3 results match your criteria: "Centre of Excellence CENDO[Affiliation]"
Heart ventricles specific stress-induced changes in β-adrenoceptors and muscarinic receptors.
Gen Physiol Biophys
September 2014
Institute of Experimental Endocrinology, Centre of Excellence CENDO, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovak Republic.
Article Synopsis
- The study investigates how acute and repeated stress affects catecholamine levels, gene expression, and receptor proteins in the right ventricle of rats, comparing these effects to previously observed changes in the left ventricle.
- In the right ventricles, levels of noradrenaline and adrenaline increased, but there were no significant changes in β1-AR receptors, while β2-AR gene expression significantly decreased and β3-AR expression increased after repeated stress.
- The findings highlight the importance of receptor balance between the left and right ventricles in maintaining heart stability under stress, suggesting that decreased β2-AR may play a crucial role in heart physiology.
Repeated stress down-regulates β(2)- and α (2C)-adrenergic receptors and up-regulates gene expression of IL-6 in the rat spleen.
Cell Mol Neurobiol
October 2010
Institute of Experimental Endocrinology, Centre of Excellence CENDO, Slovak Academy of Sciences, Vlarska 3, Bratislava, Slovakia.
Catecholamines are among first compounds released during stress, and they regulate many functions of the organism, including immune system, via adrenergic receptors (ARs). Spleen, as an immune organ with high number of macrophages, possesses various ARs, from which β(2)-ARs are considered to be the most important for the modulation of immune functions. Nevertheless, little is known about the regulation and involvement of ARs in the splenic function by stress.
View Article and Find Full Text PDFRegulation of gene expression of catecholamine biosynthetic enzymes in dopamine-beta-hydroxylase- and CRH-knockout mice exposed to stress.
Ann N Y Acad Sci
December 2008
Institute of Experimental Endocrinology, Centre of Excellence CENDO, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Norepinephrine-deficient mice harbor a disruption of the gene for dopamine-beta-hydroxylase (DBH-KO). Corticotropin-releasing hormone knockout mice (CRH-KO) have markedly reduced HPA activity. The aim of the present work was to study how deficiency of DBH and CRH would affect tyrosine hydroxylase (TH), DBH, and phenylethanolamine N-methyltransferase (PNMT) gene expression and protein levels in the adrenal medulla (AM) and stellate ganglia (SG) of control and stressed mice.
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