsychidae remains controversial because of the lack of three-dimensional anatomical data.

Peak compression in linear gradient elution liquid chromatography.

An expression for peak compression factor based on temporal peak widths is proposed which can be measured directly. The relationship between it and peak compression factor based on spatial peak widths is given. The experimental data presented in the Neue's work are reevaluated.

Influence of the pre-elution of solute in initial mobile phase on retention time and peak compression under linear gradient elution.

Under gradient elution the solute will firstly migrate in initial mobile phase due to dwelling time (t) of the system. The pre-elution of solute in initial mobile phase can be accounted for by a dimensionless value of t/(tk), where t and k denote dead time and retention factor in initial mobile phase, respectively. The influence of t/(tk) on retention time (t) and peak compression factor (G) are discussed under linear gradient elution.

Tuning Ni-Foam into NiOOH/FeOOH Heterostructures toward Superior Water Oxidation Catalyst via Three-Step Strategy.

Splitting of water into hydrogen and oxygen has become a strategic research topic. In the two semi-reactions of water splitting, water oxidation is preferred to the four-electron-transfer process with a higher overpotential (η) and is the decisive step in water splitting. Therefore, efficient water oxidation catalysts must be developed.

A Solid-state Electrochemiluminescence Sensor for Detecting Glutathione with a Graphite-phase Carbon Nitride/Silica Modified Glassy Carbon Electrode.

A solid-state electrochemiluminescence (ECL) sensor for the detection of reduced glutathione (GSH) based on a g-CN/SiO modified glass carbon electrode (GCE) has been developed in this research. The g-CN, which is employed as a luminophore, is simply prepared and exhibits an excellent ECL response. Mesoporous silica hollow spheres (SiO) with a large specific surface area are introduced here to increase the loading amount of g-CN.

Responses of Active Ammonia Oxidizers and Nitrification Activity in Eutrophic Lake Sediments to Nitrogen and Temperature.

Ammonium concentrations and temperature drive the activities of ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB), but their effects on these microbes in eutrophic freshwater sediments are unclear. In this study, surface sediments collected from areas of Taihu Lake (China) with different degrees of eutrophication were incubated under three levels of nitrogen input and temperature, and the autotrophic growth of ammonia oxidizers was assessed using C-labeled DNA-based stable-isotope probing (SIP), while communities were characterized using MiSeq sequencing and phylogenetic analysis of 16S rRNA genes. Nitrification rates in sediment microcosms were positively correlated with nitrogen inputs, but there was no marked association with temperature.

Derivative chiral copper(Ⅱ) complexes as template of an electrochemical molecular imprinting sol-gel sensor for enantiorecognition of aspartic acid.

In this work, we reported a novel electrochemical sensor for enantiorecognition of electrochemically inactive aspartic acid (Asp) enantiomers. By combining sol-gel processing with molecular imprinting technology, an enantioselective interface of molecularly imprinted sol-gel (MIS) films with imprinted cavities was prepared on the surface of a glassy carbon electrode (GCE). In order to obtain the electrochemical responses of electrochemically inactive Asp, the ternary derivative of -aspartic, (-aspartic acid)Cu(N-carbobenzoxy--aspartic acid), was used as the template for fabrication of MIS.

Electrochemiluminescence Quenching Sensor of a Carboxylic Carbon Nanotubes Modified Glassy Carbon Electrode for Detecting Crystal Violet Based on Nitrogen-doped Graphene Quantum Dots@Peroxydisulfate System.

In this work, the electrochemiluminscence system of nitrogen-doped graphene quantum dots (N-GQDs) and KSO was built for the determination of crystal violet (CV). Meanwhile, a carboxylic carbon nanotubes modified glassy carbon electrode (CCNTs/GCE) was used as an ECL sensor. Thanks to the excellent electron transfer ability and large surface area of CCNTs, the ECL signal of N-GQDs@SO was remarkablely amplified.