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Frailty, lifestyle, genetics and dementia risk.

J Neurol Neurosurg Psychiatry

April 2022

Geriatric Medicine Research, Centre for Health Care of the Eldery, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada

Objective: To optimise dementia prevention strategies, we must understand the complex relationships between lifestyle behaviours, frailty and genetics.

Methods: We explored relationships between frailty index, healthy lifestyle and polygenic risk scores (all assessed at study entry) and incident all-cause dementia as recorded on hospital admission records and death register data.

Results: The analytical sample had a mean age of 64.

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