4 results match your criteria: "Chang Gung University 333[Affiliation]"
Knockdown of EPS8 expression attenuates the proliferation of enzalutamide-resistant prostate cancer cells.
Am J Cancer Res
October 2024
Division of Urology, Department of Surgery, E-Da Hospital Kaohsiung 824, Taiwan.
Androgen deprivation therapies, the key treatment options for prostate cancer, have shown resistance and disease progression in many patients receiving these treatments. Therefore, it is crucial to identify new targetable pathways. Epidermal growth factor receptor pathway substrate 8 (Eps8) is one such potential target.
View Article and Find Full Text PDFOral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury.
Cell Rep
January 2024
Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan, Linkou 333, Taiwan; Grandulate Institute of Clinical Medicine, College of Medicine, Chang Gung University 333, Taoyuan, Taiwan. Electronic address:
Article Synopsis
- Oral fecal microbiota transplantation (FMT) via capsules is gaining traction as a more convenient treatment option, but the effectiveness of microbe selection in the upper gastrointestinal tract remains unknown.
- Short-term oral fecal gavage (OFG) in mice shows promise in reducing acetaminophen-induced acute liver injury (AILI), with similar effects observed from pasteurized fecal gavage.
- Improved survival rates for mice with AILI are linked to the enrichment of beneficial gut microbes and metabolites like butyrate, suggesting oral administration's significant role in treating liver injuries through gut microbe modulation.
Compositional and functional variations of oral microbiota associated with the mutational changes in oral cancer.
Oral Oncol
February 2018
Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung 204, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, 333, Taiwan. Electronic address:
Objectives: Both genetic and environmental factors are conceivably required to assess the prognosis of oral squamous cell carcinoma (OSCC), yet little is known regarding the relationship between oral microbiome and the mutational spectrum of OSCC.
Materials And Methods: Here, we used 16S rRNA amplicon sequencing to study the composition of oral microorganisms in OSCC patients, whose cancer mutational profiles were previously defined by whole-exome sequencing, to evaluate the relationship between oral microbiome and the mutational changes in OSCC.
Results: Analyzing the contributions of the five mutational signatures extracted from the primary tumors revealed three groups of OSCC (mutational signature cluster, MSC1-3) that were significantly associated with demographic and clinical features.
Singular observation of the polarization-conversion effect for a gammadion-shaped metasurface.
Sci Rep
February 2016
Department of Material Science and Engineering, National Tsing Hua University 300 Hsinchu, Taiwan.
In this article, the polarization-conversion effects of a gammadion-shaped metasurface in transmission and reflection modes are discussed. In our experiment, the polarization-conversion effect of a gammadion-shaped metasurface is investigated because of the contribution of the phase and amplitude anisotropies. According to our experimental and simulated results, the polarization property of the first-order transmitted diffraction is dominated by linear anisotropy and has weak depolarization; the first-order reflected diffraction exhibits both linear and circular anisotropies and has stronger depolarization than the transmission mode.
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