13 results match your criteria: "Centre hospitalier de l'Université de Montréal and Montreal Heart Institute[Affiliation]"
Effect of red blood cell storage time in pediatric cardiac surgery patients: A subgroup analysis of a randomized controlled trial.
JTCVS Open
September 2023
Pediatric Intensive Care, Department of Pediatrics, Alberta Children's Hospital; University of Calgary, Calgary, Alberta, Canada.
Article Synopsis
- The study investigated whether fresh red blood cells (RBCs) would be more effective than standard-issue RBCs in preventing multiple organ dysfunction syndrome (MODS) in pediatric cardiac surgery patients.
- The analysis included 178 children, with findings showing no significant difference in the incidence of MODS between the two RBC groups, both having similar rates (approximately 48% for fresh and 43% for standard).
- The conclusion suggests that fresh RBCs do not provide a benefit over standard RBCs in preventing MODS, indicating the need for further research.
Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure.
N Engl J Med
January 2021
From the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), Amgen, Thousand Oaks (L.S., J.C.L., N.H., S.A.A., C.E.K.), and Cytokinetics, South San Francisco (F.I.M.) - all in California; Estudios Clínicos Latino América, Rosario, Argentina (R.D.); the Division of Cardiology, Duke University School of Medicine and Duke Clinical Research Institute, Durham (G.M.F.), and the University of North Carolina, Chapel Hill (K.F.A.) - both in North Carolina; the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College, London (J.G.F.C.) - both in the United Kingdom; Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy (M.M.); the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (S.D.S.); the University of Minnesota, Minneapolis (I.A.); Instituto Nacional de Cardiología, Mexico City (A.A.-M.); the Department of Cardiology, Herlev and Gentofte Hospital, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T.B.-S.); Saarland University, Universitätsklinikum des Saarlandes, Homburg, Germany (M.B.); Medical University of Vienna, Vienna (D.B.); Pontificia Universidad Católica de Chile, Santiago (R.C.); Complexo Hospitalario Universitario A Coruña, Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares, Instituto de Investigación Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain (M.G.C.-L.); the Departments of Cardiology and Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden (U.D.); Fundación Cardiovascular de Colombia, Floridablanca, Colombia (L.E.E.); University of Utah, Salt Lake City (J.C.F.); National and Kapodistrian University of Athens, Attikon University Hospital, Athens (G.F.); Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal (C.F.); Commenius University, Bratislava, Slovakia (E.G.); the Department of Cardiology, Queen Giovanna University Hospital and Medical University, Sofia, Bulgaria (A.R.G.); Libin Cardiovascular Institute and Cumming School of Medicine, University of Calgary, Calgary, AB (J.G.H.), and Montreal Heart Institute and Université de Montréal, Montreal (E.O.) - both in Canada; the Heart and Vascular Institute, Henry Ford Hospital, Detroit (D.E.L.); the National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.L.); Middlemore Hospital, Otahuhu, Auckland, New Zealand (M.L.); St. Vincent's Hospital Sydney, Darlinghurst, NSW, Australia (P.M.); University Clinic of Lomonosov, Moscow State University, Moscow (V.M.); Saitama Citizens Medical Center, Saitama, Japan (S.M.); Institute of Cardiology, Kyiv, Ukraine (A.P.); Wroclaw Medical University, Wroclaw, Poland (P.P.); Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo (F.J.A.R.); Vilnius University, Vilnius, Lithuania (P.S.); the University of Cape Town, Cape Town, South Africa (K.S.); the Internal Cardiology Department, St. Ann Hospital and Masaryk University Brno, Brno, Czech Republic (J.S.); the Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.M.S.); St. John of God Hospital, Budapest, Hungary (J.T.); AZ Sint-Lucas, Ghent, Belgium (H.V.); the University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.); the University of Groningen, Groningen, the Netherlands (A.A.V.); Dokuz Eylul University, Izmir, Turkey (M.B.Y.); and Université de Lorraine, INSERM Investigation Network Initiative Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional Universitaire de Nancy, Nancy (F.Z.), and Servier, Suresnes (C.V.) - both in France.
Background: The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown.
Methods: We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.
A proposed lung ultrasound and phenotypic algorithm for the care of COVID-19 patients with acute respiratory failure.
Can J Anaesth
October 2020
Department of Surgery, Sherbrooke University, Sherbrooke, QC, Canada.
Article Synopsis
- Pulmonary complications are the primary symptoms of COVID-19, with two distinct phenotypes identified: L-type (low elastance) and H-type (high elastance).
- Each phenotype exhibits unique clinical presentations, pathophysiological mechanisms, pulmonary mechanics, and imaging results, requiring different treatment approaches.
- A proposed management algorithm uses respiratory rate, oxygenation index, and lung ultrasound to help early identify patients needing intubation and improve monitoring of those with respiratory failure due to COVID-19.
Noninvasive Administration of Inhaled Nitric Oxide and its Hemodynamic Effects in Patients With Acute Right Ventricular Dysfunction.
J Cardiothorac Vasc Anesth
March 2019
Department of Anesthesiology and Division of Critical Care, Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada; Division of Critical Care, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada. Electronic address:
Objective: The authors aimed to assess the hemodynamic effects and demonstrate the feasibility of inhaled nitric oxide (iNO) in hemodynamically unstable patients with acute right ventricular (RV) dysfunction and to explore the safety profile of this approach.
Design: Retrospective cohort study.
Setting: Intensive care unit (ICU) of 2 tertiary care centers between January 2013 and 2017.
Load Adaptability in Patients With Pulmonary Arterial Hypertension.
Am J Cardiol
September 2017
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California; Cardiovascular Institute, Stanford University School of Medicine, Stanford, California.
Right ventricular (RV) adaptation to pressure overload is a major prognostic factor in patients with pulmonary arterial hypertension (PAH). The objectives were first to define the relation between RV adaptation and load using allometric modeling, then to compare the prognostic value of different indices of load adaptability in PAH. Both a derivation (n = 85) and a validation cohort (n = 200) were included.
View Article and Find Full Text PDFRight heart imaging in patients with heart failure: a tale of two ventricles.
Curr Opin Cardiol
September 2016
aDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA bResearch Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium cDepartment of Medical Imaging, Toronto General Hospital, University of Toronto, Toronto, Ontario dDepartment of Anesthesiology and Critical Care Division, Centre hospitalier de l'Universite de Montreal and Montreal Heart Institute, Montreal, Quebec, Canada.
Purpose Of Review: The purpose is to describe the recent advances made in imaging of the right heart, including deformation imaging, tissue, and flow characterization by MRI, and molecular imaging.
Recent Findings: Recent developments have been made in the field of deformation imaging of the right heart, which may improve risk stratification of patients with heart failure and pulmonary hypertension. In addition, more attention has been given to load adaptability metrics of the right heart; these simplified indices, however, still face challenges from a conceptual point of view.
Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: The SABPA study.
Nitric Oxide
May 2016
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
Background: Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear.
Objectives And Methods: Associations between the retinal vasculature, diastolic ocular perfusion pressure (DOPP) as measure of hypoperfusion, NO metabolites (NOx) and depression symptoms were assessed.
Background: As yet there is no firm evidence about the types of intervention that can reduce emergency room revisits. However, the literature on emergency room revisits suggests patient difficulties with managing their health problems and treatments after discharge may play a role.
Objectives: We carried out a randomized trial of an emergency department-based nursing intervention, but results showed no reduction in revisits (primary outcome).
Cohort Profile: Sympathetic activity and Ambulatory Blood Pressure in Africans (SABPA) prospective cohort study.
Int J Epidemiol
December 2015
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom Campus, South Africa.
Adapting to an over-demanding stressful urban environment may exhaust the psychophysiological resources to cope with these demands, and lead to sympathetic nervous system dysfunction. The evidence that an urban-dwelling lifestyle may be detrimental to the cardiometabolic health of Africans motivated the design of the Sympathetic activity and Ambulatory Blood Pressure in African Prospective cohort study. We aimed to determine neural mechanistic pathways involved in emotional distress and vascular remodelling.
View Article and Find Full Text PDFQuality of life and functional capacity in patients with atrial fibrillation and congestive heart failure.
J Am Coll Cardiol
January 2013
Montreal Heart Institute and Montreal Heart Institute Coordinating Center, Université de Montréal, Montreal, Quebec, Canada. Electronic address:
Objectives: This study sought to assess the impact of rhythm- versus rate-control treatment strategies and of underlying rhythm on quality of life and functional capacity in patients with atrial fibrillation (AF) and congestive heart failure (CHF).
Background: Although intention-to-treat and efficacy analyses have demonstrated similar cardiovascular outcomes in patients with AF and CHF randomized to rhythm or rate control, effects on quality of life remain to be determined.
Methods: The AF-CHF (Atrial Fibrillation and Congestive Heart Failure) trial randomized 1,376 patients to rhythm- or rate-control strategies.
Acute renal failure following lung transplantation: risk factors, mortality, and long-term consequences.
Eur J Cardiothorac Surg
January 2012
Division of Thoracic Surgery, Centre Hospitalier de l'Université de Montréal, and Montreal Heart Institute Research Center, Université de Montréal, Montréal, Quebec, Canada.
Objective: Acute renal failure (ARF) frequently complicates lung transplantation. This study determined the prevalence, predictive factors, and consequences of ARF on long-term renal function and survival.
Methods: One hundred and seventy-four lung transplantation recipients were divided into two groups based on the presence or absence of ARF defined as a 50% decrease in creatinine clearance from baseline (group I: 67 patients with ARF; group II: 107 patients without ARF).
Post-varicella arteriopathy of childhood: natural history of vascular stenosis.
Neurology
February 2005
Cerebrovascular Disease Centre, Centre hospitalier de l'Université de Montréal and Montreal Heart Institute, Montreal, Quebec.
Objective: To determine the course of vascular changes in childhood post-varicella arteriopathy (PVA) and its relationship to recurrent arterial ischemic stroke or TIA (AIS/TIA).
Methods: Subjects were children with AIS/TIA occurring <1 year after varicella, ischemic localization consistent with unilateral disease affecting the supraclinoid internal carotid artery or proximal anterior or middle cerebral arteries, and no identified AIS/TIA etiology other than PVA. Charts, brain MRI, and sequential cerebral vessel imaging (selective cerebral angiography or MR angiography [SCA/MRA]) were retrospectively reviewed.
Increased anticardiolipin antibody IgG titers do not predict recurrent stroke or TIA in children.
Neurology
January 2004
Cerebrovascular Disease Centre, Division of Neurology, Department of Medicine, Centre hospitalier de l'Université de Montréal and Montreal Heart Institute, Quebec, Canada.
Background: Increased anticardiolipin antibody (ACLA) immunoglobulin (Ig) G titers are commonly found in children with arterial ischemic stroke (AIS) or TIA (AIS/TIA). The associated risk of recurrent thromboembolism is unknown.
Objective: To determine the risk of recurrent thromboembolism associated with persistently increased ACLA titers of the IgG isotype in children with AIS/TIA.