[Topical imiquimod for the treatment of anogenital warts in an infant].

Background: Treatment of anogenital warts (AW) in children and infants is painful because of the destructive techniques involved, as a result of which general anaesthesia may be required. For adults, topical imiquimod is an efficient and well-tolerated product used for these lesions. Here, we report a case demonstrating the benefits of topical imiquimod in the treatment of AW in infant.

[Pseudomonas aeruginosa unilateral endogenous endophthalmitis in a preterm infant: a case report].

Endogenous endophthalmitis is a rare eye disease, affecting vulnerable subjects (such as preterm or older elderly subjects), with reserved visual and sometimes vital prognosis. We present a preterm boy, born at 35 weeks and 2 days gestation, who developed a right eye Pseudomonas aeruginosa endogenous endophthalmitis secondary to a left-foot peripherical catheter-infection-associated bacteremia. He had a first intravenous antibiotic therapy associating third-generation cephalosporin and fluoroquinolone, then Ceftazidime® by intravitreous injection and a subconjunctival injection of betamethasone.

Fusion of MRIs and CT scans for surgical treatment of cholesteatoma of the middle ear in children.

Objective: To evaluate the efficiency of diffusion-weighted magnetic resonance imaging (MRI) and high-resolution computed tomographic (CT) scan coregistration in predicting and adequately locating primary or recurrent cholesteatoma in children.

Design: Prospective study.

Setting: Tertiary care university hospital.

[Placenta percreta at first trimester of pregnancy. Diagnostic and decision-making difficulties: about a case and a review of the literature].

We report the case of a 28-year-old patient, G9P4. Her last pregnancy was marked by a failure of a medical termination at 4 gestational weeks. She consulted as a matter of emergency for acute abdominal pain with moderated hemoperitoneum at 13 weeks of gestation.

[Successful use of combined corticosteroids and rituximab in the treatment of recalcitrant epidermolysis bullosa acquisita].

Background: Epidermolysis bullosa acquisita (EBA) is a rare autoimmune subepidermal blistering disease; it is potentially serious and is often refractory to conventional treatments, including corticosteroids. We report a new case of successful treatment of EBA using rituximab (anti-CD20 antibody) without relapse after 1 year of follow-up.

Case Report: A 76-year-old man was seen for blisters of the skin and mucosa, atrophic scars and milia on areas of friction.

Diffusion-weighted MR imaging for evaluation of pediatric recurrent cholesteatomas.

Objective: To compare the efficiency of diffusion-weighted MR imaging (MRI) vs. high resolution CT in predicting recurrent or residual cholesteatoma in children who underwent prior middle ear surgery.

Design: Prospective study.

Morphoea-like plaques revealing an eosinophilic (Shulman) fasciitis.

Eosinophilic fasciitis (EF) is a connective-tissue disease characterized by thickened fascia. Involvement of the dermis may occur during the progression of the disease, characterized clinically by morphoea-like plaques (MLPs). This more superficial feature of EF carries a poor prognosis, suggestive of refractory EF that requires intensive therapy.

Large plaque-type blue naevus with subcutaneous cellular nodules.

We report a new case of 'large plaque-type blue naevus (PTBN) with subcutaneous cellular nodules' involving the breast. A 25-year-old-woman presented with a large plaque, 140 x 100 mm in size, on the right chest wall involving the right breast, associated with recent subcutaneous nodules. Histopathological examination revealed features of cellular and common blue naevus.

[Diffuse systemic sclerosis after occupational exposure to trichloroethylene and perchloroethylene].

Background: Diffuse systemic sclerosis (DSS) is an autoimmune disease that is most often endogenous but which can also be induced by exogenous substances of occupational origin.

Patients And Methods: We report a case of DSS involving prolonged intermittent occupational exposure to solvents (trichloroethylene [TCE] and perchloroethylene [PCE]). The disease was rapidly fatal with cardiac arrest secondary to myocardial fibrosis.

[Abdominal migration of a levonorgestrel-releasing intrauterine device. Case report and review of the literature].

We report the case of a 27-year-old woman in amenorrhea after the installation of a levonorgestrel releasing intra-uterine device, 3 years previously. In front of pelvic continuing pains, paraclinic explorations diagnosed the DIU-LNG in intra-abdominal situation. An exploratory laparoscopy was realized and allowed its ablation.

[Boerhaave syndrome and pregnancy. A case report and review of the literature].

The syndrome of Boerhaave is a rare affection, corresponding to a spontaneous rupture of the oesophagus, the prognosis of which depends on the precocity of cares. Clinically, it is characterized by a set of three: efforts of vomitings, thoracic pain and subcutaneous emphysema. We report the first case of spontaneous rupture of the oesophagus in a 3-month pregnant woman, further to incoercible vomiting.

[Rhabdomyolysis with major hypokalemia secondary to chronic glycyrrhizic acid ingestion].

Intoxication by glycyrrhizic acid is a well-known cause of the apparent mineralocorticoid excess syndrome. It causes hypokalemia by inhibiting the enzyme 11-beta-hydroxysteroid dehydrogenase. We report a case of hypokalemic rhabdomyolysis secondary to chronic glycyrrhizic acid intoxication.

[Hypocomplementemic urticarial vasculitis].

Hypocomplementemic urticarial vasculitis is a rare disorder characterized by the presence of C1q precipitins associated with a syndrome of urticarial vasculitis, arthralgias, ocular inflammation and obstructive-lung disease. We report the case of a 48-year-old woman with hypocomplementemic urticarial vasculitis. Because of dependance to corticosteroids, cyclophosphamide-pulse therapy was started and resulted in significant clinical improvement.

[Lupus profundus and myelopathy].

Background: We report a case of myelopathy during the course of lupus profundus that is unique to our knowledge.

Case-report: A 29-year-old woman had lupus profundus since 1999, initially associated with thrombopenia (28,000 platelets/mm3) treated with corticosteroids for 6 months. Several nodular eruptions occurred from 1999 to 2004.

[Bullous paraneoplastic acrokeratosis].

Background: Bullous lesions of acral distribution are an uncommon finding in Bazex's syndrome (acrokeratosis paraneoplastica). We report here one of these rare cases.

Patients And Methods: A 65 year-old-man, an alcoholic and a smoker, presented with characteristic lesions of Bazex's acrokeratosis paraneoplastica associated with a right cervical lymph node mass.

Fever of unknown origin in adults: evaluation of 144 cases in a non-university hospital.

The spectrum of diseases found in series of fever of unknown origin shows variation in relation to selection bias; particularly, selection of the most difficult cases in tertiary reference university centres. We present a series of 144 patients presenting to a non-university hospital between 1999 and 2005 (secondary level of the health care system) with a community-acquired fever of unknown origin. In 37 cases (25.

[Sarcoidosis presenting as an intrascrotal mass].

Introduction: Sarcoidosis is a multisystem disorder that rarely involves the genitourinary tract.

Case: A 35-year-old man had intrascrotal extratesticular mass. Surgical exploration found noncaseating granulomatous inflammation.

[Hypereosinophilic syndrome and orbital inflammatory pseudotumor].

Introduction: Idiopathic hypereosinophilic syndrome is defined by the combination of persistent eosinophilia and evidence of tissue damage. It is a diagnosis of exclusion.

Case: We report the case of a 53-year-old man with idiopathic hypereosinophilic syndrome associated with an orbital inflammatory pseudotumor.

Brain abscesses caused by Abiotrophia defectiva: complication of immunosuppressive therapy in a patient with connective-tissue disease.

We report the case of a patient who developed brain abscesses caused by Abiotrophia defectiva. The patient was treated with prednisone and cyclophosphamide for connective-tissue disease (lupus-Sjögren's overlap syndrome). A few cases of central nervous system infections due to Abiotrophia species have been previously reported in immunocompetent patients following neurosurgical procedures, suggesting possible introduction of this organism at the time of surgery.

[Gangliocytic paraganglioma of the pancreas with bone metastasis].

We report the case of a 50-years-old man who underwent sequential curative resection for gangliocytic paraganglioma of the pancreas with metachronous sternal metastasis. Gangliocytic paraganglioma are mainly located on the duodenum but several localizations have been reported, including on the digestive tract. Locoregional lymph node metastases are possible and prove their malignant potential but, to our knowledge, this observation is the first documented case of distant metastasis.

[Treatment of coronary insufficiency in diabetics. Part 3: chronic coronary insufficiency].

The drug treatment of chronic coronary insufficiency in diabetic patients is now well defined. Platelet antiaggregants, especially aspirin, must be prescribed in the long-term or even indefinitely. Other drugs (beta-blockers, calcium channel blockers, nitrates, etc.

[Treatment of coronary insufficiency in diabetics. Part 1: objectives and targets].

Coronary insufficiency affects 55% of insulin-dependant diabetics and is responsible for 60% of deaths in this population. Its particular severity is essentially due to the severity of coronary atherosclerosis, which is usually multi-vessel, involves both large trunks and microcirculation, is made of frequently lipid-rich and therefore fragile plaques, and is accompanied by abnormal but specific reactions of the arterial wall (tendency to vasoconstriction and increased neointimal proliferation after trauma). Coronary atherosclerosis is also often associated with HT, lower limb arteriopathy or cerebral atherosclerosis.

[Treatment of coronary insufficiency in diabetics: Part 2: acute coronary insufficiency].

Treatment of acute coronary insufficiency in diabetics--recent myocardial infarction (MI--unstable angina--uses the same modalities as in the absence of diabetes. Thrombolytics improve the prognosis of MI, although the hospital mortality remains about two fold in the presence of diabetes. Primary angioplasty has an identical success rate, but restenoses are significantly more frequent in diabetics.

[Evaluation of changing antibiotic prescription habits in a general hospital center].

Objective: Two audits of antibiotic prescriptions were conducted within the framework of the fight against bacterial resistance conducted at the Valence Hospital Center (Drôme, France). The first was made between July 1st and 31st 1998 and the second between December 15th 1999 and January 15th, 2000, both based on the prospective observation scheme.

Patients And Methods: We studied prescriptions written for antibiotics, recording the compound prescribed, the therapeutic indication, the type of infection and the prescriber.

[Subacute infectious endocarditis due to the agent of cat scratch fever: Bartonella henselae].

The diagnosis of severe mitral stenosis with left atrial thrombus was rectified at valvular replacement in a 48-year old immuno-competent man who was a cat owner. The mass in the left atrium was, in fact, a large endocarditic vegetation. Pre- and postoperative blood cultures were negative as was culture of the excised mitral valve.