2,683 results match your criteria: "Chang Gung Memorial Hospital at Linkou.[Affiliation]"

Background: Worldwide patient-caregiver concordance on cognitive prognostic awareness (PA) has been extensively examined, but concordance on sufficient (ie, cognitive and emotional) death preparedness is unexplored. We comprehensively examine the evolution of patient-caregiver concordance on death preparedness over the patient's last 6 months.

Materials/methods: This study re-examined data from 2 cohort studies on 694 dyads of cancer patients and their caregivers recruited from a single medical center in Taiwan.

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Exploring foreign language anxiety and resting-state EEG alpha asymmetry.

Brain Lang

December 2024

Department of Electrical Engineering, Chang Gung University, 259 Wen-Hwa 1st Road, Guishan Dist., Taoyuan City 333, Taiwan, ROC.

Anxiety experienced when interacting in a foreign language hinders communication through detrimental behavioral, cognitive, and somatic effects. Despite its impact, there is limited research on how neural asymmetry relates to foreign language anxiety (FLA). While researchers have investigated FLA through brain imaging, there remains an absence of studies examining its correlation with frontal alpha asymmetry.

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Aims: Chronic pain is a critical public health issue that severely impacts quality of life and poses significant treatment challenges, particularly due to the risk of adverse effects associated with pharmacological therapies. The search for effective non-invasive treatment alternatives has become increasingly relevant. Low-intensity focused ultrasound (LIFU) has been identified as an effective non-invasive strategy for pain management, although the underlying mechanism remains unclear.

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Background: Pediatric supracondylar humeral fractures present considerable surgical challenges due to the difficulty of achieving proper fracture alignment and stable fixation while avoiding injury to the ulnar nerve. This study assesses the biomechanical performance of a novel Kirschner wire (K-wire) fixation device (KFD), designed to enhance stability and reduce complications linked to traditional K-wire configurations.

Methods: Using finite element analysis (FEA), we evaluated four fixation strategies for treatment of pediatric supracondylar humeral simple transverse fractures: crossed pin fixation, crossed pin fixation with KFD, two lateral pin fixation, and two lateral pin fixation with KFD, under various mechanical loads.

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Background: The phenotype of cryoglobulinemia in hepatitis B virus (HBV) carriers remains elusive.

Methods: A 7-year prospective cohort of 648 hepatitis B e antigen (HBeAg)-negative Taiwanese HBV carriers [males: 344 (53%)] was conducted.

Results: Among 648, 189 (29.

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Prophylaxis of topical levofloxacin against endophthalmitis after cataract surgery in Taiwan, 2001-2019: an interrupted time series analysis.

Int J Clin Pharm

December 2024

Department of Public Health, School of Medicine, College of Medicine, Chang Gung University, 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City, 33302, Taiwan.

Background: Since May 2007, topical levofloxacin 0.5% ophthalmic solution for prophylaxis of postoperative endophthalmitis (POE) in cataract surgery has been reimbursable in Taiwan.

Aim: We used the National Health Insurance Research Database to estimate the practice of levofloxacin in cataract surgery from 2001 to 2019 and compared the POE rates before and after the introduction of levofloxacin using interrupted time series (ITS) analysis.

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Article Synopsis
  • This study investigates the use of serum inflammatory markers as prognostic indicators for survival in patients with metastatic urothelial carcinoma (mUC) receiving immune checkpoint inhibitors (ICIs).
  • Data from two medical centers in Taiwan were analyzed, focusing on markers like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), to assess their impact on overall and progression-free survival.
  • The findings suggest that specific inflammatory markers, along with other clinical factors, can effectively predict patient outcomes, emphasizing the need for reliable prognostic tools in mUC treatment.
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The detection of fetal ultrasound standard planes (FUSPs) is important for the diagnosis of fetal malformation and the prevention of perinatal death. As a promising deep-learning technique in FUSP detection, SonoNet's network parameters have a large size. In this paper, we introduced a light pyramid convolution (LPC) block into SonoNet and proposed LPC-SonoNet with reduced network parameters for FUSP detection.

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Development and validation of the Taiwan Cancer Frailty Tool for older patients with cancer: A prospective longitudinal study.

J Geriatr Oncol

December 2024

Department of Hematology and Oncology, Geriatric Medical Center, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Introduction: The increasing occurrence of cancer in Taiwan's older population highlights the need for a culturally attuned frailty assessment tool. This study aimed to develop and validate a frailty screening instrument specifically designed for older Taiwanese patients with cancer to predict survival outcomes.

Materials And Methods: Patients aged ≥65 years newly diagnosed with cancer before treatment initiation at three Hospitals in Taiwan were prospectively included from July 2018 to December 2020 to participate in the study.

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Central vascular plug-assisted portal vein embolization with absolute ethanol.

Clin Radiol

November 2024

Department of Medical Imaging and Interventions, Chang Gung Memorial Hospital at Linkou, 5 FuXing Road, Guishan District, Taoyuan, 333, Taiwan. Electronic address:

Aim: Compare the efficacy and procedural efficiency of central vascular plug-assisted portal vein embolization (PVE) with absolute ethanol compared to selective PVE.

Materials And Methods: Between 2016 and 2023, patients who underwent ipsilateral percutaneous transhepatic PVE were included. Selective PVE involves serial cannulation and embolization of portal veins.

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The circadian rhythm controls a wide range of functions in the human body and is required for optimal health. Disruption of the circadian rhythm can produce inflammation and initiate or aggravate chronic diseases. The modern lifestyle involves long indoor hours under artificial lighting conditions as well as eating, working, and sleeping at irregular times, which can disrupt the circadian rhythm and lead to poor health outcomes.

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In an era of rapid digital development, e-learning has become a significant trend in the educational field. Medical technology students need to acquire extensive theoretical knowledge and practical skills. E-learning can enhance learning experiences, improving students' understanding and application abilities.

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Bereaved Family Quality of Life Varies With Comorbid Psychological Distress and ICU-Care Quality.

J Pain Symptom Manage

December 2024

Division of Hematology-Oncology (W.C.C., S.T.T.), Chang Gung Memorial Hospital at Linkou, Tao-Yuan, Taiwan, R.O.C.;; School of Nursing, Medical College (S.T.T.), Chang Gung University, Tao-Yuan, Taiwan, R.O.C.; Department of Nursing (S.T.T.), Chang Gung University of Science and Technology, Tao-Yuan, Taiwan, R.O.C.. Electronic address:

Context: Health-related quality of life (HRQOL) is highly endorsed, but HRQOL studies scarcely investigate the following: ICU family members; modifiable end-of-life (EOL) ICU-care factors; conjoint associations with prolonged grief disorder (PGD), post-traumatic stress disorder (PTSD), and depression; and long-term bereavement outcomes.

Objectives: Exploratorily investigate associations of PGD-PTSD-depressive-symptom states (resilient, subthreshold-depression dominant, PGD dominant, and PGD-PTSD-depression comorbid) and quality of EOL ICU care with families' HRQOL 6-24 months post loss.

Methods: This cohort study examined symptoms of PGD (11 items of the PG-13), PTSD (Impact of Event Scale-Revised), and depression (Hospital Anxiety and Depression Scale), and HRQOL (Medical Outcomes Study 36-Item Short-Form Health Survey) among 303 ICU family members.

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The authors reply.

Crit Care Med

December 2024

Department of International Business, Soochow University, Taipei, Taiwan, Republic of China.

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Triboelectric nanogenerators (TENGs) are devices that convert mechanical energy into electrical energy through the triboelectric effect, supplying power to a wide array of advanced sensing and monitoring systems. In this work, we utilized graphene-filled nanofibrous poly(vinylidene difluoride--hexafluoropropylene) (PVDF-HFP) as TENGs, employing electrospinning technology. We examined how the dielectric characteristics and transferred charge of the electrification mat affect the output of TENGs.

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Article Synopsis
  • - The text outlines a scoping review protocol aimed at investigating how gamification can enhance clinical reasoning skills in medical education by increasing engagement and knowledge retention in healthcare professionals.
  • - Using the Arksey and O'Malley framework and guidelines from the Joanna Briggs Institute, the review will systematically search major databases for relevant literature, focusing on studies that employ gamified strategies in clinical reasoning education.
  • - The findings will provide a synthesis of the different gamification methods used in the educational context, identify gaps in current research, and do so without requiring ethical approval, following established reporting guidelines to ensure transparency.
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Squamous cell carcinoma (SCC) of the ovary, an uncommon form of gynecologic cancer, typically originates from the malignant transformation of a pre-existing mature ovarian teratoma (MOT). However, due to its rarity, the molecular pathways driving its development are not well understood. To address this knowledge gap, we performed molecular inversion probe (MIP) array analysis and targeted sequencing of 275 cancer susceptibility genes on 11 ovarian SCC samples derived from MOTs.

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Pancreatic cancer is among the deadliest cancers, with a grim prognosis despite advances in treatment. We conducted a population-based case-control study from Taiwan, linking Health and Welfare Data Science Center data to the Taiwan Cancer Registry, which offers a promising strategy for its treatment through drug repurposing. The study aims to identify the association of anti-parkinsonian drugs with pancreatic cancer risk across different age groups.

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Article Synopsis
  • Liver transplantation is the main treatment for cirrhosis patients with hepatopulmonary syndrome (HPS), but its impact on survival rates is debated.
  • A study analyzed 181 liver transplant recipients, finding that 57.5% had HPS, with similar overall survival between HPS and non-HPS groups (around 69.8 vs 63.4 months).
  • Results showed that HPS patients experienced more post-surgery complications like delayed extubation and chest catheter insertion, but their overall survival was not negatively affected by HPS severity.
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An Ex vivo Cultivation Model for Circulating Tumor Cells: The Success Rate and Correlations with Cancer Response to Therapy.

Biomed J

November 2024

College of Medicine, Chang Gung University, Taoyuan, 333 Taiwan; Division of Hematology-Oncology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City, 236 Taiwan; Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, 333 Taiwan. Electronic address:

Article Synopsis
  • Cancer mortality is linked to recurrence and metastasis, making real-time tracking challenging due to current invasive methods, but circulating tumor cells (CTCs) may offer a non-invasive solution despite their scarcity.
  • A study validated a simple culture protocol to grow CTCs in a lab and analyzed how the growth of these cells correlates with clinical response in patients.
  • Results showed significant differences in CTC growth rates based on the patients’ disease status, indicating that CTC growth could be a useful predictor for cancer response and informing how long and under what conditions to observe them in culture.
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Objective: This study examined changes in nutritional status, fatigue, and quality of life, and identified longitudinal factors influencing changes in quality of life in patients with pancreatic cancer before and 12 months after surgery.

Methods: A longitudinal, correlational, single-group study was conducted on 89 patients with operable pancreatic cancer in Taiwan. Data were collected preoperatively (T0) and at 3 (T1), 6 (T2), and 12 (T3) months post-surgery using questionnaires- Mini Nutritional Assessment, Fatigue Symptom Inventory, and Functional Assessment of Cancer Therapy-General-and through bioelectrical impedance analysis, handgrip strength measurement, and the 30-s sit-to-stand test.

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Immediate effects of structured and natural deep breathing on heart rate variability and blood pressure in community-dwelling older adults.

Exp Gerontol

December 2024

Master Degree Program in Health and Long-term Care Industry, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Article Synopsis
  • The study explored how structured deep breathing (SDB) and natural deep breathing (NDB) affect heart rate variability (HRV) and blood pressure (BP) in older adults living independently.
  • Twenty-six older adults were randomly divided into two groups (SDB and NDB) and were evaluated for HRV and BP before, during, and after the breathing exercises.
  • Results indicated that both breathing techniques significantly improved HRV measures, enhancing parasympathetic activity without impacting blood pressure, suggesting that deep breathing can be a simple and effective way to support healthy aging.
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Article Synopsis
  • - The ESMO Clinical Practice Guidelines for oncogene-addicted metastatic non-small-cell lung cancer (mNSCLC) were updated into Pan-Asian adapted (PAGA) guidelines to better address the needs of Asian patients.
  • - A panel of experts from multiple Asian oncological societies collaborated to create these guidelines, focusing on scientific evidence rather than local treatment practices or drug availability.
  • - The guidelines aim to standardize the management of oncogene-addicted mNSCLC across Asia, while acknowledging regional differences in screening, treatment resources, and drug reimbursement policies.
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Article Synopsis
  • The study investigates the clinical features, treatment approaches, and long-term outcomes of patients with reflex epilepsies (RE) in Taiwan, particularly focusing on their responses to specific triggers.
  • A total of 81 patients were analyzed, revealing that those with extrinsic triggers (like photosensitivity) were generally younger and had more spontaneous seizures compared to those with intrinsic triggers (like Mah-Jong).
  • Results showed a high usage of antiseizure medications among patients, with a notable difference in treatment methods and stimulus avoidance behaviors between the two groups, but both achieved similar seizure control outcomes.*
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