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Insulin-like growth factor-2 antisense oligonucleotides inhibits myopia by expression blocking of retinal insulin-like growth factor-2 in guinea pig.
Clin Exp Ophthalmol
July 2012
Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha Eye Center, Changsha, China.
Objective: To clarify the role of IGF-2 on the development of myopia, the dynamic expression of IGF-2 was investigated in the FD eyes' retina, and the effects of intravitreous injection with IGF-2 ASON was studied on the diopter and axial eye length of FD eyes.
Methods: 64 guinea pigs were divided into 2 groups. In group A (n = 24), the right eyes were covered.