A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles a Key Intermediate of -Ethoxyvinyl Nitroaryls by Domino Rearrangement and Their Anti- Inflammatory Activity.

Background: Recently, there has been a lot of scientific interest in exploring the syntheses of oxygen and nitrogen-containing heterocyclic compounds due to their pharmacological activities. In addition, benzisoxazoles play a very important role in organic synthesis as key intermediates.

Objective: In this paper, we focused on developing a novel synthetic route for biologically active arylisoxazoles under normal conditions, and simplified it to get high purities and yields, and also reported their anti-inflammatory activities.