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Centre for Reproductive Medicine[Affili... Publications | LitMetric

1,863 results match your criteria: "Centre for Reproductive Medicine[Affiliation]"

Lithocholic acid phenocopies anti-ageing effects of calorie restriction.

Nature

December 2024

State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.

Calorie restriction (CR) is a dietary intervention used to promote health and longevity. CR causes various metabolic changes in both the production and the circulation of metabolites; however, it remains unclear which altered metabolites account for the physiological benefits of CR. Here we use metabolomics to analyse metabolites that exhibit changes in abundance during CR and perform subsequent functional validation.

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Ectopic pregnancy.

Nat Rev Dis Primers

December 2024

Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

Ectopic pregnancy, defined as the implantation of a developing pregnancy outside of the endometrial cavity of the uterus, is the leading cause of early-pregnancy maternal mortality. The majority of ectopic pregnancies implant in a fallopian tube. Acute complications may include rupture of the fallopian tube or rupture of ectopic pregnancy, haemorrhage and hypovolaemic shock, or occur secondary to treatments such as emergency surgery or blood transfusions, and ultimately increase the risk of maternal death.

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Robotic-Assisted Microsurgery in Gender-Affirming Phalloplasty.

Ann Plast Surg

January 2025

Centre for Reproductive Medicine and Andrology, Department of Clinical and Surgical Andrology, University Hospital Muenster, Muenster, Germany.

Genital gender-affirming masculinization surgeries require handling of small vessels and nerves handling in deep planes. Since the introduction of the Symani Surgical System for robotic-assisted microsurgery in clinical practice, its value in handling small and deep vessels via additional distal motion axes, motion scaling, and tremor elimination has been demonstrated. We combined the Symani with the robotic exoscope RoboticScope to achieve maximum flexibility and ergonomics for the microsurgeon.

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Introduction: Hysterosalpingography (HSG) and hysterosalpingo-foam sonography (HyFoSy) are commonly used tubal patency tests during the fertility work-up. Besides its diagnostic purpose, HSG with oil-based contrast can also be applied for its fertility-enhancing effect, by tubal flushing. HyFoSy is considered as less painful compared with HSG, it lacks exposure to iodinated contrast medium and ionising radiation.

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Triggering oocyte maturation in in vitro fertilization treatment in healthy responders: a systematic review and network meta-analysis.

Fertil Steril

November 2024

King's Fertility, Fetal Medicine Research Institute, London, United Kingdom; Faculty of Life Sciences & Medicine, Department of Women's and Children's Health, King's College London, London, United Kingdom.

Article Synopsis
  • This study aimed to evaluate the effectiveness and safety of various hormone triggers (hCG, GnRH agonist, dual, and double triggers) in women undergoing ovarian stimulation for IVF through a systematic review and network meta-analysis of 12 randomized controlled trials.
  • A total of 1,931 women were analyzed, with the primary outcomes focused on clinical pregnancy rates (CPR), live birth rates (LBR), and the incidence of ovarian hyperstimulation syndrome (OHSS).
  • The results indicated that the dual trigger had the best potential for higher CPR, while the GnRH agonist trigger was associated with significantly lower OHSS rates compared to hCG, but overall, no major differences in o
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Background: To prevent the transfer of embryos affected by monogenic conditions and/or chromosomal defects, preimplantation genetic testing (PGT) requires trophectoderm biopsy and cryopreservation. In 2-6% of biopsies, the diagnosis may be inconclusive due to DNA amplification failure or low-quality results. In these cases, a round of re-warming, re-biopsy, and re-cryopreservation is required to obtain a genetic diagnosis.

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Objective: maturation (IVM) is an advanced technique and an alternative to conventional fertilization (IVF). It is safe, effective, and cost-effective in patients with polycystic ovary syndrome (PCOS). However, no clinical guidelines state that IVM could work without compromised pregnancy outcomes in patients with PCOS.

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Objective: To investigate pregnant women's preferences for risks of vaginal and caesarean birth, including possible impacts on future fertility.

Methods: In this discrete choice experiment, low-risk nulliparous pregnant women recruited after 28 weeks of gestation evaluated eight choice sets, each between two different hypothetical births scenarios which intermixed the risks of planned caesarean or vaginal birth. Scenarios consisted of six attributes: pain, maternal health, neonatal health, risk of unplanned intervention, impact on fertility and risk of complications in the next pregnancy.

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Background: Traditional methods of training in ultrasound technology make it difficult for postgraduate reproductive medicine students to rapidly develop into doctors who can perform clinical examinations independently. It is necessary to explore an efficient method for ultrasound training. The purpose of this study was to investigate whether the step-by-step (SBS) teaching improves the ultrasound diagnosis and clinical work level of reproductive medicine graduate students.

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Reply: Emerging evidence of endometrial compaction in predicting ART outcomes.

Hum Reprod Open

October 2024

Department of Women's and Children's Health, Centre for Women's Health Research, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

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The need for fertility education arises from changing patterns of family formation in recent times. Young people feel unprepared for how best to plan their career and family and have little idea of the various factors that may influence their fertility later in their life. Research shows young people would like to know more and need the information to be conveyed in a way that is engaging and helps them to integrate it at their current life stage.

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The prevalent histological variant within differentiated thyroid carcinoma is papillary thyroid carcinoma, also known as PTC. The study investigated the clinical performance of serum hsa_circ_0001955 in predicting the prognosis of PTC treated with radical thyroidectomy and iodine 131 nail clearance. The relative expression of serum circ_0001955 of PTC patients was detected before and after accepting radical thyroidectomy combined with 131I thyroid remnant ablation by RT-qPCR.

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Lysosome toxicities induced by nanoparticle exposure and related mechanisms.

Ecotoxicol Environ Saf

November 2024

Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, China. Electronic address:

Article Synopsis
  • * Lysosomes are vital for breaking down cellular materials and play a key role in processes like communication between organelles and immune responses, making their proper function important for health.
  • * The review discusses how NPs disrupt lysosomal function by altering their acidic environment and causing damage to their membranes, while also highlighting specific proteins involved in this process, aiming to enhance understanding for better use of NPs in medical applications.
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Article Synopsis
  • * Fifty-two fertility specialists reached an agreement on personalizing gonadotropin dosages according to factors like age and BMI, and preferred fresh transfers for low to normal responders while suggesting freeze-all strategies for high responders.
  • * The AMPLITUDE consensus emphasizes the need for optimizing ovarian stimulation protocols in assisted reproductive technology, with recommendations for future research to further enhance treatment outcomes.
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Article Synopsis
  • * Involving 430 women across 860 cycles, the research compares outcomes from a standard stimulation cycle versus one that included early GnRH antagonist pretreatment.
  • * Results indicate that the pretreatment significantly increases the total number of retrieved COCs and mature oocytes, suggesting benefits for fertility treatment protocols.
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Ribosomal RNA (18S, 5.8S, 28S) gene clusters in genomes form regions that consist of multiple tandem repeats. They are located on a single or several pairs of chromosomes and play an important role in the formation of the nucleolus responsible for the assembly of ribosome subunits.

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The web-based Pleasure&Pregnancy programme in the treatment of unexplained infertility: a randomized controlled trial.

Hum Reprod

December 2024

Department of Obstetrics and Gynaecology, Centre for Reproductive Medicine, Amsterdam UMC Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Study Question: Does offering the Pleasure&Pregnancy (P&P) programme rather than expectant management improve naturally conceived ongoing pregnancy rates in couples diagnosed with unexplained infertility?

Summary Answer: The P&P programme had no effect on the ongoing pregnancy rates of couples with unexplained infertility.

What Is Known Already: Underpowered studies suggested that face-to-face interventions targeting sexual health may increase pregnancy rates. The impact of an eHealth sexual health programme had yet to be evaluated by a large randomized controlled trial.

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Polycystic ovary syndrome (PCOS) represents a significant cause of infertility among women of reproductive age. Studies have established a close association between granulosa cells (GCs) and the abnormal follicle formation and ovulation processes characteristic of PCOS. The interactions among hsa_circ_0043533, miR-409-3p, and BCL2 were verified through luciferase activity assays.

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To analyze whether combinations of polymorphisms within FSHR gene influence ovarian response (OR) to stimulation. A multicenter prospective cohort study was conducted from 11/2016-06/2019 in Europe and Asia including predicted normo-responders under 38y. Patients underwent ovarian stimulation using fixed-dose 150 IU rFSH in a GnRH antagonist protocol.

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Article Synopsis
  • Ensuring women's sexual and reproductive health (SRH) is crucial for human rights and the UN Sustainable Development Goals, but there's limited data on these issues in China.
  • A national survey from 2019 to 2021 included nearly 13,000 women aged 20-49, examining their SRH experiences, gynecological diseases, and STDs across 15 Chinese provinces.
  • Results showed trends like decreased age at menarche and increased early sexual activity, with significant health issues: about 50% had gynecological diseases and 22.2‰ reported STDs, highlighting regional disparities in health outcomes.
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Effects of platelet-rich fibrin on human endometrial stromal cells behavior in comparison to platelet-rich plasma.

Front Cell Dev Biol

September 2024

Centre for Reproductive Medicine, Women and Children's Hospital, Qingdao University, Qingdao, China.

Introduction: Intrauterine transfusion of platelet-rich plasma (PRP) has become a new treatment for thin endometrium (TE) in recent years, but its low efficacy due to rapid release of growth factors limits its clinical use. Platelet-rich fibrin (PRF) starts the coagulation cascade reaction immediately after the blood comes into contact with the test tube. The natural coagulation process results in stable platelet activation and the slow release of growth factors.

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Objectives: To evaluate whether embryo transfers at blastocyst stage improve the cumulative live birth rate after oocyte retrieval, including both fresh and frozen-thawed transfers, and whether the risk of obstetric and perinatal complications is increased compared with cleavage stage embryo transfers during in vitro fertilisation (IVF) treatment.

Design: Multicentre randomised controlled trial.

Setting: 21 hospitals and clinics in the Netherlands, 18 August 2018 to 17 December 2021.

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Study Question: How do transfeminine adolescents and their parents experience fertility preservation via testicular sperm extraction (TESE)?

Summary Answer: Participants experienced the TESE process positively when provided with appropriate guidance to navigate the decisional dilemma between preserving future biological parenthood and the pressure to start puberty suppression early.

What Is Known Already: Sperm banking through ejaculation is not feasible for all transfeminine adolescents due to genital dysphoria and early puberty; for this group, TESE is the only alternative. However, during early puberty, they must postpone or pause puberty suppression until spermatogenesis is fully developed.

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