Outcomes of upfront primary tumor resection in patients with synchronous wild-type metastatic colorectal cancer.

This multicenter study explored the survival benefits of upfront primary tumor resection (PTR) followed by first-line cetuximab plus chemotherapy in real-world patients with wild-type metastatic colorectal cancer (mCRC). Treatment options for mCRC include chemotherapy, targeted therapy, immunotherapy, and surgery. The efficacy of upfront PTR in managing mCRC remains unclear.

Augmented triboelectric properties of graphene-filled poly(vinylidene difluoride--hexafluoropropylene) (PVDF-HFP) nanofibers.

Triboelectric nanogenerators (TENGs) are devices that convert mechanical energy into electrical energy through the triboelectric effect, supplying power to a wide array of advanced sensing and monitoring systems. In this work, we utilized graphene-filled nanofibrous poly(vinylidene difluoride--hexafluoropropylene) (PVDF-HFP) as TENGs, employing electrospinning technology. We examined how the dielectric characteristics and transferred charge of the electrification mat affect the output of TENGs.

A Simple and Highly Specific MassARRAY-Based Stool DNA Assay to Prioritize Follow-up Decisions in Fecal Immunochemical Test-Positive Individuals.

Background: Seventy-five percent of fecal immunochemical test (FIT)-positive individuals are false positives and undergo unnecessary colonoscopies. Here, we established a stool DNA (sDNA) test that uses the Single Allele Base Extension Reaction (SABER) MassARRAY platform to improve the accuracy of FIT-based CRC detection.

Methods: Twenty-one variants in five CRC-associated genes were selected for the sDNA panel.