1,327 results match your criteria: "Centre for Cognitive Neuroscience[Affiliation]"

Pronouns create cohesive links in discourse by referring to previously mentioned elements. Here, we focus on pronominalization during speech production in three experiments employing ERP and fMRI methodologies. Participants were asked to produce two short sentences describing a man or woman using an object.

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Myoclonus After Cardiac Arrest: Need for Standardization-A Systematic Review and Research Proposal on Terminology.

Crit Care Med

November 2024

Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Member of the European Reference Network EpiCARE, Salzburg, Austria.

Objectives: Although myoclonus less than or equal to 72 hours after cardiac arrest (CA) is often viewed as a single entity, there is considerable heterogeneity in its clinical and electrophysiology characteristics, and its strength of association with outcome. We reviewed definitions, electroencephalogram, and outcome of myoclonus post-CA to assess the need for consensus and the potential role of electroencephalogram for further research.

Data Sources: PubMed, Embase, and Cochrane databases.

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Experimental design in language cognition research often involves presenting language material while measuring associated behavior and/or neural activity. To make the collected data easily and fully analyzable by both the original data authors and others, it is important to have detailed information about the stimulus presentation events, including the nature and properties of the presented stimuli, using a common vocabulary and syntax. We present HED LANG, a library extension of the Hierarchical Event Descriptors (HED) event annotation schema for time series behavioral and neuroimaging data.

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Mortality of chronic disorders of consciousness in adults and adolescents - a retrospective community based study from Salzburg, Austria.

Front Neurol

December 2024

Department of Neurology, Neurological Intensive Care and Neurorehabilitation, Christian Doppler Medical Centre, Centre for Cognitive Neuroscience Salzburg, Member of the European Reference Network EpiCARE, Paracelsus Medical University, Salzburg, Austria.

Introduction: Epidemiological data on disorders of consciousness (DoC) is rare and very heterogeneous due to difficulties in case ascertainment and differences in health care pathways between countries. This study reports data on mortality and survival time for DoC patients in Salzburg, Austria.

Methods: All patients with DoC were registered in the health care region of Salzburg North, Austria between 2007 and 2022 and their death data retrieved from the Statistik Austria.

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Cerebrospinal Fluid Cytology in Lyme Neuroborreliosis Revisited-Role of Neutrophilic Granulocytes: A Retrospective Single-Center Study.

J Clin Med

December 2024

Department of Neurology, Christian-Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, Ignaz Harrer Str. 79, 5020 Salzburg, Austria.

: diagnosis of Lyme neuroborreliosis (LNB) relies on medical history, clinical findings, and detection of pathogen-specific antibodies in the blood and cerebrospinal fluid (CSF). The chemoattractant CXCL13 serves as an additional marker for LNB acuity. During the diagnostic workup, cytomorphological examination of immune cells in CSF provides early insights.

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The effects of word frequency and predictability are informative with respect to bottom-up and top-down mechanisms during reading. Word frequency is assumed to index bottom-up, whereas word predictability top-down information. Findings regarding potential interactive effects, however, are inconclusive.

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Stress and the City: Mental Health in Urbanized vs. Rural Areas in Salzburg, Austria.

Int J Environ Res Public Health

October 2024

Department of Neurology, Neurointensive Care and Neurorehabilitation, European Reference Network EpiCARE, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.

Background: Living in the city is associated with a higher risk of suffering from stress, anxiety, and depression. Due to an increase of migration to the city, the association between mental health and city life is highly relevant to society.

Methods: We analyzed data of 9573 participants (Ø 55.

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There has been an increasing interest in identifying the biological underpinnings of human time perception, for which purpose research in non-human primates (NHP) is common. Although previous work, based on behaviour, suggests that similar mechanisms support time perception across species, the neural correlates of time estimation in humans and NHP have not been directly compared. In this study, we assess whether brain evoked responses during a time categorization task are similar across species.

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The sensory input, not the motor output, defines blink reflex conditioning.

Clin Neurophysiol

December 2024

Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Italy; Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria. Electronic address:

Objective: Blink reflexes following supraorbital nerve (SON) stimulation are typically modulated by conditioning stimuli (CS) to the index finger (D2) (low-intensity, prepulse inhibition paradigm) or SON (same intensity, paired-pulse paradigm). We aimed to disentangle whether CS-intensity or CS-induced motor responses define blink reflex modulation.

Methods: In 35 subjects, test SON stimuli (8 times sensory threshold, 8 × ST) were applied either alone or following CS.

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Article Synopsis
  • Lipid-containing vacuoles in microglia have been associated with neurodegenerative disorders for over a century, and recent studies show altered lipid metabolism in these conditions.
  • Research focused on how lipid-enriched nanoparticles affect microglia, revealing that these nanoparticles lead to vacuolization and the formation of Gitterzellen, a distinct microglia phenotype seen in Alzheimer's disease.
  • The study suggests that lipid-nanoparticles trigger this process through specific pathways, providing a valuable in vitro model to investigate the long-term effects of neurodegeneration.
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Article Synopsis
  • The 2023 American Epilepsy Society Annual Course focused on the importance of timing in evaluating and treating epilepsy, especially for vulnerable populations and those facing health disparities.
  • The course covered a wide range of topics, including gaps in epilepsy care, behavioral health optimization, seizure forecasting, and treatment timing for various seizure types and conditions.
  • Key discussions included the role of neuromodulation versus surgery, strategies for autoimmune-associated epilepsy, dietary therapy, and leveraging new biomarkers in collaboration with neuropsychological outcomes.
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Rescaling perceptual hand maps by visual-tactile recalibration.

Eur J Neurosci

November 2024

Cognitive Psychology, Department of Psychology, University of Salzburg, Salzburg, Austria.

After concurrent visual and tactile stimuli have been presented repeatedly with a spatial offset, unisensory tactile stimuli, too, are perceived with a spatial bias towards the previously presented visual stimuli. This so-called visual-tactile ventriloquism aftereffect reflects crossmodal recalibration. As touch is intrinsically linked to body parts, we asked here whether recalibration occurs at the level of individual stimuli or at a higher, integrated, map-like level.

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Background: The social environment is important to consider for effective promotion of movement behaviors like increased physical activity (PA) and reduced sedentary behavior (SB); yet, it is less often considered than individual and built environments. One way to advance social environment research is to develop system maps, an innovative, participatory, action-oriented research process that actively engages stakeholders to visualize system structures and explore how systems "work." The purpose of this research was to develop PA and SB system maps of the social environment embedded within the core/nuclear family system.

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Article Synopsis
  • The Global Burden of Disease Study (GBD) provides estimates for prevalence of idiopathic and secondary epilepsy but lacks detailed prevalence by the specific underlying causes of secondary epilepsy.
  • Using demographic data from Denmark, researchers identified causes of epilepsy to compare local prevalence rates with GBD 2019 data, analyzing hospital diagnoses and prescription records from 2009 to 2018.
  • Results showed that Denmark has a total epilepsy prevalence of 697 per 100,000, with significant underlying causes for secondary epilepsy including perinatal conditions, traumatic brain injury, brain tumors, and stroke, suggesting a need for future studies to address all forms of epilepsy more comprehensively.
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Progestagens and progesterone receptor modulation: Effects on the brain, mood, stress, and cognition in females.

Front Neuroendocrinol

November 2024

Department of Women's and Children's Health, Science for Life Laboratory, Uppsala University, Sweden. Electronic address:

Article Synopsis
  • - Progesterone, a lipophilic hormone, has significant effects on female behavior and mental health, particularly through its interaction with brain receptors, especially during key life stages like puberty and menopause.
  • - Research indicates that progesterone influences mood regulation, stress response, and cognitive processing, with potential improvements in conditions like premenstrual dysphoric disorder through its modulation of brain activity.
  • - The effects of progestins in contraceptives and hormone therapy on brain function and health outcomes (like stroke protection) are not fully understood, and more studies are needed to clarify how different factors (like dosage and timing) impact these effects.
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The approach-avoidance task (AAT) probes tendencies contributing to unwanted behaviours, like excessive snacking, by measuring RT differences between approach and avoidance responses to different stimuli. It retrains such tendencies using repeated avoidance of appetitive stimuli and approach of healthy alternatives. The most common paradigm, the irrelevant-feature AAT, conceals these stimulus-response contingencies by requiring approach or avoidance based on features irrelevant to the tendencies (e.

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Brain damage caused by status epilepticus: A prospective MRI study.

Epilepsy Behav

December 2024

Department of Neurology, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Member of the European Reference Network EpiCARE, Paracelsus Medical University of Salzburg, Austria; Neuroscience Institute, Christian Doppler University Hospital, Salzburg, Austria. Electronic address:

Background: Status epilepticus (SE) is a severe neurological condition that might lead to long-term consequences such as neuronal death. This study investigated whether SE leads to brain volume loss by characterizing the dynamic of peri-ictal MRI abnormalities (PMA) through follow-up MRIs and assessing whether SE duration and specific outcome characteristics are associated with brain atrophy.

Methods: A prospective single-center cohort study enrolled 590 adult patients with definitive or possible SE.

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Background: The association between education and atherosclerotic cardiovascular disease (ASCVD) has been well described for decades. Nevertheless, most cardiovascular risk models, including SCORE2, still do not take educational status into account even if this factor is easily assessed and costs nothing to acquire. Using carotid plaques as a proxy for ASCVD, we analysed educational status as associated with carotid plaque development, to determine if the relationship remains, how it relates to traditional risk factors and, how it impacts the European cardiovascular risk model, SCORE2.

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Objectives: Parkinson's disease psychosis (PDP) is a prevalent non-motor symptom associated with Parkinson's disease. The treatment options for PDP are limited, and its pharmacological management remains ambiguous. This study aimed to evaluate the existing evidence in relation to clinical practice.

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While it has become standard practice to report the reliability of self-report scales, it remains uncommon to do the same for experimental paradigms. To facilitate this practice, we review old and new ways to compute reliability in reaction-time tasks, and we compare their accuracy using a simulation study. Highly inaccurate and negatively biased reliability estimates are obtained through the common practice of averaging sets of trials and submitting them to Cronbach's alpha.

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The tendency to approach food faster than to avoid it (i.e., approach bias) is thought to facilitate food intake, particularly foods that conflict with one's dietary goals.

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Chronic tinnitus is associated with aging but not dementia.

Hear Res

November 2024

Centre for Cognitive Neuroscience and Department of Psychology, Paris-Lodron-University Salzburg, Salzburg, Austria; Neuroscience Institute, Christian Doppler University Hospital, Paracelsus Medical, University, Salzburg, Austria.

Aim: Aging is related to deterioration of bodily and neural functions, leading to various disorders and symptoms, including the development of dementia, hearing loss, or tinnitus. Understanding how these phenomena are intertwined and how aging affects those is crucial for prevention and the future development of interventions.

Methods: We utilized the UK Biobank which includes a total of 502,382 participants between 40 and 70 years old.

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Background: Encephalitis originates from diverse autoimmune and infectious etiologies. Diagnostic challenges arise due to the spectrum of presentation and the frequent absence of specific biomarkers. This study aimed to comprehensively characterize and differentiate autoimmune encephalitis (AE) from infectious encephalitis (IE) in adults, and disentangle clinical, paraclinical, and therapeutic differences.

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Efficacy and safety of stiripentol in the prevention and cessation of status epilepticus: A systematic review.

Epilepsia Open

December 2024

Department of Neurology, Christian-Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Member of ERN EpiCARE, Salzburg, Austria.

Article Synopsis
  • Status epilepticus (SE) is a severe medical emergency that requires rapid treatment, especially in people with epilepsy, to reduce risks of long-term health issues and death.
  • Stiripentol is an approved antiseizure medication for Dravet syndrome that has been studied for its effectiveness in lowering the incidence of SE in patients with this condition and other types of epilepsy.
  • Analysis of 17 studies suggests that stiripentol, often used alongside other medications, significantly reduces SE episodes, with many patients experiencing a drop in frequency or becoming free of SE, and it appears to be well-tolerated.
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Fear of negative (FNE) and positive (FPE) evaluation constitute distinct components of social anxiety and relate to altered affectivity. It is unclear whether individuals with strong FNE/FPE overreact to social stressors only or to more unspecific ones as well. The present set of three studies (n = 109 and n = 97 healthy individuals in study 1/2, n = 49 patients with social anxiety disorder in study 3) assessed whether reactivity to various daily stressors and non-specific momentary stress/emotions assessed through ecological momentary assessment depend on individuals' level of FPE/FNE.

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