Mechanism of microbial action of the inoculated nitrogen-fixing bacterium for growth promotion and yield enhancement in rice (Oryza sativa L.).

The use of nitrogen-fixing bacteria in agriculture is increasingly recognized as a sustainable method to boost crop yields, reduce chemical fertilizer use, and improve soil health. However, the microbial mechanisms by which inoculation with nitrogen-fixing bacteria enhance rice production remain unclear. In this study, rice seedlings were inoculated with the nitrogen-fixing bacterium R3 (Herbaspirillum) at the rhizosphere during the seedling stage in a pot experiment using paddy soil.

Impacts of ammoniacal odour removal bioagent on air bacterial community.

While biotechnologies offer eco-friendly solutions for eliminating air contaminants, there is a scarcity of research examining the impacts of microbial purification of air pollutants on the structure and function of air microbial communities. In this study, we explored a Lactobacillus paracasei B1 (LAB) agent for removing ammoniacal odour. The impacts of LAB on air bacterial community were revealed.

Abietane diterpenoids from and their cytotoxic activities.

Two new abietane diterpenoids ( and ) and two known analogs ( and ) were isolated from the whole plants of . Their structures were determined by comprehensive spectroscopic methods (UV, IR, NMR, and HRESIMS). Moreover, all compounds were evaluated for their cytotoxic activities against U251 glioblastoma cells.

Developing a ceRNA-based lncRNA-miRNA-mRNA regulatory network to uncover roles in skeletal muscle development.

The precise role of lncRNAs in skeletal muscle development and atrophy remain elusive. We conducted a bioinformatic analysis of 26 GEO datasets from mouse studies, encompassing embryonic development, postnatal growth, regeneration, cell proliferation, and differentiation, using R and relevant packages (limma et al.).

Prevalence of chronic kidney disease among Chinese adults with diabetes: a nationwide population-based cross-sectional study.

Background: To date, comprehensive data on the distribution of chronic kidney disease (CKD), the most prevalent comorbidity in diabetes, among Chinese adults with diabetes is lacking. Additionally, research gaps exist in understanding the association between CKD and cardiovascular health (CVH), an integrated indicator of lifestyle and metabolic control, within a nationwide sample of Chinese adults with diabetes.

Methods: A nationally community-based cross-sectional survey was conducted in 2018-2020.

Analysis of study Global Burden of Disease in 2021: global, regional, and national burden of nutritional deficiency from 1990 to 2021.

Background: Nutrient deficiency disorders (NDs) harm growth, causing economic losses. Addressing NDs is a global priority, yet recent data is limited. This study examines latest NDs data across 204 countries and 21 regions from 1990 to 2021.

Superiority of native seed core microbiomes in the suppression of bacterial wilt disease.

Introduction: Native endophytic microorganisms in tobacco seeds are closely related to their resistance to () infections. However, the role of the native seed core microbiome in the suppression of bacterial wilt disease (BWD) remains underexplored.

Methods: The characteristics of endophytic bacterial communities in both resistant and susceptible tobacco varieties were characterized using high-throughput sequencing technology.

Discovery of Novel Na1.7-Selective Inhibitors with the 1-Indole-3-Propionamide Scaffold for Effective Pain Relief.

Na1.7 is considered a promising target for developing next-generation analgesic drugs, given its critical role in human pain pathologies. Although most reported inhibitors with strong in vitro activity and high selectivity share the aryl sulfonamide scaffold, they failed to demonstrate marked clinical efficacy.

Effects of virtual reality motor games on motor skills in children with cerebral palsy: a systematic review and meta-analysis.

Background: Enhancing motor skills is crucial for the functional development of children with cerebral palsy. Virtual reality has emerged as a promising technology for rehabilitating these children.

Objective: The objective of this study was to systematically evaluate the effects of virtual reality motor games on the gross and fine motor skills of children with cerebral palsy.

N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential.

N7-methylguanosine (m7G) is an important RNA modification involved in epigenetic regulation that is commonly observed in both prokaryotic and eukaryotic organisms. Their influence on the synthesis and processing of messenger RNA, ribosomal RNA, and transfer RNA allows m7G modifications to affect diverse cellular, physiological, and pathological processes. m7G modifications are pivotal in human diseases, particularly cancer progression.

Extracellular matrix stiffness regulates colorectal cancer progression via HSF4.

Background: Colorectal cancer (CRC) has high incidence and mortality rates, with severe prognoses during invasion and metastasis stages. Despite advancements in diagnostic and therapeutic technologies, the impact of the tumour microenvironment, particularly extracellular matrix (ECM) stiffness, on CRC progression and metastasis is not fully understood.

Methods: This study included 107 CRC patients.

The triglyceride-glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with machine learning analysis.

Background: Hypertension (HTN) is a global public health concern and a major risk factor for cardiovascular disease (CVD) and mortality. Insulin resistance (IR) plays a crucial role in HTN-related metabolic dysfunction, but its assessment remains challenging. The triglyceride-glucose (TyG) index and its derivatives (TyG-BMI, TyG-WC, and TyG-WHtR) have emerged as reliable IR markers.

Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover trial.

Background: Guidelines recognized dual combination in initial antihypertensive therapy. Studies found that low-dose quadruple combination were superior to monotherapy. However, whether low-dose quadruple therapy is better than dual combination is unknown.

East Asian expatriate football players and national team success: Chinese, Japanese, and South Korean players in Europe (2000-2024).

This study investigated the influence of Chinese, Japanese, and South Korean football players' participation in European leagues on their national teams' FIFA rankings from 2000 to 2024. Utilizing data from 22,972 matches featuring 392 players across 36 European leagues and 12 tournaments or cup competitions, survival and conditional process analyses were conducted to explore the relationships between expatriate player counts, appearances, playing time, and FIFA rankings. The results demonstrated a significant correlation between the number of expatriate players, particularly in top-tier leagues, and national team rankings.

Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial.

Objective: To test the hypothesis that a freeze-all strategy would increase the chance of live birth compared with fresh embryo transfer in women with low prognosis for in vitro fertilisation (IVF) treatment.

Design: Pragmatic, multicentre, randomised controlled trial.

Setting: Nine academic fertility centres in China.

Genomes reveal pervasive distant hybridization in nature among cyprinid fishes.

Background: Genomic data have unveiled a fascinating aspect of the evolutionary past, showing that the mingling of different species through hybridization has left its mark on the histories of numerous life forms. However, the relationship between hybridization events and the origins of cyprinid fishes remains unclear.

Results: In this study, we generated de novo assembled genomes of 8 cyprinid fishes and conducted phylogenetic analyses on 24 species.

TPepRet: a deep learning model for characterizing T cell receptors-antigen binding patterns.

Motivation: T-cell receptors (TCRs) elicit and mediate the adaptive immune response by recognizing antigenic peptides, a process pivotal for cancer immunotherapy, vaccine design, and autoimmune disease management. Understanding the intricate binding patterns between TCRs and peptides is critical for advancing these clinical applications. While several computational tools have been developed, they neglect the directional semantics inherent in sequence data, which are essential for accurately characterizing TCR-peptide interactions.

Emerging roles of hyaluronic acid hydrogels in cancer treatment and wound healing: A review.

Hyaluronic acid (HA)-derived hydrogels signify a noticeable development in biomedical uses, especially in cancer treatment and wound repair. Cancer continues to be one of the foremost causes of death globally, with current therapies frequently impeded by lack of specificity, serious side effects, and the emergence of resistance. HA hydrogels, characterized by their distinctive three-dimensional structure, hydrophilic nature, and biocompatibility, create an advanced platform for precise drug delivery, improving therapeutic results while minimizing systemic toxicity.

Unraveling the interaction of dissolved organic matter and microorganisms with internal phosphorus cycling in the floodplain lake ecosystem.

Internal nutrient cycling, especially phosphorus (P), is of great influence in lake eutrophication. Dissolved organic matter (DOM) and microorganisms are ubiquitous in the sediments and closely associated with P-cycling. However, the underlying interactions of DOM, microorganisms and P in floodplain lake area with different hydrological characteristics remain scarce.

Enhancing single-stage partial nitritation-anammox process with airlift inner-circulation and oxygen partition: a novel strategy for treating high-strength ammonium wastewater.

In the single-stage partial nitritation-anammox process for high-ammonium wastewater treatment, the presence of sufficient biomass with high activity is essential. This study developed an innovative airlift inner-circulation partition bioreactor (AIPBR) with a dual-cylinder structure. During the 362 days' operation, the AIPBR exhibited robust and stable nitrogen removal performance under diverse influent ammonium spanning from 300 to 1800 mg N/L.

Massively parallel Hong-Ou-Mandel interference based on independent soliton microcombs.

Hong-Ou-Mandel (HOM) interference is the foundation of quantum optics to test the degree of indistinguishability of two incoming photons, playing a key role in quantum communication, sensing, and photonic quantum computing. Realizing high-visibility HOM interference with massively parallel optical channels is challenging due to the lack of available natural optical references for aligning independent arrayed laser pairs. Here, we demonstrate 50 parallel comb-teeth pairs of continuous-wave weak coherent photons HOM interference using two independently frequency post-aligned soliton microcombs (SMCs), achieving an average fringe visibility over 46%.

Measurement of population agglomeration, dynamic change characteristics, and motivations in metropolitan agglomerations-A case study of the Xi'an metropolitan area.

This article compares the population agglomeration characteristics of the Xi'an metropolitan area in western China with those of metropolitan areas in other regions officially approved by the Chinese government. The kernel density estimation method and Markov chain model were used to conduct the study. The results revealed that from 2010 to 2020, the population agglomeration level of the Xi'an metropolitan area showed a trend of first increasing and then decreasing.

Precise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.

Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.