294 results match your criteria: "Centre psychotherapique de Nancy[Affiliation]"

Objectives: The aim of this study was to translate the Stigma Resistance Scale into French and to examine its psychometric qualities to measure stigma resistance in people with psychotic disorders.

Methods: The Stigma Resistance Scale was rigorously translated into French, involving translation, back-translation, and adjustments based on focus groups. The French version of the Stigma Resistance Scale comprises 20 items divided into five subscales measuring resistance to stigma at different levels.

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Background: Quality of life is decreased in bipolar disorders (BD) and contributes to poor prognosis. However, little is known about the causal pathways that may affect it. This study aimed to explore health-related QoL (HRQoL) in BD and investigate its relationship with cognition and psychosocial functioning.

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Refining Criteria for a Neurodevelopmental Subphenotype of Bipolar Disorders: A FondaMental Advanced Centers of Expertise for Bipolar Disorders Study.

Biol Psychiatry

October 2024

Fondation Fondamental, Créteil, France; Centre Hospitalier Universitaire de Montpellier, Hôpital Lapeyronie, Psychiatric Emergency and Post Emergency Department, Pole Urgence, Montpellier, France; L'Institut de Génomique Fonctionnelle, Université de Montpellier, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Montpellier, France. Electronic address:

Article Synopsis
  • Bipolar disorder (BD) is a complex mental health condition, and researchers aimed to identify a neurodevelopmental phenotype (NDP) that contributes to its development and impacts clinical outcomes.
  • By analyzing data from over 4,400 BD patients, they established nine specific clinical features that characterize this NDP, which are linked to poorer prognosis and treatment responses.
  • The findings suggest that patients with a higher NDP load may have overlapping genetic factors with ADHD, indicating a potential shared biological basis for these disorders.
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Diet quality and associations with lactate and metabolic syndrome in bipolar disorder.

J Affect Disord

November 2024

Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Mitochondrial Innovation Initiative, MITO2i, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

Background: Nutrition is largely affected in bipolar disorder (BD), however, there is a lack of understanding on the relationship between dietary categories, BD, and the prevalence of metabolic syndrome. The objective of this study is to examine dietary trends in BD and it is hypothesized that diets with increased consumption of seafood and high-fiber carbohydrates will be correlated to improved patient outcomes, and a lower frequency of metabolic syndrome.

Methods: This retrospective cohort study includes two French cohorts.

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ElectroRetinoGraphy toward an exploration of the therapeutic potential of antidepressants in patients with major depressive disorder: A scoping review of the literature.

Neurosci Biobehav Rev

September 2024

Pôle Hospitalo-Universitaire de Psychiatrie d'Adulte et d'Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, 1, rue du Docteur Archambault, Laxou 54 520, France. Electronic address:

Major Depressive Disorder (MDD) is characterized by at least one major depressive episode. It requires medical attention typically involving the prescription of antidepressants. Remission in MDD patients is often difficult to achieve because of the limited effectiveness of these drugs.

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Article Synopsis
  • Individuals with bipolar disorders (BD) tend to have a shorter life expectancy, prompting the need for easily measurable markers of accelerated aging like BioAge, calculated from routine blood tests and physical exams.
  • In a study of 2,220 outpatients with BD, results showed that a small percentage had significant BioAge Acceleration, which is linked to factors such as young age, male sex, being overweight, and sleep issues.
  • Further research is needed to confirm these findings with different groups and explore whether improving factors like metabolic health and sleep could impact aging rates in individuals with BD.
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Insights into Postictal Psychosis, from functional imaging and EEG: A systematic review.

Seizure

October 2024

EEG-monitoring Unit, Neurology Department, Hôpital Central, CHU de Nancy, 54000 Nancy, France; Pôle Universitaire du Grand Nancy, Centre Psychothérapique de Nancy, 54000 Laxou, France.. Electronic address:

Multiple hypotheses exist about the pathophysiology of Postictal Psychosis (PIP). As the clinical manifestations of PIP are roughly stereotyped, we assumed the existence of a common neurological pathway. This study aimed to determine if a specific brain network sustained the psychotic episode, regardless of the localization of the epileptogenic zone.

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Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder.

Psychiatry Res

September 2024

Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Mitochondrial Innovation Initiative, MITO2i, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Article Synopsis
  • This study investigates the link between mitochondrial blood biomarkers, specifically lactate and circulating cell-free mitochondrial DNA, and markers of metabolic syndrome in bipolar disorder patients, hypothesizing that lactate levels would be higher in those with metabolic syndrome.
  • The research involved a large cohort of 837 stable bipolar disorder patients and 237 others for validation, revealing that higher lactate levels correlated significantly with factors like triglycerides and blood pressure, indicating a strong association with metabolic syndrome.
  • The findings suggest that while lactate is a key biomarker related to metabolic syndrome in bipolar patients, circulating mitochondrial DNA levels do not show this same correlation, highlighting the potential for personalized treatment strategies based on these metabolite profiles.
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Development and validation of the DBS-PS (Deep Brain Stimulation-Perception Scale): Assessing parkinsonian patients' expectations to prevent post-operative disappointment?

J Neurol Sci

July 2024

Université de Lille, INSERM, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, LICEND, NS-PARK/FCRIN Network, Lille, France; CHU Lille, Neurology and Movement Disorders Department, Reference Center for Parkinson's Disease, NS-PARK/FCRIN Network, Lille, France.

Article Synopsis
  • Recent studies indicate that understanding the preoperative expectations of Parkinson's disease patients undergoing deep brain stimulation (DBS) can enhance treatment outcomes, but there are limited validated tools to measure these expectations.
  • The DBS-PS (Deep Brain Stimulation - Perception Scale) was developed as an 11-item self-administered questionnaire, divided into three domains: expectations for PD, social-life and leisure, and intimate life, and validated through exploratory factor analysis and item response theory.
  • The study showed that the DBS-PS has good reliability and validity, making it a practical tool for assessing patient expectations in clinical practice, which may help in cognitive restructuring before surgery.
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Anticipatory anxiety of seizures: What is the best treatment?

Epilepsy Behav Rep

May 2024

EEG-monitoring Unit, Neurology Department, Hôpital Central, CHU de Nancy, 54000 Nancy, France.

Anxiety disorders affect roughly 25% of people with epilepsy (PWE), and are associated with a strong impairment of quality of life and a poorer stabilization of epilepsy. Anticipatory anxiety of seizure (AAS), defined by the persistent worry or fear to have another seizure, is highly frequent and associated with avoidant behavior. Unfortunately, AAS is often overlooked and untreated.

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Post-epileptic seizure posttraumatic stress Disorder: A mediation analysis.

Epilepsy Behav

August 2024

CHRU de Nancy, Département de Neurologie, Nancy, France; Pôle Hospitalo-Universitaire de Psychiatrie D'Adultes Du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France. Electronic address:

Objective: Previous studies investigated the varying prevalence of post-epileptic seizure posttraumatic stress disorder (PS-PTSD). The current study aimed first to compare the profiles of patients with and without PS-PTSD and, second, to study the interaction between other past traumatic experiences, subjective ictal anxiety, psychiatric comorbidities, and PS-PTSD in people with epilepsy (PWE).

Methods: We conducted an observational study, investigating past traumatic experiences and PS-PTSD through standardized scales (CTQ-28, LEC-5 and PCL-5).

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A cross-sectional survey on French psychiatrists' knowledge and perceptions of dissociative identity disorder.

Encephale

May 2024

Pôle hospitalo-universitaire de psychiatrie d'adultes du Grand-Nancy, centre psychothérapique de Nancy, Laxou, France; Faculté de médecine, université de Lorraine, Vandœuvre-Lès-Nancy, France; Centre du psychotraumatisme de Lorraine-Sud (CPN), Nancy, France; Département de neurologie, CHRU de Nancy, Nancy, France. Electronic address:

Objective: The aim of this study was to determine French psychiatrists' level of general knowledge about dissociative identity disorder and to evaluate their perceptions of this condition.

Methods: In this study, French psychiatrists were invited by e-mail to answer an online survey. The questionnaire asked about their general knowledge and perceptions of dissociative identity disorder.

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Objective: Less is known concerning the evolution of coping strategies before and after deep brain stimulation (DBS) in Parkinson's disease (PD) patients.

Methods: In a randomized controlled trial, coping was measured with the neurological version of the CHIP (Coping with Health Injuries and Problem) and the BriefCOPE in PD patients before ( T1: DBS - 2 months) and after (T2: + 3 months, T3: + 6 months) DBS. Patients (N = 50, age 59 ± 5.

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Background: The care environment significantly influences the experiences of patients with severe mental illness and the quality of their care. While a welcoming and stimulating environment enhances patient satisfaction and health outcomes, psychiatric facilities often prioritize staff workflow over patient needs. Addressing these challenges is crucial to improving patient experiences and outcomes in mental health care.

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Defining homogeneous subgroups of bipolar disorder (BD) is a major goal in personalized psychiatry and research. According to the neurodevelopmental theory, age at onset may be a key variable. As potential trait markers of neurodevelopment, cognitive and functional impairment should be greater in the early form of the disease, particularly type 1 BD (BD I).

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Background And Aims: Pre-clinical studies suggest that the simultaneous blockade of the α1b and 5HT2A receptors may be effective in reducing alcohol consumption. This study aimed to assess the efficacy and safety of prazosin (α1b blocker) and cyproheptadine (5HT2A blocker) combination in decreasing total alcohol consumption (TAC) in alcohol use disorder (AUD).

Design, Setting And Participants: This was a double-blind, parallel group, placebo-controlled, Phase 2, randomized clinical trial conducted in 32 addiction treatment centres in France.

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Differential associations between insight and quality-of-life dimensions among individuals with schizophrenia.

Rehabil Psychol

May 2024

Centre Ressource de Rehabilitation Psychosociale et de Remediation Cognitive, Hopital Le Vinatier, Centre National de la Recherche Scientifique, Universite de Lyon.

Purpose/objective: In schizophrenia, insight, the recognition that one has a medical illness that requires treatment, has long been related to deteriorated quality of life. Yet, insight and quality of life are broad constructs that encompass several dimensions. Here, we investigated differential associations between insight and quality-of-life dimensions using a psychological network approach.

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Addiction medicine is a dynamic field that encompasses clinical practice and research in the context of societal, economic, and cultural factors at the local, national, regional, and global levels. This field has evolved profoundly during the past decades in terms of scopes and activities with the contribution of addiction medicine scientists and professionals globally. The dynamic nature of drug addiction at the global level has resulted in a crucial need for developing an international collaborative network of addiction societies, treatment programs and experts to monitor emerging national, regional, and global concerns.

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Factors associated with lamotrigine concentration/dose ratio in individuals with bipolar disorders.

Eur Neuropsychopharmacol

August 2023

Université Paris Cité Inserm UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, 75006, Paris, France; Fondation FondaMental, 94010, Créteil, France; Centres Experts Trouble Bipolaire et Dépression Résistante, Assistance Publique des Hôpitaux de Paris, Hôpital Lariboisière-Fernand Widal, 75010 Paris, France.

Monitoring of lamotrigine levels is recommended in epilepsy. However, in bipolar disorders (BD), no study has described the therapeutic range in daily practice and factors being associated to it. We used retrospective data of individuals with BD, treated with lamotrigine, and included in the FondaMental Advanced Centers of Expertise for Bipolar Disorders cohort.

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[From nursing to changing social representations: the study of health literacy in psychiatry].

Soins

March 2024

Service de psychiatrie de l'enfant et de l'adolescent, centre psychothérapique de Nancy, Laxou, hôpital d'enfants, centre hospitalier régional universitaire de Nancy, rue du Morvan, 54505 Vandœuvre-lès-Nancy cedex, France; Institut européen du thermalisme, faculté de médecine, maïeutique et métiers de la santé à Nancy, campus Biologie-Santé, 9 avenue de la Forêt de Haye, BP 20199, 54505 Vandœuvre-lès-Nancy Cedex, France.

The Litterapsy study focuses on the assessment of health literacy in patients with psychiatric disorders, a field that has been little studied in France. It is based on the observations of an advanced practice nurse specializing in psychosocial rehabilitation. Its aim is to provide objective data to better understand how these patients understand medical information and navigate the healthcare system.

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Article Synopsis
  • Bipolar disorder is linked to premature cellular aging, evidenced by shortened telomere length (TL), particularly in a subgroup of young individuals.
  • A study analyzed 542 individuals with bipolar disorder, finding a cluster of young people (average age 29.64) with significantly shorter TL.
  • Gene expression analysis revealed decreased levels of the gene POT1 in this subgroup, indicating a potential new mechanism related to telomere shortening in bipolar disorder.
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Article Synopsis
  • Lithium is the primary treatment for bipolar disorder (BD), but how it works and predicts outcomes is not fully understood.
  • A previous study identified key cellular pathways linked to lithium response, including focal adhesion and PI3K-Akt signaling.
  • In this new study, researchers confirmed these pathways in a larger group of 2039 patients but found no connection with the extracellular matrix, suggesting that issues with neuronal growth signaling may impact lithium effectiveness.
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Introduction: Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%.

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