443 results match your criteria: "Centro Hospitalar Tondela-Viseu.[Affiliation]"

A 55-year-old-woman was admitted to the emergency department with hematemesis and abdominal pain. Her physical examination was unremarkable. Laboratory results without anemia.

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Repeated human leukocyte antigens eplets, importance of typing the partner.

Transpl Immunol

June 2024

Nephrology Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Nephrology & Infectious Diseases R & D Group, i3S-Instituto de Investigação e Inovação em Saúde, INEB-Instituto de Engenharia Biomédica, Universidade do Porto, Portugal; Faculty of Medicine - University of Porto, Portugal.

Article Synopsis
  • Antibody-mediated rejection (AMR) is a common problem after kidney transplants and can cause the new kidney to fail.
  • A 48-year-old woman who got a new kidney after being on dialysis had early signs of AMR, even though she didn't have antibodies before the surgery.
  • Scientists found that her body's reaction was because she had previous pregnancies that created similar antibodies, and her husband’s tissue matched some parts of the donor’s kidney, causing the immune response.
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Article Synopsis
  • - The study investigates cutaneous (CL) and mucosal leishmaniasis (ML) cases in mainland Portugal from 2010 to 2020, identifying 43 CL and 7 ML cases, predominantly in immunosuppressed individuals.
  • - Most cases were autochthonous, with common symptoms including papules/nodules, particularly on the head, and a varied treatment approach noted, mainly using liposomal amphotericin B for ML.
  • - The findings highlight a need for better surveillance, clinical awareness, and diagnostic capabilities for leishmaniasis, advocating a One Health approach to tackle the complexities of the disease in Portugal and globally.
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  • - Ventilator-associated pneumonia (VAP) is a common and serious infection affecting critically ill patients on invasive mechanical ventilation, with significant negative effects on their recovery and healthcare resources in Portugal.
  • - In a study involving patients from ICUs between July 2016 and December 2017, it was found that 9.2% of those on mechanical ventilation developed VAP, with similar mortality rates for both VAP and non-VAP patients at various time points.
  • - Those with VAP experienced notably longer stays in the ICU and hospital, as well as extended time on ventilation, and inappropriate antimicrobial treatments increased the 28-day mortality rate among these patients.
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  • The study aimed to compare proliferative (PLN) and membranous (MLN) lupus nephritis (LN) in terms of clinical presentation and long-term health outcomes, focusing on predictors for chronic kidney disease (CKD).
  • A multicenter observational approach involved analyzing data from 260 patients with biopsy-confirmed PLN, MLN, and mixed LN, and used Cox regression to identify CKD predictors over an average follow-up of 8 years.
  • Results indicated that MLN patients generally had better kidney function, with lower serum creatinine and more normalized complement levels, while an estimated glomerular filtration rate (eGFR) of 75 mL/min/1.73 m2 after one year was the strongest
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Introduction: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer.

Methods: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease.

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The development of vaccinations has been game-changing in the ongoing effort to combat the COVID-19 pandemic. Until now, adverse effects are being reported at low frequency, including thrombocytopenia and myocarditis. Careful monitoring for any suspicious symptoms and signs following vaccination is necessary.

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Screening of refugees from Ukraine for TB: a TBnet survey.

Int J Tuberc Lung Dis

April 2024

EPI Unit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal;, Unidade de Investigação Clínica da Administracao Regional de Saúde do Norte, Porto, Departamento de Estudos das Populações, Instituto de Ciências Biomédicas Abel Salazar, Porto, Instituto de Saúde Pública Doutor Ricardo Jorge - INSA, Porto, Portugal.

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The Epstein-Barr virus (EBV) is a DNA virus that has been infecting humans since ancient times, capable of causing a wide range of pathologies and affecting approximately 90% of the population. A 61-year-old male with no significant medical history presented with a 5-day history of imbalance and difficulty walking. Neurological examination revealed specific findings, including absent reflexes, bilateral asynergy, and gait abnormalities.

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Anorexia nervosa (AN) belongs to the spectrum of food disorders and affects approximately 2.9 million people worldwide. It is responsible for numerous and serious medical complications.

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Neonatal jaundice is a frequently observed occurrence in full-term newborns and typically manifests between 48 and 96 hours following birth. Early-onset jaundice is primarily induced by pathological factors, namely sepsis, hemolysis and an excessive accumulation of bilirubin resulting from the breakdown of red blood cells.We present a case involving a full-term newborn with an uneventful perinatal history, who exhibited jaundice within the initial day of life and was subsequently admitted to the neonatal intensive care unit to commence intensive phototherapy.

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Article Synopsis
  • Childhood emotional disorders (EDs) like anxiety and depression are a growing public health issue, necessitating early and effective treatment for children aged 7 to 12 years.
  • The clinical trial will evaluate a blended treatment program named "Emotion Detectives In-Out," which combines face-to-face and online therapy, against the established Coping Cat program for effectiveness.
  • The blended format is anticipated to increase accessibility for families, addressing barriers such as parents' limited time for attending regular sessions.
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Predictors of myositis in systemic sclerosis.

Rheumatology (Oxford)

September 2024

Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, CAML, Lisboa, Portugal.

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Introduction: is the most commonly isolated pathogen in bronchiectasis and is associated with worse outcomes. Eradication treatment is recommended by guidelines, but the evidence base is limited. The expected success rate of eradication in clinical practice is not known.

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Pica indicates the persistent ingestion of inedible substances over a period of at least 1 month, being discordant to the individual's cognitive development level and not directly attributable to cultural or social normative practices. The literature suggests that the prevalence of pica varies significantly according to the social and clinical context. It can co-occur with psychiatric disorders, with its etiology being poorly understood and most likely multifactorial.

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Spontaneous intracranial hypotension is a condition resulting from cerebrospinal fluid leaks at the spinal level that disrupt the regulation of intracranial pressure. This disorder is an uncommon cause of debilitating headaches but can have variable clinical manifestations, which contributes to delayed diagnosis and potentially severe consequences. The standard treatment consists of conservative measures such as bed rest, hydration, and a pharmacological approach with paracetamol, caffeine, ergotamine, and dexamethasone.

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Idiopathic systemic capillary leak syndrome (ISCLS) is a rare condition caused by the extravasation of intravascular fluids and proteins into the interstitial space due to increased vascular endothelium permeability. It is characterized by episodes of hypotension, hypoalbuminemia, and hemoconcentration with generalized edema. Its etiopathogenesis is unknown.

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Introduction: Immune-mediated necrotizing myopathy (IMNM) is characterized by acute or subacute, severe proximal muscle weakness and myofiber necrosis with minimal inflammatory cell infiltrate observed on muscle biopsy. On the other hand, sarcoidosis is characterised by the presence of non-caseating granulomas that can develop in several organs.

Case Report: We present the unique case of a 49-year-old woman, with no previous medical history, who had a rare concomitant occurrence of IMNM and pulmonary sarcoidosis.

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Meningoencephalocele is a rare congenital midline defect of cranial bone fusion characterized by herniation of the brain and meninges through the skull. In addition to the challenges of managing a major neurosurgical procedure in a pediatric patient, airway management in this group of patients requires advanced skills, and a difficult airway should be anticipated from the start. Since awake intubation is not an option in most pediatric cases with airway anatomy abnormalities and maintaining an adequate seal with a pediatric face mask is often impossible, airway management in patients with these lesions is highly challenging.

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