Photoinduced copper catalyzed nitrogen-to-alkyl radical relay Sonogashira-type coupling of -alkylbenzamides with alkynes.

This report describes a copper-catalyzed, photoinduced -to-alkyl radical relay Sonogashira-type reactions at benzylic sites in -alkylbenzamides with alkynes. The process employs an -to-alkyl radical mechanism, initiated through the copper-catalyzed reductive generation of nitrogen radicals. Radical translocation is facilitated by a 1,5-hydrogen atom transfer (1,5-HAT), leading to the formation of translocated carbon radicals.

Palladium-catalyzed alkynylation of allylic -difluorides.

Herein, a palladium-catalyzed regioselective alkynylation, esterification, and amination of allylic -difluorides C-F bond activation/transmetallation/β-C elimination or nucleophilic attack has been achieved. This innovative protocol showcases an extensive substrate range and operates efficiently under mild reaction conditions, resulting in high product yields and -selectivity. Particularly noteworthy is its exceptional tolerance towards a wide array of functional groups.

Photoinduced radical cascade domino Heck coupling of -aryl acrylamide with vinyl arenes enabled by palladium catalysis.

Here, a redox-neutral palladium-catalyzed photo-induced radical cascade domino Heck reaction of -aryl acrylamide with vinyl arenes is described. A diverse range of bioactive oxindoles, featuring an all-carbon quaternary center, were synthesized. The reaction is proposed to proceed an open-shell intermediate and occurs under mild reaction conditions, exhibiting excellent functional group tolerance.

[Study on classification and identification of depressed patients and healthy people among adolescents based on optimization of brain characteristics of network].

To enhance the accuracy of computer-aided diagnosis of adolescent depression based on electroencephalogram signals, this study collected signals of 32 female adolescents (16 depressed and 16 healthy, age: 16.3 ± 1.3) with eyes colsed for 4 min in a resting state.

Synthesis of phenanthridine derivatives via cascade annulation of diaryliodonium salts and nitriles.

A cascade coupling reaction toward a variety of phenanthridine derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction of diaryliodonium salts and nitriles, and undergoes cyclization into the phenanthridine core.

Mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde.

A mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde has been developed, which provides a practical synthetic strategy for the synthesis of indole derivatives.

Gold(III)-catalyzed three-component coupling reaction (TCC) selective toward furans.

An efficient three-component coupling reaction toward a variety of furan derivatives has been developed. This cascade transformation proceeds via the gold-catalyzed coupling reaction of phenylglyoxal derivatives, secondary amines, and terminal alkynes, under the reaction conditions, that undergoes cyclization into the furan core.