Zero-Valent Copper Catalysis Enables Regio- and Stereoselective Difunctionalization of Alkynes.

The development of a metallic copper-based catalyst system remains a significant challenge. Herein, we report the synthesis of highly stable, active, and reusable Cu0 catalyst for the carboboration of alkynes using carbon electrophiles and bis(pinacolato)diboron (B2pin2) as chemical feedstocks to afford di- and trisubstituted vinylboronate esters in a regio- and stereoselective manner with appreciable turnover number (TON) of up to 2535 under mild reaction conditions. This three-component coupling reaction works well with a variety of substituted electrophiles and alkynes with broad functional group tolerance.

Bioinspired design of DNA in aqueous ionic liquid media for sustainable packaging of horseradish peroxidase under biotic stress.

We show that a combination of DNA and ionic liquid significantly increases the stability and activity of HRP and achieves a 4.8-fold higher peroxidase activity than PBS buffer. Also, HRP retains 84% of its activity in IL+DNA compared to 24% in PBS against trypsin digestion.

Synthesis, Trans-Cis Photoisomerization, Fluorescence Decay Studies of Methoxy Ester Functionalized Alkoxy Side Chain Azobenzene Compounds and Their Photoluminescence Dynamics.

In this study, a series of new methoxy ester functionalized core fluorinated, chloro-fluorinated azobenzene derivatives were synthesized. The molecular structures of the azobenzene derivatives (3a-3c and 4a-4c) were confirmed through various analytical methods, with variations in the alkoxy chain length on one end of the aromatic ring. Optical absorption studies of 3a, 3b revealed π-π* transitions around 368-392 nm.

Gold nanoparticle encapsulated hybrid MOF: synthesis, characterization, and co-drug delivery of 5-fluorouracil and curcumin.

The unique features of Metal-Organic Frameworks (MOFs), including structural flexibility, high surface area, and variable pore size, have drawn attention in cancer therapy. However, despite advances in surface functionalization, engineering structural features, and porosity, achieving controlled release, stability, scalability, and toxicity remains a challenge. The current study reports gold nanoparticle (AuNP) encapsulated dual metal-organic frameworks (MOFs) comprising zeolitic imidazolate (ZIF8) and cobalt-imidazole (ZIF67) by a simple precipitation method for dual drug delivery applications.

Extraction of diosgenin using different techniques from fenugreek seeds- A review.

Diosgenin, falls under the category of steroidal saponin present in fenugreek seeds (Trigonella foenum-graecum) in the amount of 0.2-09%. This compound possesses certain pharmacological characteristics like anti-inflammatory, anti-cancer, anti-oxidant etc.

Antibody-modified 2D MXene nanosheet probes for selective, picolevel detection of cancer biomarkers.

Cancer biomarkers are crucial indicators found in clinical samples, playing a key role in early detection, diagnosis, and treatment of cancer. Detecting these biomarkers with high sensitivity is essential for early diagnosis, especially in aggressive cancers like lung cancer, which is the leading cause of cancer-related deaths. Carcinoembryonic antigen (CEA) is a critical biomarker for lung cancer, and its detection aids in identifying the disease at an early stage.

Catalyst to cure: applications of a new copper-based nanocatalyst in organic synthesis and cancer treatment.

This research explores the diverse applications of copper(0) nanoparticles grafted onto boron carbon nitride nanosheets, using dill leaf extract as a natural reducing and stabilizing agent. This nanocatalyst efficiently catalyzes the synthesis of tetrazole and aniline derivatives, demonstrating good recyclability and promising potential in cancer therapy. By merging sustainability with innovation, this nanocatalyst offers transformative solutions in both synthesis and medical fields.

Reliability of Multi-Emissive Carbon Quantum Dots for Multiplexing; Assessing the Figures of Merit.

Incredible properties of quantum dots (QDs) have once again been acclaimed with this year's (2023) Nobel prize in chemistry. On the other hand, the invention of multicolour molecular imaging of cell surface receptors for tumour diagnosis by Koyama and group has opened up a new era in diagnostics. Among them carbon quantum dots (CQDs) are interesting class of fluorescent nanomaterials, superior in terms of low toxicity, high solubility and biocompatibility along with simple and cost-effective synthesis processes unlike the traditional metal chalcogenide or perovskite quantum dots.

Palladium-Catalyzed, Regio-/Stereo- and Enantiospecific Anti-Carboxylation of Unactivated Internal Allenes.

We report herein a directing group-controlled, palladium-catalyzed, regio-, stereo-, and enantiospecific anti-carboxylation of unactivated, internal allenes enabled via the synergistic interplay of a rationally designed bidentate directing group, palladium catalyst, and a multifunctional acetate ligand. The corresponding trans allyl ester was obtained in excellent yields with exclusive δ-regioselectivity and anti-carboxypalladation stereocontrol. The acetate ligand of the palladium catalyst controls the regio-, stereo- and enantioselectivity in the desired transformation.

Quinoline hybrid derivatives as effective structural motifs in the treatment of tuberculosis: Emphasis on structure-activity relationships.

Mycobacterium tuberculosis (MTB/Mtb) is the causative agent of tuberculosis (TB), a highly infectious serious airborne illness. TB usually affects the lungs, in 25 % of patients (children or immune impaired adults), mycobacteria can enter the blood stream and infect other bodily areas such the meninges, pleura, lymphatic system, genitourinary system, bones, and joints. Currently, the most challenging aspect of treating this illness is the ineffectiveness of the most potent first-line anti-TB medications, isoniazid, rifampin, pyrazinamide, and ethambutol, which can result in multidrug-resistant TB (MDR-TB), extensively drug-resistant TB (XDR-TB), and in rare instances, completely drug-resistant TB (TDR-TB).

Synthesis, characterization, and evaluation of pyrimidinone-linked thiazoles: DFT analysis, molecular docking, corrosion inhibition, and bioactivity studies.

The paper describes the construction of a new series of pyrimidinone-linked thiazole derivatives through bromination of the initial Biginelli reaction product followed by the Hantzsch thiazole synthesis route. Various analytical techniques, including FT-IR, H NMR, C NMR, and LCMS analysis, were employed to confirm the formation of the products. The synthesized compounds were primarily evaluated for their antibacterial activity, with a specific focus on their IC values.

Engineering the Coordination Environment in the Silver(I)- and Ruthenium(II)--Heterocyclic Carbene Complexes in Instigating the Electrocatalytic Hydrogen Evolution Reaction.

The quest for cost-efficient and high-performance electrocatalysts towards electrocatalytic water splitting is a key and an interdisciplinary area of study. Considerable progress is being driven by developments in the field of energy research. In a fundamental study, we have synthesized NHC precursors ( and ) and corresponding metal-NHC complexes of silver(I)- ( and ) and ruthenium(II)- ( and ) of a N-heterocyclic carbene-based ligand type incorporating coumarins.

Ligand modulated charge transfers in Z-scheme configured Ni-MOF/g-CN nanocomposites for photocatalytic remediation of dye-polluted water.

The development of photocatalysts must be meticulous, especially when they are designed to degrade hazardous dyes that cause mutagenesis and carcinogenesis. In this meticulous approach, Ni-based metal-organic frameworks with different ligands, including terephthalic acid (NTP), 2-aminoterephthalic acid (NATP), and their composite with g-CN (NTP/GCN, and NATP/GCN) have been synthesized using hydrothermal method. Structural analysis by XRD and ATR-IR revealed synergistic properties due to robust chemical interactions between the NATP-MOFs and GCN systems.

Quinoline Synthesis: Nanocatalyzed Green Protocols-An Overview.

Heterocyclic compounds are of great interest in our daily lives. They are widely distributed in nature and are synthesized in laboratories. Heterocycles play an important role in the metabolism of all living cells, including vitamins and coenzyme precursors like thiamine and riboflavin.

Infrared thermochromic antenna composite for self-adaptive thermoregulation.

Self-adaptive thermoregulation, the mechanism living organisms use to balance their temperature, holds great promise for decarbonizing cooling and heating processes. This functionality can be effectively emulated by engineering the thermal emissivity of materials to adapt to background temperature variations. Yet, solutions that marry large emissivity switching ( ) with scalability, cost-effectiveness, and design freedom are still lacking.

Green Approach for the Synthesis of 2-Phenyl-2-indazoles and Quinazoline Derivatives Using Sustainable Heterogeneous Copper Oxide Nanoparticles Supported on Activated Carbon and OER Study.

This research work reports the synthesis of copper oxide (CuO) nanoparticles supported on activated carbon by a simple impregnation method using 2-propanol as a green solvent, followed by calcination. The synthesized CuO@C is used as an efficient heterogeneous nanocatalyst for the synthesis of 2-indazoles and quinazolines utilizing commercially available 2-bromobenzaldehydes, primary amines, and sodium azide under ligand-free and base-free conditions. The present methodology demonstrates the formation of new N-N, C-N, and C═N bonds under one-pot reaction conditions using PEG-400 as a green solvent.

Cellulose acetate-based polymer electrolyte for energy storage application with the influence of BaTiO nanofillers on the electrochemical properties: A progression in biopolymer-EDLC technology.

The bio-based solid polymer electrolyte serves as a promising choice for the next generation of energy storage devices to meet the requirement of green chemistry. In the current research, a green plasticized magnesium ion-conducting biopolymer electrolyte was developed using simple solution casting method for Electric Double Layer Capacitors (EDLC) applications. The biopolymer Cellulose Acetate (CA) as the host polymer, with varying concentrations of BaTiO as the nanofiller, Mg(CFSO) as the ionic dopant, and PEG as the plasticizer.

Optically induced trion formation and its control in a MoS/graphene van der Waals heterostructure.

Monolayer 2D transition metal dichalcogenides (TMDs) show high sensitivity to the local dielectric environment, leading to modulation of their optoelectronic properties. Here, we report on the formation of localized trions in a MoS/few-layer graphene van der Waals heterostructure. We performed temperature-dependent photoluminescence and Raman studies down to 80 K, to understand the mechanism for localized charge excitation, which shows contrasting behaviour with MoS/SiO.

Colorimetric and Fluorimetric Detection of Fe(III) Using a Rhodamine-Imidazole Hydrazone Based Chemosensor: Photophysical Properties, DFT, TGA, and DSC Studies.

Rhodamine-imidazole hydrazones (RIH-1 & RIH-2) based chemosensors have been synthesized. These are characterised and evaluated by FT-IR spectroscopy, H-NMR, C-NMR, LCMS, absorption and fluorescence spectroscopy. These chemosensors exhibit enhanced sensitivity and selectivity in detecting the biologically significant Fe metal ion through both colorimetric and fluorescence changes.

Unveiling the potential of emergent nanoscale composite polymer electrolytes for safe and efficient all solid-state lithium-ion batteries.

Solid-state polymer electrolytes (SSPEs) are promising materials for Li-ion batteries due to their enhanced safety features, which are crucial for preventing short circuits and explosions, replacing traditional liquid electrolytes with solid electrolytes are increasingly important to improve battery reliability and lifespan. There are essentially three-types of solid-state electrolytes such as solid polymer electrolyte, composite based polymer electrolyte and gel-based polymer electrolyte are largely used in battery applications. Additionally, battery separators must have high ionic conductivity and porosity to boost safety and performance.

PFOA remediation from kaolinite soil by electrokinetic process coupled with activated carbon/iron coated activated carbon - permeable reactive barrier.

This study applied electrokinetic (EK) in situ soil remediation for perfluorooctanoic acid (PFOA) removal from kaolinite soil. The kaolinite soil was spiked with 10 mg/kg PFOA for the EK treatment using Sodium Cholate bio-surfactant coupled with Activated Carbon (AC) or iron-coated Activated Carbon (FeAC) permeable reactive barrier (PRB). The study also evaluated the impact of AC and FeAC PRBs' position on the EK process performance.