Apple MIEL1/ABI5-MAX2 regulatory module links strigolactone and abscisic acid signals.

In apple (Malus domestica), the abscisic acid (ABA)-responsive factor ABA INSENSITIVE5 directly activates MORE AXILLARY GROWTH2 (MdMAX2), an important strigolactone signaling component; an abscisic acid-restricted E3 ubiquitin ligase modulates MdMAX2 turnover, thus linking strigolactone and abscisic acid signaling.

In Situ Cascade Catalytic Polymerization of Dopamine Based on Pt NPs/CoSAs@NC Nanoenzyme for Constructing Highly Sensitive Photocurrent-Polarity-Switching PEC Biosensing Platform.

Nanozymes open up new avenues for amplifying signals in photoelectrochemical (PEC) biosensing, which are yet limited by the generated small-molecule signal reporters. Herein, a multifunctional nanoenzyme of Pt NPs/CoSAs@NC consisting of Co single atoms on N-doped porous carbon decorated with Pt nanoparticles is successfully synthesized for cascade catalytic polymerization of dopamine for constructing a highly sensitive photocurrent-polarity-switching PEC biosensing platform. Taking protein tyrosine phosphatase 1B (PTP1B) as a target model, Pt NPs/CoSAs@NC nanoenzymes are linked to magnetic microspheres via phosphorylated peptides.

A perspective on field-effect in energy and environmental catalysis.

The development of catalytic technologies for sustainable energy conversion is a critical step toward addressing fossil fuel depletion and associated environmental challenges. High-efficiency catalysts are fundamental to advancing these technologies. Recently, field-effect facilitated catalytic processes have emerged as a promising approach in energy and environmental applications, including water splitting, CO reduction, nitrogen reduction, organic electrosynthesis, and biomass recycling.

Latent profiles of problem-solving skills and their association with depressive symptoms in parents of children with cancer: A cross-sectional study.

Objective: Depressive symptoms are prevalent among parents of children with cancer, significantly impacting their well-being. Problem-solving skills, strongly linked to depressive symptoms, offer a promising avenue for intervention. This study aimed to identify latent profiles of parental problem-solving skills and evaluate differences in depressive symptoms across these profiles.

Cost-effectiveness analysis of first-line combination chemotherapy regimens for metastatic pancreatic cancer and evidence-based pricing strategy of liposomal irinotecan in China.

Background: The phase III NAPOLI-3 trial, which upgraded FOLFIRINOX (leucovorin, fluorouracil, irinotecan and oxaliplatin) to NALIRIFOX (liposomal irinotecan, oxaliplatin, leucovorin, and fluorouracil), demonstrated the superiority of NALIRIFOX over GEMNABP (gemcitabine and nab-paclitaxel) as the first-line treatment for metastatic pancreatic ductal adenocarcinoma. The purpose of this study was to assess the cost-effectiveness of NALIRIFOX, FOLFIRINOX, and GEMNABP, and to simulate the price of liposomal irinotecan at which NALIRIFOX could achieve cost-effectiveness.

Methods: A partitioned survival model was performed to evaluate the cost-effectiveness of NALIRIFOX, FOLFIRINOX and GEMNABP from the perspective of the Chinese healthcare system.

Corrigendum: Bibliometric analysis of research on digestive system tumors and depression.

[This corrects the article DOI: 10.3389/fpsyg.2024.

GLNet: global-local feature network for wheat leaf disease image classification.

Addressing the issues with insufficient multi-scale feature perception and incomplete understanding of global information in traditional convolutional neural networks for image classification of wheat leaf disease, this paper proposes a global local feature network, i.e. GLNet, which adopts a unique global-local convolutional neural network architecture, realizes the comprehensive capturing of multi-scale features in an image by processing the global feature block and local feature block in parallel and integrating the information of both of them with the help of a feature fusion block.

Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study.

Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.

Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.

Artificial intelligence in precision medicine for lung cancer: A bibliometric analysis.

Background: The increasing body of evidence has been stimulating the application of artificial intelligence (AI) in precision medicine research for lung cancer. This trend necessitates a comprehensive overview of the growing number of publications to facilitate researchers' understanding of this field.

Method: The bibliometric data for the current analysis was extracted from the Web of Science Core Collection database, CiteSpace, VOSviewer ,and an online website were applied to the analysis.

Traditional Uses, Phytochemistry, Pharmacology and Toxicology of : A Critical Review and Future Perspectives.

Medicinal plants are fundamental sources of natural products with high chemical diversity and specificity as novel lead compounds with diverse pharmacological activities. . is an important traditional Chinese medicine used to treat fever caused by cold, wind-fire toothache, headache, bruises and sprains, irregular menstruation, and infantile eczema.

Comparative genetic analysis of blood and semen samples in sperm donors from Hunan, China.

Objectives: At present, most genetic tests or carrier screening are performed with blood samples, and the known carrier rate of disease-causing variants is also derived from blood. For semen donors, what is really passed on to offspring is the pathogenic variant in their sperm. This study aimed to determine whether pathogenic variants identified in the sperm of young semen donors are also present in their blood, and whether matching results for blood are consistent with results for sperm.

Predicting Antidepressant Treatment Response From Cortical Structure on MRI: A Mega-Analysis From the ENIGMA-MDD Working Group.

Accurately predicting individual antidepressant treatment response could expedite the lengthy trial-and-error process of finding an effective treatment for major depressive disorder (MDD). We tested and compared machine learning-based methods that predict individual-level pharmacotherapeutic treatment response using cortical morphometry from multisite longitudinal cohorts. We conducted an international analysis of pooled data from six sites of the ENIGMA-MDD consortium (n = 262 MDD patients; age = 36.

Organic Metasurfaces with Contrasting Conducting Polymers.

Conducting polymers have emerged as promising active materials for metasurfaces due to their electrically tunable states and large refractive index modulation. However, existing approaches are often limited to infrared operation or single-polymer systems, restricting their versatility. In this Letter, we present organic metasurfaces featuring dual conducting polymers, polyaniline (PANI) and poly(3,4-ethylenedioxythiophene) (PEDOT), to achieve contrasting dynamic optical responses at visible frequencies.

More envy, more loneliness? not only that: A longitudinal study and daily diary study.

Although cross-sectional studies have explored the correlation between envy and loneliness, few longitudinal studies have investigated the bidirectional association between envy and loneliness at both trait and state levels. Here, through a longitudinal study and a daily diary investigation, we examined the interrelationships between envy and loneliness at both trait and state levels. In study 1, 288 college students answered the Dispositional Envy Scale (DES) and UCLA Loneliness Scale (UCL-8 Scale) twice with a one-year interval.

N,O Co-Doped Carbon Spheres Enable Stable Anode-Less Sodium Metal Batteries.

Anode-less sodium metal batteries (SMBs) suffer from the formation of Na dendrites and inactive Na on an anode substrate though showing advantages of high energy densities and low costs. Herein, N,O co-doped carbon spheres (NOCS), which are synthesized via a scalable polymerization and pyrolysis method, are employed as a thin and stable sodiophillic nucleation layer on the Cu foil. Combined with electrochemical measurements, Na deposition morphology observations and density functional theory calculations, it is revealed that the introduced N and O heteroatoms can greatly enhance the adsorption of Na on the carbon substrate and reduce the nucleation overpotential, thus forming sufficient seeding sites and guiding homogeneous Na deposition.

Porphyrin-Based Metal-Organic Framework Photocatalysts: Structure, Mechanism and Applications.

In recent years, porphyrins have been frequently reported as photocatalysts due to their fascinating photochemical properties. However, porphyrins have the same shortcomings as other homogeneous photocatalysts, such as poor stability and difficulty in recovering. To solve this problem, it is a good strategy to form a porphyrin-based metal-organic framework (PMOF) by modifying porphyrin functional groups and adding metals as nodes to connect and control the arrangement of porphyrins.

Microwave-Sintered Nano-SiC Reinforced 8SiC/Ti-3Cu Composite: Fabrication, Wear Resistance, Antibacterial Function, and Biocompatibility.

The significance of biomedical applications of Ti alloys is best emphasized by their widespread utilization as implantable materials, such as internal supports and bone replacements. Ti alloys are sensitive to fretting wear, which leads to the early failure of Ti implants. Improved wear resistance of such implants is essential to ensure a prolonged implant life.

The bidirectional relationship between perceived social support and moral sensitivity in adolescents: Evidence from longitudinal study and weekly diary method.

Introduction: Moral sensitivity, the ability to perceive moral issues, plays a crucial role in societal development and progress. Previous studies have highlighted the significance of perceived social support as a key factor influencing moral sensitivity.

Method: Based on the conservation of resources theory, this pioneering study investigates the association between perceived social support and moral sensitivity at both trait and state levels, employing a longitudinal study and a weekly diary method.

A phase II trial of anlotinib plus EGFR-TKIs in advanced non-small cell lung cancer with gradual, oligo, or potential progression after EGFR-TKIs treatment (CTONG-1803/ALTER-L001).

Background: The study is to evaluate the efficacy and safety of combined anlotinib and EGFR-tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC) who had gradual, oligo, or potential progression after previous EGFR-TKIs treatment.

Methods: We conducted an open-label, single-arm, multicenter, phase II trial in China. Eligible patients were 18-75 years old with histologically or cytologically confirmed NSCLC who were EGFR mutation positive and showed gradual, oligo, or potential progression after EGFR-TKIs.