2 results match your criteria: "Centre for Natural Sciences and Humanities[Affiliation]"
Hypericin-glucamine antimicrobial photodynamic therapy in the progression of experimentally induced periodontal disease in rats.
Photodiagnosis Photodyn Ther
March 2019
São Paulo State University (Unesp), School of Dentistry Araraquara, Department of Diagnosis and Surgery, Araraquara, Brazil. Electronic address:
Objective: To evaluate the effect of antimicrobial photodynamic therapy (aPDT) using the photosensitizer hypericin-glucamine in the progression of experimentally induced periodontal disease (PD) in rats.
Material And Methods: Subgingival ligatures were inserted around the upper second molars of 30 rats. After 7 days (Baseline), the animals were randomly distributed into 3 experimental (n = 5) groups: Hypericin-glucamine; LED (amber LED, 700 mA, 590 nm, 90 mW, 34.
Applying machine learning techniques for ADME-Tox prediction: a review.
Expert Opin Drug Metab Toxicol
February 2015
Federal University of ABC (UFABC), Centre for Natural Sciences and Humanities, Santa Adélia Street, 166, Bangu, Santo André -SP , Brazil.
Introduction: Pharmacokinetics involves the study of absorption, distribution, metabolism, excretion and toxicity of xenobiotics (ADME-Tox). In this sense, the ADME-Tox profile of a bioactive compound can impact its efficacy and safety. Moreover, efficacy and safety were considered some of the major causes of clinical failures in the development of new chemical entities.
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