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Centre national de référence du virus... Publications | LitMetric

156 results match your criteria: "Centre national de référence du virus de l'hépatite E[Affiliation]"

[Not Available].

CMAJ

November 2024

Canadian Center for Vaccinology (Abu-Raya, Langley), Dalhousie University, IWK Health Centre et Nova Scotia Health Authority; Départements de pédiatrie (Abu-Raya, Langley), de microbiologie et d'immunologie (Abu-Raya), et de santé communautaire et épidémiologie (Langley), Dalhousie University, Halifax, N.-É.; Département de pédiatrie (Lavoie), University of British Columbia, Vancouver, C.-B.

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[Not Available].

CMAJ

November 2024

Canadian Center for Vaccinology (Abu-Raya, Langley), Dalhousie University, IWK Health Centre et le Nova Scotia Health Authority; Départements de pédiatrie (Abu-Raya, Langley), de microbiologie et immunologie (Abu-Raya), et de santé communautaire et épidémiologie (Langley), Dalhousie University, Halifax, N.-É.; Département de pédiatrie (Lavoie), University of British Columbia, Vancouver, C.-B.

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Changes to virus taxonomy and the ICTV Statutes ratified by the International Committee on Taxonomy of Viruses (2024).

Arch Virol

November 2024

The Biodesign Center for Fundamental and Applied Microbiomics, School of Life Sciences, Center for Evolution and Medicine, Arizona State University, Tempe, AZ, 85287-4701, USA.

Article Synopsis
  • The article outlines recent updates to virus taxonomy approved by the International Committee on Taxonomy of Viruses (ICTV) in April 2024.
  • The ICTV invited members to vote on 203 taxonomic proposals, resulting in significant additions across various levels, including one new phylum and 3,547 new species.
  • The total number of established virus species now stands at 14,690, following the ratification of proposals for species name formatting to the binomial system.
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Genomic surveillance as a scalable framework for precision phage therapy against antibiotic-resistant pathogens.

Cell

October 2024

Synthetic and Systems Biology Unit, Institute of Biochemistry, National Laboratory of Biotechnology, HUN-REN Biological Research Centre, Temesvári Krt. 62, 6726 Szeged, Hungary; HCEMM-BRC Translational Microbiology Research Group, Budapesti út 9, 6728 Szeged, Hungary. Electronic address:

Article Synopsis
  • Phage therapy is a new way to fight germs that are super tough against antibiotics, especially in hospitals.
  • Scientists are figuring out how to create special mixes of viruses called phages that can target specific strains of a dangerous germ called Acinetobacter baumannii.
  • By studying where these germs are found in the world, researchers can prepare special phage treatments for different regions, which has been shown to work well in tests and with animals.
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Spleen stiffness measurement by vibration-controlled transient elastography at 100 Hz for non-invasive predicted diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a modelling study.

Lancet Gastroenterol Hepatol

December 2024

Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria; Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria; Department of Medicine III and Clinical Research Group Mechanisms in Portal Hypertension, Medical University of Vienna, Vienna, Austria. Electronic address:

Article Synopsis
  • Researchers aimed to evaluate spleen stiffness measurement (SSM) as a standalone non-invasive test for clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease (cACLD) and compare it to the existing ANTICIPATE±NASH model.
  • The study involved 407 patients recruited from 16 expert centers in Europe, utilizing various non-invasive tests alongside hepatic venous pressure gradient measurements to assess CSPH probability.
  • The findings indicated the potential for SSM to enhance diagnostic capabilities, as models were created to evaluate its effectiveness and discriminative ability compared to existing methods using binary logistic regression analysis.
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Mosquito management strategies in European rice fields: Environmental and public health perspectives.

J Environ Manage

November 2024

Estación Biológica de Doñana, CSIC. Avda, Américo Vespucio s/n, 41092, Sevilla, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain. Electronic address:

Rice is a crucial food source and an important economic activity globally. Rice fields provide habitats for birds and other organisms but also serve as ideal breeding grounds for mosquitoes, including potential vectors such as Culex, Aedes, and Anopheles. There is an urgent need to manage mosquitoes associated with rice crops, as they are important pests and vectors of diverse pathogens.

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Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).

Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021.

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Developing community resilience in the face of COVID-19: case study from the Estrie region, Canada.

Health Promot Int

August 2024

Observatoire Estrien du Développement des Communautés, 1820 Rue Galt O, Sherbrooke, Quebec, J1K 1H8, Canada.

The COVID-19 pandemic undeniably impacted population health and several aspects of community organization, including service delivery and social cohesion. Intersectoral collaboration and equity, two key dimensions of community resilience, proved central to an effective and equitable response to the pandemic. Yet the factors that enabled or constrained communities' capacity to enact intersectoral collaboration and equity-focused action in such times of urgency and uncertainty remain poorly understood.

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Nirsevimab and Hospitalization for RSV Bronchiolitis.

N Engl J Med

July 2024

From the Department of General Pediatrics, Pediatric Infectious Disease, and Internal Medicine (Z.A., A.G., N.O.), Centre d'Investigations Cliniques, INSERM Unité 1426 (Z.V.), the Pediatric Intensive Care Unit (M. Levy, P.S.), the Pediatric Emergency Department (L.L.), the Department of Microbiology (M.G.-M.), the Neonatal Intensive Care Unit (V.B.), and the Unit of Clinical Epidemiology, INSERM Unité 1123 and Epidémiologie Clinique du Centre d'Investigation Clinique 1426 (K.D., O.A.), Robert-Debré University Hospital, Paris Cité University (Z.A., C.S., A.G., Z.V., M.B., J.F.C., J.T., M.L., P.S., L.L., M.G.-M., V.B., K.D., O.A.), the Departments of General Pediatrics (A.-S.R., M. Lorrot, C.F.) and Pediatric Pulmonology (A.-S.R., M. Lorrot), Armand Trousseau University Hospital, Sorbonne University (A.-S.R., M. Lorrot), the Pediatric Emergency Department (C.S.), the Pediatric Intensive Care Unit (M.B.), and the Department of General Pediatrics and Pediatric Infectious Diseases (C.S., J.F.C., J.T.), Necker-Enfants Malades University Hospital, Saint-Antoine Research Center, INSERM Unité Mixte de Recherche (UMR) S938 (H.C., B.P.), and Assistance Publique-Hôpitaux de Paris (AP-HP), Infection, Antimicrobials, Modeling, and Evolution (IAME) Research Unit, INSERM UMR 1137 (Z.A., L.L., M.G.-M., N.O.), Épidémiologie Clinique et Évaluation Économique Appliqué aux Populations Vulnérables, INSERM UMR 1123 (C.A.), the Center of Research in Epidemiology and Statistics, INSERM UMR 1153 (J.F.C.), and Biodiversity and Epidemiology of Bacterial Pathogens Research Unit, Institut Pasteur (J.T.), Paris Cité University, Paris, Groupe de Pathologie Infectieuse Pédiatrique, Nice (Z.A., M. Lorrot, R.C., C.L., N.O.), the Pediatric Emergency Department (C.A.) and the Department of General Pediatrics (L.P., C.F.D.), Jean Verdier University Hospital, AP-HP de Paris, Bondy, the Department of General Pediatrics, Centre Hospitalier Intercommunal de Créteil (M.S., C.J.), Association Clinique et Thérapeutique Infantile du Val-de-Marne France (R.C., C.L.), Institut Mondor de Recherche Biomédicale-Groupe de Recherche Clinique Groupe d'Étude des Maladies Infectieuses Néonatales et Infantiles, Université Paris Est (R.C., C.L., C.J.), and the Clinical Research Center (M.M.E.H., C.J.) and the Neonatal Intensive Care Unit (X.D.), Centre Hospitalier Intercommunal de Créteil, Université Paris Est Créteil, Faculté de Santé de Créteil, Créteil, Association Française de Pédiatrie Ambulatoire, Orleans (R.C., C.L.), and the Departments of Pediatric Pulmonology and Allergology (G.L., N.C.) and General Pediatrics (B.H., O.M., C.B.), Children's Hospital, Toulouse University Hospital, Toulouse - all in France; and the Department of Pediatrics, Department Woman-Mother-Child, Lausanne University Hospital, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (F.A.).

Article Synopsis
  • RSV is a major cause of bronchiolitis, leading to 3 million hospitalizations each year, and nirsevimab is a monoclonal antibody aimed at preventing severe RSV cases in infants.
  • A study compared infants hospitalized for RSV bronchiolitis with those visiting for unrelated reasons, assessing nirsevimab’s effectiveness in preventing hospitalizations in those under 12 months old.
  • Findings showed nirsevimab reduced hospitalization rates for RSV-associated bronchiolitis by 83% and critical care needs by about 70%, indicating it is an effective treatment option for vulnerable infants.
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Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries.

Heart Lung

October 2024

Division of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Article Synopsis
  • A study was conducted to compare stroke incidences and mortality rates in critically ill COVID-19 patients from low-and middle-income countries (LMICs) and high-income countries (HICs).
  • The results showed that stroke incidence was significantly higher in LMICs (35.7 per 1000 admitted-days) compared to HICs (17.6 per 1000 admitted-days), with patients from LMICs also facing higher mortality rates (43.6% vs. 29.2%).
  • The findings highlight the need for better stroke diagnosis and healthcare resource allocation in LMICs, as both higher income status and the presence of stroke are associated with increased risk of death
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Preclinical in vivo assessment of the activity of AZD7442 anti-SARS-CoV-2 monoclonal antibodies against Omicron sublineages.

Biomed Pharmacother

August 2024

Unité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France. Electronic address:

Article Synopsis
  • Therapeutic monoclonal antibodies have been effective against SARS-CoV-2 in at-risk groups, but their effectiveness is declining due to new variants.
  • Health authorities are using in vitro tests to guide treatment recommendations, but these tests may not accurately reflect clinical efficacy in real-world situations.
  • A study using hamsters shows that while AZD7442 retains some effectiveness against specific variants like BA.1 and BA.2, its reliability drops significantly against BA.5, underscoring the need for animal studies to enhance understanding of antibody performance in humans.
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Objectives: To investigate the frequency and factors associated with disease flare following vaccination against SARS-CoV-2 in people with inflammatory/autoimmune rheumatic and musculoskeletal diseases (I-RMDs).

Methods: Data from the European Alliance of Associations for Rheumatology Coronavirus Vaccine physician-reported registry were used. Factors associated with flare in patients with I-RMDs were investigated using multivariable logistic regression adjusted for demographic and clinical factors.

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The SARS-CoV-2 genome occupies a unique place in infection biology - it is the most highly sequenced genome on earth (making up over 20% of public sequencing datasets) with fine scale information on sampling date and geography, and has been subject to unprecedented intense analysis. As a result, these phylogenetic data are an incredibly valuable resource for science and public health. However, the vast majority of the data was sequenced by tiling amplicons across the full genome, with amplicon schemes that changed over the pandemic as mutations in the viral genome interacted with primer binding sites.

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Development and field evaluation in African and Asian countries of an hepatitis B virus PCR on open polyvalent platforms to determine treatment eligibility: results from the "Agence Nationale de Recherche sur le Sida et les hépatites" 12327 study.

Clin Microbiol Infect

August 2024

Pathogenesis and Control of Chronic and Emerging Infections, Université de Montpellier, INSERM, EFS, Université des Antilles, Montpellier, France; Department of Virology, CHU de Montpellier, Montpellier, France. Electronic address:

Objectives: Widespread testing and treatment are essential to eliminate hepatitis B virus (HBV) infection as a public health concern. However, in resource-limited countries, access to HBV PCR is limited. In this study, we developed a quantitative HBV PCR assay on open molecular platforms and evaluate its performance in diagnosing clinically significant HBV DNA thresholds as defined by the WHO (2000 IU/mL, 20 000 IU/mL, and 200 000 IU/mL).

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Article Synopsis
  • Insecticide resistance in mosquitoes is increasing globally, posing a significant challenge for vector control due to various complex mechanisms that complicate detection and monitoring methods.* -
  • This study investigates the use of MALDI-TOF Mass Spectrometry to analyze protein signatures in the legs and thoraxes of different mosquito lines to determine their susceptibility to pyrethroid insecticides.* -
  • Findings revealed distinct protein profiles between resistant and susceptible mosquito lines, with a specific protein peak associated with resistance, indicating potential for effective routine monitoring in the future.*
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High pathogenic avian influenza A(H5) viruses of clade 2.3.4.4b in Europe-Why trends of virus evolution are more difficult to predict.

Virus Evol

April 2024

European Reference Laboratory (EURL) for Avian Influenza and Newcastle Disease, Istituto Zooprofilattico Sperimentale delle Venezie, viale dell'universita 10, Legnaro, Padua 35020, Italy.

Since 2016, A(H5Nx) high pathogenic avian influenza (HPAI) virus of clade 2.3.4.

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Article Synopsis
  • Nucleic acid-amplification testing (NAT) is a method used to check blood donations for harmful viruses to keep people safe.
  • In 2019, a global survey showed that countries mostly followed government rules for testing blood for viruses like HIV and hepatitis.
  • The results indicated a trend towards using individual samples for testing instead of larger pools to improve safety in blood donations.
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Article Synopsis
  • The project reviewed the global use of nucleic acid amplification testing (NAT) in blood services to detect viral and parasite nucleic acids and reduce transfusion-related infections.
  • A survey conducted among members of the International Society of Blood Transfusion revealed a significant increase in NAT adoption over the past decade, with data showing low but notable positivity rates for various viruses in blood donations.
  • While NAT has enhanced blood transfusion safety worldwide, there is a call to address economic barriers that prevent some regions from implementing these important testing methods.
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Article Synopsis
  • One-third of COVID-19 patients deteriorate after emergency department admission, necessitating effective prognosis assessments to predict worsening conditions.
  • Current predictive biomarkers include lymphopenia and the PaO2/FiO2 ratio, while markers like immature granulocytes and monocyte differentiation did not show predictive value.
  • A combined score using decreased P/F ratio, lymphopenia, and loss of mHLA-DR proved effective in predicting patient outcomes, pointing to the importance of early immunosuppression monitoring in COVID-19 cases.
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Pseudomonasaeruginosa antimicrobial susceptibility profiles, resistance mechanisms and international clonal lineages: update from ESGARS-ESCMID/ISARPAE Group.

Clin Microbiol Infect

April 2024

Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Besançon, Besançon, France; Laboratoire associé du Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Universitaire de Besançon, Besançon, France; Chrono-environnement UMR 6249, CNRS, Université Franche-Comté, Besançon, France.

Scope: Pseudomonas aeruginosa, a ubiquitous opportunistic pathogen considered one of the paradigms of antimicrobial resistance, is among the main causes of hospital-acquired and chronic infections associated with significant morbidity and mortality. This growing threat results from the extraordinary capacity of P. aeruginosa to develop antimicrobial resistance through chromosomal mutations, the increasing prevalence of transferable resistance determinants (such as the carbapenemases and the extended-spectrum β-lactamases), and the global expansion of epidemic lineages.

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Gene duplication as a major force driving the genome expansion in some giant viruses.

J Virol

December 2023

Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Giant viruses are noteworthy not only due to their enormous particles but also because of their gigantic genomes. In this context, a fundamental question has persisted: how did these genomes evolve? Here we present the discovery of cedratvirus pambiensis, featuring the largest genome ever described for a cedratvirus. Our data suggest that the larger size of the genome can be attributed to an unprecedented number of duplicated genes.

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Global Burden of Cardiovascular Diseases and Risks, 1990-2022.

J Am Coll Cardiol

December 2023

Department of Health Metrics Sciences, Institute for Health Metrics and Evaluation, School of Medicine, University of Washington, Seattle, Washington, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA. Electronic address:

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Viruses are a major cause of mortality and socio-economic downfall despite the plethora of biopharmaceuticals designed for their eradication. Conventional antiviral therapies are often ineffective. Live-attenuated vaccines can pose a safety risk due to the possibility of pathogen reversion, whereas inactivated viral vaccines and subunit vaccines do not generate robust and sustained immune responses.

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Changes to virus taxonomy and the ICTV Statutes ratified by the International Committee on Taxonomy of Viruses (2023).

Arch Virol

June 2023

The Biodesign Center for Fundamental and Applied Microbiomics, School of Life Sciences, Center for Evolution and Medicine, Arizona State University, Tempe, AZ, 85287-4701, USA.

This article reports changes to virus taxonomy and taxon nomenclature that were approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in April 2023. The entire ICTV membership was invited to vote on 174 taxonomic proposals that had been approved by the ICTV Executive Committee in July 2022, as well as a proposed revision of the ICTV Statutes. All proposals and the revised ICTV Statutes were approved by a majority of the voting membership.

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