1,016 results match your criteria: "Centre for Evidence-Based Medicine[Affiliation]"

Funding matters: time to update PRISMA?

J Clin Epidemiol

January 2025

Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK; Department of Analytical, Environmental & Forensic Sciences, Institute of Pharmaceutical Sciences, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, UK.

View Article and Find Full Text PDF

Background: Randomised trials conducted from 2006 to 2021 indicated that vitamin D supplementation (VDS) was able to prevent severe COVID-19 and acute respiratory infections (ARI). However, larger randomised trials published in 2022 did not confirm the health benefits of VDS in COVID-19 patients.

Objective: To examine through a systematic review with meta-analysis the characteristics of randomised trials on VDS to COVID-19 patients and admission to intensive care unit (ICU), and of randomised trials on VDS for the prevention of ARI.

View Article and Find Full Text PDF

Aim: Local excision (LE) for T1 rectal cancer may be recommended in those with low-risk disease, while resection is typically recommended in those with a high risk of luminal recurrence or lymph node metastasis. The aim of this work was to compare survival between resection and LE.

Method: This was a population-based retrospective cohort study set in the Canadian province of Ontario.

View Article and Find Full Text PDF

When I use a word . . . Medical anniversaries in 2025.

BMJ

January 2025

Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

View Article and Find Full Text PDF

Peer reviewers' conflicts of interest in biomedical research: scoping review.

BMJ Evid Based Med

January 2025

Cochrane Denmark & Centre for Evidence-Based Medicine Odense (CEBMO), Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Background: Peer review may improve the quality of research manuscripts and aid in editorial decisions, but reviewers can have conflicts of interest that impact on their recommendations.

Objectives: The objective was to systematically map and describe the extent and nature of empirical research on peer reviewers' conflicts of interest in biomedical research.

Design: Scoping review METHODS: In this scoping review, we included studies investigating peer reviewers' conflicts of interest in journal manuscripts, theses and dissertations, conference abstracts, funding applications and clinical guidelines.

View Article and Find Full Text PDF

Objective: This study presents the personal experience of a 19-year-old student who fled the war in Ukraine, journeyed across multiple countries, and ultimately enrolled in a university psychology program in Croatia.

Methods: A collaborative autoethnographic approach was employed to explore the student's experience as a war refugee, traversing Europe, and beginning university life in a foreign country. Data were collected through the student's reflective writing.

View Article and Find Full Text PDF

Integrating environmental outcomes in randomised clinical trials: a call to action.

Lancet

December 2024

Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Tagensvej 22, DK-2200 Copenhagen, Denmark; Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

View Article and Find Full Text PDF

When I use a word . . . Academic integrity-principles and definitions.

BMJ

December 2024

Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

View Article and Find Full Text PDF

Aims: Acute promyelocytic leukemia (APL) progresses quickly and often leads to early hemorrhagic death. Treatment with all-trans retinoic acid (ATRA) promotes differentiation of APL cells and clinical remission, making APL a potentially curable malignancy. Understanding how ATRA works may lead to new treatments for other types of leukemia.

View Article and Find Full Text PDF

Background: Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic, recurrent, and inflammatory disease. HS is fairly rare among the population. This study was a part of the Global Hidradenitis Suppurativa Atlas (GHiSA) initiative, aiming to establish the prevalence of HS, based on a questionnaire and subsequent clinical examination targeting healthy adults accompanying patients undergoing care in a tertiary hospital.

View Article and Find Full Text PDF

Background: Systematic reviews within the field of animal research are becoming more common. However, in animal translational research, issues related to methodological quality and quality of reporting continue to arise, potentially leading to underestimation or overestimation of the effects of interventions or prevent studies from being replicated. The various tools and checklists available to ensure good-quality studies and proper reporting include both unique and/or overlapping items and/or simply lack necessary elements or are too situational to certain conditions or diseases.

View Article and Find Full Text PDF

Background: Multiple studies have shown that children with developmental disabilities (CDD) often live with unrecognized and untreated pain, consume inadequate diet and have inadequate levels of physical activity. This study aimed to analyze pain, dietary habits and physical activity of CDD in Croatia, North Macedonia and Serbia.

Methods: A cross-sectional study was conducted in Croatia, North Macedonia and Serbia in March-April 2023 within the Erasmus+ SynergyEd project.

View Article and Find Full Text PDF

Use of Single-Arm Observational Data for Causal Inference: The Case of GLA:D for Hip and Knee Osteoarthritis.

J Rheumatol

December 2024

Robin Christensen, MSc, PhD, Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark; Cochrane Denmark & Centre for Evidence-Based Medicine Odense (CEBMO), Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

View Article and Find Full Text PDF

Delayed publication of systematic reviews increases the risk of presenting outdated data. To date, no studies have examined the time and review process from title registration and protocol publication to the final publication of Campbell systematic reviews. This study aims to examine the publication time from protocol to full review publication and the time gap between database searches and full review publication for Campbell systematic reviews.

View Article and Find Full Text PDF

When I use a word . . . Academic integrity-defining misdemeanours.

BMJ

December 2024

Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

View Article and Find Full Text PDF

Treatment for women with postpartum iron deficiency anaemia.

Cochrane Database Syst Rev

December 2024

Cochrane Denmark and Centre for Evidence-Based Medicine Odense (CEBMO), University of Southern Denmark, Odense, Denmark.

Rationale: Postpartum iron deficiency anaemia is caused by antenatal iron deficiency or excessive blood loss at delivery and might affect up to 50% of labouring women in low- and middle-income countries. Effective and safe treatment during early motherhood is important for maternal well-being and newborn care. Treatment options include oral iron supplementation, intravenous iron, erythropoietin, and red blood cell transfusion.

View Article and Find Full Text PDF

When I use a word . . . Academic felonies and misdemeanours-adverse effects.

BMJ

December 2024

Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

View Article and Find Full Text PDF

Background: Pain is the leading cause of disability and reduced quality of life worldwide. Despite the increasing burden for patients and healthcare systems, pain research remains underfunded and under focused. Having stakeholders identify and prioritize areas that need urgent attention in the field will help focus funding topics, reduce 'research waste', improve the effectiveness of pain research and therapy and promote the uptake of research evidence.

View Article and Find Full Text PDF
Article Synopsis
  • There is a need for more research on neonatal behavior that applies to diverse global populations, but few appropriate assessment measures exist for use from birth.
  • The Neonatal Behavioural Assessment Scale (NBAS) was piloted in rural Gambia and showed great utility, leading to adaptations tailored to the local environment.
  • When comparing NBAS results between infants in the UK and The Gambia, findings indicated fewer state changes in Gambian infants and revealed associations with perinatal factors like pregnancy anxiety, suggesting cultural contexts impact early neurobehavioral development.
View Article and Find Full Text PDF

When I use a word . . . Academic fraud-plagiarism.

BMJ

November 2024

Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

View Article and Find Full Text PDF

Enhancing the trustworthiness of pain research: A call to action.

J Pain

November 2024

Dept of Clinical, Educational & Health Psychology, University College London, UK.

Article Synopsis
  • * Critical issues in research include poor governance, lack of diversity, inadequate stakeholder engagement, and issues with data transparency and reporting, which can lead to misguided clinical practices and low value care.
  • * The article proposes the ENTRUST-PE framework to enhance the reliability of pain research, aiming to build trust among stakeholders and calling for collective action to improve the quality and outcomes of pain science.
View Article and Find Full Text PDF

When I use a word . . . Academic fraud-the Darsee Affair.

BMJ

November 2024

Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

View Article and Find Full Text PDF