3 results match your criteria: "Chang Gung University Taoyuan 33305[Affiliation]"
A patient-derived xenograft mouse platform from epithelioid glioblastoma provides possible druggable screening and translational study.
Am J Cancer Res
October 2024
Department of Medicine, Chang Gung University Taoyuan 33305, Taiwan.
Article Synopsis
- Glioblastoma is a difficult-to-treat brain cancer with a low survival rate, despite improvements in surgical and radiation therapies.
- Epithelioid glioblastoma (eGBM) is a rare subtype where patient-derived xenograft (PDX) models in mice show potential for drug testing and research, indicating consistent genetic abnormalities across tumors.
- Recent studies using PDX models identified effective treatments, like Palbociclib and Dabrafenib/Trametinib, which significantly reduced tumor size and highlighted the importance of continuing research for better diagnosis and treatment options.
Paraneoplastic leukocytosis induces NETosis and thrombosis in bladder cancer PDX model.
Am J Cancer Res
August 2024
Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
Article Synopsis
- Paraneoplastic leukocytosis (PNL) in genitourinary cancer may signal aggressive disease and poor prognosis, potentially linked to G-CSF and GM-CSF expression in tumors.
- The study created four patient-derived xenograft lines from urothelial cancer, finding that one line (UC-PDX-LN1) had two effective druggable targets and correlated PNL with the patient’s original tumor, suggesting a mechanism of enhanced tumor growth through secreted growth factors.
- The research indicates that combining chemotherapy with interventions targeting neutrophil activity and thrombosis may improve treatment outcomes for bladder cancer patients with PNL.
Injectable hydrogels in regeneration medicine can potentially mimic hierarchical natural living tissue and fill complexly shaped defects with minimally invasive implantation procedures. To achieve this goal, however, the versatile hydrogels that usually possess the nonporous structure and uncontrollable spatial agent release must overcome the difficulties in low cell-penetrative rates of tissue regeneration. In this study, an adaptable microporous hydrogel (AMH) composed of microsized building blocks with opposite charges serves as an injectable matrix with interconnected pores and propagates gradient growth factor for spontaneous assembly into a complex shape in real time.
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