4 results match your criteria: "Centre of Brain Science[Affiliation]"
Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells.
Nat Cell Biol
October 2022
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation.
Glioblastoma (GBM) is characterized by exceptionally high intratumoral heterogeneity. However, the molecular mechanisms underlying the origin of different GBM cell populations remain unclear. Here, we found that the compositions of ribosomes of GBM cells in the tumour core and edge differ due to alternative RNA splicing.
View Article and Find Full Text PDFData on peptidyl platform-based anticancer drug synthesis and triton-x-based micellar clusters (MCs) self-assembly peculiarities for enhanced solubilization, encapsulation of hydrophobic compounds and their interaction with HeLa cells.
Data Brief
August 2019
Centre of Brain Science, Laboratory for Cell Function and Dynamics, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
The data presented here refer to a research article entitled "Self-Assembled Micellar Clusters Based on Triton-X-family Surfactants for Enhanced Solubilization, Encapsulation, Proteins Permeability Control, and Anticancer Drug Delivery" Solomonov et al., 2019. The present article provides the General Procedure for clusterization of Triton-X-based micelles and the effect of (i) metal ion, surfactant, and chelator concentration on the developed clusters formation, (ii) surfactant-chelator relation change, (iii) metal ion-micelles concertation ratio variation, (iv) metal ion replacement, (v) solvent replacement, (vi) kinetics of clusters formation, (vii) hydrophobic fluorescent dye (Coumarin 6) solubilization in aqueous MCs media, (viii) novel anticancer peptidyl drug synthesis and characterization and (ix) the viability of HeLa cells with and without the presence of drug-free Triton-X-based family MCs.
View Article and Find Full Text PDFA Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.
Dev Cell
November 2018
Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Bailrigg, Furness Building, Lancaster LA1 4YG, UK. Electronic address:
Article Synopsis
- Cilia and the cell cycle are closely connected; centrioles in the cilia base help organize cell division while also responding to signals to regulate cilia presence.
- A new fluorescent biosensor allows researchers to observe the timing of cilia assembly/disassembly and cell cycle stages in real time, providing insights at the single-cell level.
- The study finds that cilia often remain present during critical phases of the cell cycle (G1/S transition and S/G2/M-phase), highlighting their potential ongoing role in various biological processes and conditions.
Culture shapes empathic responses to physical and social pain.
Emotion
August 2016
Department of Psychology, Centre of Brain Science, University of Essex.
The present research investigates the extent to which cultural background moderates empathy in response to observing someone undergoing physical or social pain. In 3 studies, we demonstrate that East Asian and White British participants differ in both affective and cognitive components of their empathic reactions in response to someone else's pain. Compared with East Asian participants, British participants report greater empathic concern and show lower empathic accuracy.
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