Photo-Facilitated Nitric Oxide-Triggered Turn-on Photodynamic Therapy for Precise Antitumor Application.

Photodynamic therapy (PDT) is a powerful strategy for tumor therapy with noninvasiveness and desirable efficacy. However, the phototoxicity of photosensitizer after the post-PDT is the major obstacle limiting the clinic applications. Herein, a nitric oxide (NO)-activatable photosensitizer is reported with turn-on PDT behavior and endoplasmic reticulum (ER) targeting ability for precise tumor therapy.

Effects of exercise on bone mass and bone metabolism in adolescents: a systematic review and meta-analysis.

Objective: Meta-analysis was used to evaluate the effects of an exercise intervention on bone mineral content (BMC), bone mineral density (BMD), and bone metabolism in adolescents.

Methods: A systematic search of PubMed, Embase, Cochrane Library, and Web of Science for RCTs on "exercise, adolescents, BMD, bone metabolism" up to 10 September 2024. Included RCTs focused on effects of exercise on BMC, BMD, and bone metabolism in 10-19 years old, with physical activity as exercise group and daily living/primal exercise as control group.

Efficacy of Hongjing I granule, an herbal medicine, in patients with mild to moderate erectile dysfunction in a randomized controlled trial.

Background: HJIG is a potential treatment for erectile dysfunction (ED) that has been used in China for over 20 years. We conducted a multi-center, double-blind, randomized, placebo-controlled trial to evaluate the effectiveness and safety of the Chinese Herbal Medicine, Hongjing I granule (HJIG), in patients with mild to moderate erectile dysfunction (ED).

Methods: This study is structured as a randomized, double-blind, placebo-controlled trial, executed across multiple centers.

Effects of combined Bacillus coagulans and Yeast fermentation culture on growth performance, plasma biochemical indices, intestinal morphology and microbial of broilers.

The favorable impacts of Bacillus coagulans or Yeast culture on broiler production performance and immune function have been acknowledged. However, the effects of the combined of them (BcYc) on the broilers remained unknown. Thus, the current research aimed to assess the effects of BcYc (at dosages of 0, 200, 300, and 400 mg/kg) on growth performance, plasma biochemical indices, antioxidant capacity, and intestinal morphology and microbial composition in broilers.

Supramolecular transparent plastic engineering covalent-and-supramolecular polymerization.

Supramolecular glass and plastic are a new generation of artificial transparent materials that exhibit excellent optical behavior and processability. However, owing to inherent deficiencies in their mechanical toughness and long-term stability, supramolecular materials lack the potential for functionalization and application. Inspired by the toughening phenomena in biological systems, a synergistic covalent-and-supramolecular polymerization strategy was applied to construct plastic-like supramolecular materials with high transmittance the solvent-free one-pot amidation of thioctic acid and (poly)amines.

Fecal Microbiota Transplantation Alleviates Airway Inflammation in Asthmatic Rats by Increasing the Level of Short-Chain Fatty Acids in the Intestine.

Asthma is a prevalent chronic inflammatory disorder of the respiratory tract that not only manifests with respiratory symptoms but also often involves intestinal flora disorders and gastrointestinal dysfunction. Recent studies have confirmed the close relationship between the gut and lungs, known as the "gut-lung axis" theory. Fecal microbiota transplantation (FMT), a method for restoring normal intestinal flora, has shown promise in treating common gastrointestinal diseases.

A prognostic index for advanced-stage extranodal natural killer/T-cell lymphoma: A multicenter study.

Advanced-stage extranodal natural killer/T-cell lymphoma (ENKTL) is a highly heterogeneous disease with very poor prognosis. All commonly utilized prognostic models incorporated both early-stage and advanced-stage patients in the modeling process. This study aim to design a prognostic model specifically for advanced-stage ENKTL, providing risk stratification in affected patients.

The lexical profile of forestry academic texts: What does it take to understand a specialized discipline?

Vocabulary is essential for comprehension, especially in specialized disciplines. However, the research on the lexical features of forestry remains underexplored. This study focuses on the vocabulary frequency profile of forestry academic texts, and compares forestry vocabulary with general vocabulary and general academic vocabulary.

Evaluation of Auricular Acupressure on Myopia Prevention among Children Aged 6-12 Years with Pre-Myopia in China: Study Protocol of a Prospective Multi-Center Randomized Controlled Trial.

Background: The increasing prevalence of myopia among Chinese children and adolescents, especially at younger ages, has emerged as a significant concern in recent years. Pre-myopia is a key period for myopia prevention and control in children and adolescents. Previous studies suggested auricular acupressure (AA) therapy might offer a viable approach to prevent and slow down myopia progression.

Metformin and the risk of malignant tumors of digestive system: a mendelian randomization study.

Background: Observational studies suggest that metformin may reduce the risk of malignant tumors of the digestive system (MTDS), but these findings are often confounded by bias and unmeasured variables. Recent meta-analyses have questioned these associations, emphasizing the need for robust causal inference.

Methods: Mendelian randomization (MR) was used to evaluate the causal relationship between metformin and MTDS.

CDPMF-DDA: contrastive deep probabilistic matrix factorization for drug-disease association prediction.

The process of new drug development is complex, whereas drug-disease association (DDA) prediction aims to identify new therapeutic uses for existing medications. However, existing graph contrastive learning approaches typically rely on single-view contrastive learning, which struggle to fully capture drug-disease relationships. Subsequently, we introduce a novel multi-view contrastive learning framework, named CDPMF-DDA, which enhances the model's ability to capture drug-disease associations by incorporating diverse information representations from different views.

Translation, cross-cultural adaptation and validation of the Chinese version of supportive and palliative care indicators tool (SPICT-CH) to identify cancer patients with palliative care needs.

Introduction: People diagnosed with cancer are the most frequent users of palliative care. However, there are no specific standards for early identifying patients with palliative care needs in mainland China. The Supportive and Palliative Care Indicators tool (SPICT) can identify patients with cancer who are in need of palliative care across healthcare settings.

Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner.

Chronic stress can result in various conditions, including psychological disorders, neurodegenerative diseases, and accelerated brain aging. Gut dysbiosis potentially contributes to stress-related brain disorders in individuals with chronic stress. However, the causal relationship and key factors between gut dysbiosis and brain disorders in chronic stress remain elusive, particularly under non-sterile conditions.

A Self-Phase Separated Electrolyte toward Durable and Rollover-Stable Zinc Metal Batteries.

Aqueous zinc (Zn) metal batteries (ZMBs) have received great attention due to their safety and environmental friendliness. Although aqueous electrolytes facilitate fast kinetics in metal oxide cathodes, their incompatibility with the Zn metal anodes triggers severe hydrogen evolution reaction (HER) and dendrite growth. Herein, a self-phase separated electrolyte (SPSE) is proposed to fulfill the contradictory requirements of the anode and cathode in ZMBs.

DNA Self-Assembly Generated by Aptamer-Triggered Rolling Circle Amplification Cascades for Profiling Colorectal Cancer-Derived Small Extracellular Vesicles.

The analysis of small extracellular vesicles (sEVs) has shown clinical significance in early cancer diagnostics and considerable potential in prognostic assessment and therapeutic monitoring, offering possibilities for precise clinical intervention. Despite recent diagnostic progress based on blood-derived sEVs, the inability to specifically profile multiple parameters of sEVs proteins has hampered advancement in clinical applications. Herein, we report an approach to profile colorectal cancer (CRC)-derived sEVs by using multiaptamer-triggered rolling circle amplification (RCA) cascades.

Microfluidics for Nanomedicine Delivery.

Nanomedicine is revolutionizing precision medicine, providing targeted, personalized treatment options. Lipid-based nanomedicines offer distinct benefits including high potency, targeted delivery, extended retention in the body, reduced toxicity, and lower required doses. These characteristics make lipid-based nanoparticles ideal for drug delivery in areas such as gene therapy, cancer treatment, and mRNA vaccines.

A Hybrid Harmonic Curve Model for Multi-Streamer Hydrophone Positioning in Seismic Exploration.

Towed streamer positioning is a vital and essential stage in marine seismic exploration, and accurate hydrophone coordinates exert a direct and significant influence on the quality and reliability of seismic imaging. Current methods predominantly rely on analytical polynomial models for towed streamer positioning; however, these models often produce significant errors when fitting to streamers with high curvature, particularly during turning scenarios. To address this limitation, this study introduces a novel multi-streamer analytical positioning method that uses a hybrid harmonic function to model the three-dimensional coordinates of streamers.

A Time-Frequency-Based Data-Driven Approach for Structural Damage Identification and Its Application to a Cable-Stayed Bridge Specimen.

Structural damage identification based on structural health monitoring (SHM) data and machine learning (ML) is currently a rapidly developing research area in structural engineering. Traditional machine learning techniques rely heavily on feature extraction, where weak feature extraction can lead to suboptimal features and poor classification performance. In contrast, ML-based methods, particularly deep learning approaches like convolutional neural networks (CNNs), automatically extract relevant features from raw data, improving the accuracy and adaptability of the damage identification process.

Precisely Tailoring Molecular Structure of Doxorubicin Prodrugs to Enable Stable Nanoassembly, Rapid Activation, and Potent Antitumor Effect.

Background: Achieving a balance between stable drug loading/delivery and on-demand drug activation/release at the target sites remains a significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on the design of prodrug molecules, offer a promising strategy to optimize both drug delivery efficiency and controlled drug release profiles.

Methods: A library of doxorubicin (DOX) prodrugs was created by linking DOX to fatty alcohols of varying chain lengths via a tumor-responsive disulfide bond.

Cumulative Strain and Improvement Mechanisms of Soil Reinforced by Xanthan Gum Biopolymer Under Traffic Loading.

As is widely accepted, cumulative strain and improvement mechanisms of stabilized soil are critical factors for the long-term reliable operation of expressways and high-speed railways. Based on relevant research findings, xanthan gum biopolymer is regarded as a green and environmentally friendly curing agent in comparison to traditional stabilizers, such as cement, lime, and fly ash. However, little attention has been devoted to the cumulative strain and improvement mechanisms of soil reinforced by xanthan gum biopolymer under traffic loading.

High-Stretchable and Transparent Ultraviolet-Curable Elastomer.

This work introduces an ultraviolet (UV)-curable elastomer through the co-polymerization of aliphatic polyurethane acrylate and hydroxypropyl acrylate via UV irradiation. The UV-curable elastomer presents superior mechanical properties (elongation at a break of 2992%) and high transparency (94.8% at 550 nm in the visible light region).

Effects of Different Processing on miRNA and Protein in Small Extracellular Vesicles of Goat Dairy Products.

Objectives: Small extracellular vesicles (sEVs) are nanosized vesicles with biological activities that exist in milk, playing functional roles in immunity, gut balance, and the nervous system. Currently, little is known about the impact of processing on milk sEVs.

Methods: In this study, sEVs were collected from raw goat milk (g-sEV), pasteurized goat milk (pg-sEV), and goat milk powder (-sEV) using a sucrose cushion centrifugation combined with qEV chromatography.

Mosla Chinensis Extract Enhances Growth Performance, Antioxidant Capacity, and Intestinal Health in Broilers by Modulating Gut Microbiota.

This study aimed to evaluate the effects of Mosla chinensis extract (MCE) on broiler intestinal health. A total of 240 1-day-old Arbor Acres (AA) broilers (balanced for sex) were randomly allocated into four treatment groups, each with six replicates of 10 chickens. The study comprised a starter phase (days 1-21) and a grower phase (days 22-42).

Planted Citrus Regulates the Community and Networks of -Harboring Bacteria to Drive Phosphorus Availability Between Karst and Non-Karst Soils.

The phosphorus (P) availability in soils is influenced by microbes, particularly those containing the gene responsible for phosphate solubilization. The present study investigated the community structure, diversity, and co-occurrence networks of -harboring bacteria in karst and non-karst citrus orchard soils across a planting duration gradient, natural forests, and abandoned land, as well as the soil total P (TP) and available P (AP) contents and enzyme activities. The soil AP contents were lower in the karst regions than in the non-karst regions, while the soil organic carbon (C; SOC), exchangeable calcium, and microbial biomass nitrogen (N) contents; alkaline phosphatase (ALP) and β-Glucuronidase activities; and pH had the opposite trends.

Effects of Biological Nitrogen Fixation and Nitrogen Deposition on Soil Microbial Communities in Karst Grassland Ecosystems.

Diverse exogenous nitrogen (N) sources have a considerable impact on microbial community structure in terrestrial ecosystems. Legume plants and N deposition can relieve N limitations and increase net primary productivity. However, the differences in their effects on soil microbial communities remain unclear.