344 results match your criteria: "Centro Universitario de Ciencias Biológicas Y Agropecuarias[Affiliation]"

The Association of Anti-Sm with Osteopontin Related to Cognitive Impairment in a Pristane-Induced Lupus BALB/c Mice Model.

Int J Mol Sci

December 2024

Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.

The BALB/c model of pristane-induced lupus (PIL) exhibits cognitive impairment features resembling neuropsychiatric lupus (NPLSE). Osteopontin (OPN) is associated with disease activity in SLE; however, its involvement in NPLSE is not yet entirely determined. Our study aims to elucidate the contribution of full-length OPN (OPN-FL) plasma expression, OPN N-half, and to cognitive impairment in the PIL mice model.

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Intronic Variants in the (rs2303426 and rs10179950) and (rs2286681 and rs62456178) Genes Are Not Associated with Colorectal Cancer in Mexican Patients.

Genes (Basel)

October 2024

Doctorado en Genética Humana e Instituto de Genética Humana "Dr. Enrique Corona Rivera", Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.

Background/objectives: In the origin and development of colorectal cancer (CRC), a global public health problem, a dysfunction mismatch repair system appears to be a key factor. The objective was to determine the association of intronic variants in the and genes with CRC in Mexican patients.

Methods: Blood samples of 143 CRC patients and 146 reference individuals were genotyped through TaqMan Genotyping Assays.

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Heat domes increase vulnerability of native stingless bees by simultaneously weakening key survival traits.

Sci Total Environ

December 2024

Departamento de Apicultura Tropical, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, Mexico.

Article Synopsis
  • Heatwaves are becoming more frequent, but their nonlethal effects on tropical insects, especially stingless bees, haven't been fully studied.
  • This study is the first to look at how sublethal heat stress during development affects the size, shape, immune responses, and lifespans of different castes (workers, gynes, males) in stingless bees.
  • Results showed that heat-stressed individuals were smaller and had reduced immune responses, particularly males; heat stress also led to earlier foraging and shorter lifespans in workers, raising concerns about colony fitness and the future of stingless bee species.
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Functional brain hubs are related to age: A primer study with rs-fMRI.

Int J Clin Health Psychol

October 2024

Department of Social Psychology & Quantitative Psychology, Faculty of Psychology, University of Barcelona, Barcelona, Spain.

Background/objective: Research on the ontogenetic development of brain networks using resting state has shown to be useful for understanding age-associated changes in brain connectivity. This work aimed to analyze the relationship between brain connectivity, age and intelligence.

Methods: A sample of 26 children and adolescents between 6 and 18 years of both sexes underwent a resting-state functional magnetic resonance imaging study.

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Phytochemicals from Cactaceae family for cancer prevention and therapy.

Front Pharmacol

October 2024

Laboratorio de Neuroinmunobiología Molecular, Instituto de Investigación en Ciencias Biomédicas (IICB), Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara Mexico.

Cancer is a global health issue, increasingly prevalent and a leading cause of mortality. Despite extensive research, conventional treatments remain aggressive, often damaging healthy cells, and exhibit limited efficacy. Addressing drug resistance and enhancing treatment effectiveness are critical challenges in advancing cancer therapy.

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Phylogenomic insights into Neotropical relationships.

Heliyon

October 2024

Red de Diversidad Biológica del Occidente Mexicano, Instituto de Ecología, A.C, Avenida Lázaro Cárdenas 253, 61600, Pátzcuaro, Michoacán, Mexico.

Despite extensive research into the phylogenetic relationships of the genus , Neotropical taxa have been neglected. This is partly because their numbers have recently doubled and now account for almost half of the global richness. Therefore, by sampling one-third of all Neotropical taxa their relationships were studied using morphological, nuclear, and plastome data.

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Genome Sequences of Canine Parvovirus Type 2c Prevalent in Western Mexico.

Arch Razi Inst

April 2024

Departmento de Medicina Veterinaria, Centro Universitario de Ciencias Biológicas Y Agropecuarias, Cam. Ramón Padilla Sánchez 2100, Las Agujas, 44600 Zapopan, Jal. Universidad de Guadalajara, Zapopan, Jalisco, México.

Article Synopsis
  • * In a recent study, researchers in Mexico sequenced genomes of CPV-2c, a variant that has been circulating exclusively in the country for the last seven years, contrasting with other regions where multiple variants are found.
  • * The genomic analysis revealed a high similarity (over 99%) to global CPV-2 sequences and identified 52 nucleotide mutations, contributing to a better understanding of the virus's evolution and epidemiology in Mexico.
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Neuronal splicing regulator RNA binding protein, fox-1 homolog 3 (NeuN/RbFox3), is expressed in postmitotic neurons and distributed heterogeneously in the cell. During excitotoxicity events caused by the excess glutamate, several alterations that culminate in neuronal death have been described. However, NeuN/RbFox3 organization and distribution are still unknown.

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Multi-taxa approaches are increasingly used because they describe complementary aspects of ecosystem dynamics from a community ecology perspective. In west-central Mexico, the complex biogeography and topography have created an environment where temperate and tropical forests converge, resulting in great biological diversity. Within this region, the Sierra de Quila Natural Protected Area (SQPA) offers an important example for understanding ecological community dynamics.

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Linking intraspecies variability of Salmonella enterica isolates under acidic conditions to genotype.

J Food Sci

November 2024

Departamento de Investigación y Posgrado de Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico.

There is a lack of information about Salmonella enterica strains under acidic conditions and their association with their genome. This study characterized intraspecies variability in the growth of 167 S. enterica isolates under two acid conditions (pH 4 and 5) and linked to the whole genome sequencing (WGS) data.

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Article Synopsis
  • Extracellular vesicles (EVs) are tiny particles that transmit specific molecules between cells, playing a role in cell activation and inflammation, which are linked to various diseases.
  • The global epidemic of chronic liver disease (CLD) affects about 1.5 billion people, with cirrhosis, liver cancer, hepatitis infections, and obesity as major risk factors.
  • This text reviews the characteristics and types of EVs, emphasizing their role in liver disease related to fat accumulation (steatosis) and discussing their potential in diagnosis and treatment.
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Neuroinflammation and oxidative stress are important features in the pathogenesis and development of synucleinopathies, the glial activation and upregulation of pro-inflammatory and oxidative mediators induce alpha-synuclein (α-syn) accumulation. Recent studies have shown that bee venom (BV) has beneficial effects on symptoms of these neurodegenerative diseases. BV is known to exert anti-inflammatory and anti-oxidative effects.

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Comparative Studies for Cryopreservation of Shoot Tips by Droplet-Vitrification.

Plants (Basel)

September 2024

Facultad de Ciencias Químicas, Universidad Veracruzana, Orizaba 94340, Veracruz, Mexico.

The objective of this work was to assess the suitability of the Droplet-vitrification protocol previously developed with shoot tips for the cryopreservation of six species. Shoot tips were precultured for 1 day on a medium with 0.3 M sucrose in the dark, loaded in a solution with 1.

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New Advances in the Study of CMTM6, a Focus on Its Novel Non-Canonical Cellular Locations, and Functions beyond Its Role as a PD-L1 Stabilizer.

Cancers (Basel)

September 2024

Instituto de Investigación en Enfermedades Crónico Degenerativas, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.

CMTM6 is a membrane protein that acts as a regulator of PD-L1, maintaining its expression on the cell surface, and can prevent its lysosome-mediated degradation. It is unknown if CMTM6 is present in the plasma of patients with cervical cancer, and if it has non-canonical subcellular localizations in cell lines derived from cervical cancer. Our objective was to determine whether CMTM6 is found in plasma derived from cervical cancer patients and its subcellular localization in cell lines.

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Background: The insoluble tangles of alpha-synuclein (α-syn) protein in the nigrostriatal circuit, characteristic of synucleinopathy, originate from low molecular weight oligomers, whose appearance and dissemination are related to neuroinflammation. These oligomeric forms of α-syn are considered highly cytotoxic but transient, so knowing the timing in which they appear remains challenging. Therefore, this study aimed to analyze the abundance of oligomeric forms of α-syn and tyrosine hydroxylase (TH) between 3 and 7 days after inducing neuroinflammation with lipopolysaccharide (LPS).

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Taxonomic diversity of amphibians (Amphibia, Anura) and reptiles (Reptilia, Testudines, Squamata) in a heterogeneous landscape in west-central Mexico: a checklist and notes on geographical distributions.

Zookeys

September 2024

Laboratorio de Ecología Molecular, Microbiología y Taxonomía (LEMITAX), Departamento de Ecología Aplicada,, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Camino Ramón Padilla Sánchez 2100, CP 45200, Zapopan, Jalisco, Mexico Universidad de Guadalajara Zapopan Mexico.

In Mexico, land use changes have significantly impacted the diversity of amphibians and reptiles in a negative way. In light of this, we evaluate the alpha and beta components of the taxonomic diversity of amphibians and reptiles in a heterogeneous landscape in west-central Mexico. Additionally, we provide a checklist of amphibian and reptile species recorded over nine years of observations within the studied landscape and surrounding areas.

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Prevalence of and in bats captured in the state of Yucatan, southeastern Mexico.

One Health

December 2024

Virologia Clinica y Zoonosis, Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Hospital Universitario Reina Sofia de Cordoba, Universidad de Cordoba, Cordoba, Spain.

Article Synopsis
  • Mosquito-borne viruses, such as DENV, ZIKV, and CHIKV, pose a serious public health risk globally, but the role of bats in their transmission to humans is not well-studied.
  • Researchers captured 144 bats from various habitats in Yucatan, Mexico, and tested them for these viruses using blood samples and swabs, finding a significant prevalence of RNA genomes associated with DENV, ZIKV, and CHIKV.
  • The study revealed a higher detection rate of these viruses during the dry season, suggesting that bats may play a role in the transmission cycle of these viruses and that climatic conditions could influence viral activity patterns.
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To achieve global herd immunity, widespread vaccination is the most effective strategy. Vaccines stimulate the immune system, generating cytokines and chemokines, isotype antibodies, and neutralizing antibodies; all these molecules collectively provide a more comprehensive characterization of the immune response post-vaccination. We conducted a longitudinal study in northwestern Mexico, involving 120 individuals before vaccination and after the first dose of the SARS-CoV-2 vaccine, and 46 individuals after their second dose.

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Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). While BCG protects against TB in children, its protection against pulmonary TB in adults is suboptimal, and the development of a better TB vaccine is a global health priority. Previously, we reported two recombinant BCG strains effective against murine TB with low virulence and lung pathology in immunocompromised mice and guinea pigs.

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pathogenic variants are related to the improper functioning of the WNT/β-catenin pathway, promoting the development of different types of cancer of somatic origin. Bioinformatics analyses of genetic variation are a great tool to understand the possible consequences of these variants on protein structure and function and their probable implication in pathologies. The objective of this study is to describe the impact of the missense variants of uncertain significance (VUS) of the gene on structure and function of the β-catenin protein.

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Uncovering the Expression Pattern of the Costimulatory Receptors ICOS, 4-1BB, and OX-40 in Exhausted Peripheral and Tumor-Infiltrating Natural Killer Cells from Patients with Cervical Cancer.

Int J Mol Sci

August 2024

Instituto de Investigación en Enfermedades Crónico Degenerativas, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada # 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.

Cervical cancer (CC) poses a significant health burden, particularly in low- and middle-income countries. NK cells play a crucial role against CC; however, they can become exhausted and lose their cytotoxic capacity. This work explores the expression of costimulatory receptors (ICOS, 4-1BB, OX-40) in exhausted NK cells from CC patients.

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Furin (Fur) is a member of the protease convertase family; its expression is crucial for cleaving and maturing many proteins. Fur also represents a therapeutic target in cancer, autoimmune diseases, and viral infections. Pioglitazone (PGZ) and rosiglitazone (RGZ) are thiazolidinediones prescribed to type 2 diabetes patients and are structurally similar to the known Fur inhibitors naphthofluorescein (NPF) and pirfenidone (PFD).

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Obsessive-compulsive disorder (OCD) is a mental affliction characterized by compulsive behaviors often manifested in intrusive thoughts and repetitive actions. The quinpirole model has been used with rats to replicate compulsive behaviors and study the neurophysiological processes associated with this pathology. Several changes in the dendritic spines of the medial prefrontal cortex (mPFC) and dorsolateral striatum (DLS) have been related to the occurrence of compulsive behaviors.

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Earth harbours an extraordinary plant phenotypic diversity that is at risk from ongoing global changes. However, it remains unknown how increasing aridity and livestock grazing pressure-two major drivers of global change-shape the trait covariation that underlies plant phenotypic diversity. Here we assessed how covariation among 20 chemical and morphological traits responds to aridity and grazing pressure within global drylands.

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We searched for the prevalence of actionable somatic mutations in exon 2 of the gene in western Mexican patients with CRC. Tumor tissue DNA samples from 150 patients with sporadic CRC recruited at the Civil Hospital of Guadalajara were analyzed. Mutations in exon 2 of the gene were identified using Sanger sequencing, and the data were analyzed considering clinical-pathological characteristics.

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