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Centre for Clinical Veterinary Medicine... Publications | LitMetric

488 results match your criteria: "Centre for Clinical Veterinary Medicine[Affiliation]"

Risk factors for omphalitis in neonatal dairy calves.

Front Vet Sci

November 2024

Division for Ruminants and Camelids, Unit for Internal Medicine and Surgery, Department of Veterinary Medicine, Farm Animal Clinic, Freie Universität Berlin, Berlin, Germany.

Knowledge about potential risk factors for animal health is crucial to achieve animal welfare. The aim of this study was to provide practical guidance for farmers to improve the health status of their youngstock by identifying and eliminating risk factors for omphalitis in neonatal calves. A cross-sectional study including 3,445 dairy calves from 567 farms located in three structurally different regions of Germany was performed from December 2016 to July 2019.

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Correlation of Anti-Müllerian hormone serum concentration measured in proestrus and estrus with the litter size as a fertility marker in bitches.

Domest Anim Endocrinol

November 2024

Clinic of Small Animal Surgery and Reproduction at the Centre for Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Veterinaerstr. 13, 80539 Munich, Germany. Electronic address:

The use of the anti-Müllerian hormone (AMH) serum concentration as a fertility marker has been shown in cows, sheep and mares and has been indicated in one study in female dogs. The aim of this study was to investigate the connection between the AMH serum concentration, taken at two defined time points during the bitch`s heat, and the litter size to investigate whether AMH can be used as a practical measurement for the individual breeding bitch to predict litter size. The study was carried out on 27 healthy female dogs presented for pre-breeding examination, considering all previously known influencing factors on AMH in the bitch such as age, body weight and estrous cycle phase at the time the sample was taken.

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Complement Evasion Protects FCoV from Virus Clearance Within Prototypic FIP Lesions.

Viruses

October 2024

Section of Clinical and Comparative Neuropathology, Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany.

Feline infectious peritonitis (FIP) is a fatal disease in cats caused by infection with feline coronavirus (FCoV). Despite severe inflammatory changes, defense mechanisms fail to achieve virus clearance. Some studies focused on various immune evasion mechanisms, but none of these studies elucidated the inefficacy of the complement system, which is one major player in FIP-associated immune pathogenesis.

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Effect of stabilizers on the detection of swine influenza A virus (swIAV) in spiked oral fluids over time.

Porcine Health Manag

November 2024

Clinic for Swine at the Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Oberschleißheim, Germany.

Background: Aggregated samples such as oral fluids (OFs) display an animal friendly and time and cost-efficient sample type for swine Influenza A virus (swIAV) monitoring. However, further molecular and biological characterization of swIAV is of particular significance. The reportedly inferior suitability of aggregated samples for subtyping of swIAV presents a major drawback compared to nasal swabs, still considered the most appropriate sample type for this purpose (Garrido-Mantilla et al.

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Circulation of West Nile virus and Usutu virus in birds in Germany, 2021 and 2022.

Infect Dis (Lond)

November 2024

Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

Background: Usutu virus (USUV) and West Nile virus (WNV) are zoonotic arthropod-borne orthoflaviviruses. The enzootic transmission cycles of both include mosquitoes as vectors and birds as amplifying hosts. For more than 10 years, these viruses have been monitored in birds in Germany by a multidisciplinary network.

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A 24/7 AI sound-based coughing monitoring system was applied in combination with oral fluids (OFs) and bioaerosol (AS)-based screening for respiratory pathogens in a conventional pig nursery. The objective was to assess the additional value of the AI to identify disease patterns in association with molecular diagnostics to gain information on the etiology of respiratory distress in a multimicrobially infected pig population. Respiratory distress was measured 24/7 by the AI and compared to human observations.

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Balance Assessment on a Modified Posturomed Platform in Healthy Dogs.

Vet Sci

October 2024

LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University Munich, 80539 Munich, Germany.

Reliable, standardized balance tests for dogs are not available yet. The purpose of this study was to investigate the reliability of static and dynamic posturography in healthy dogs. Healthy dogs ( = 20) were positioned with four paws longitudinally and with the forepaws only transversely on a modified pressure-sensitive balance platform (Posturomed-FDM-JS, Zebris, Isny, Germany).

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Article Synopsis
  • * Affected dogs exhibited significant brain degeneration and the presence of harmful autofluorescent materials in their neurons, which contributed to a preliminary diagnosis of NCL.
  • * Genetic analysis identified an 18,819 base pair duplication in the MFSD8 gene in both dogs, which is linked to NCL in humans and other mammals, confirming the diagnosis as NCL7 and enabling future genetic testing to prevent breeding carriers.
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Allergen immunotherapy using recombinant allergens improves clinical signs of equine insect bite hypersensitivity.

Front Allergy

September 2024

Clinical Immunology Group, Division of Neurological Sciences, Department of Clinical Research-VPH, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Introduction: Insect bite hypersensitivity (IBH) is an IgE-mediated allergic dermatitis of horses caused by bites of spp., sharing some common features with human atopic dermatitis. Allergen immunotherapy (AIT) using whole-body extracts has limited efficacy.

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Immune Response after Vaccination against Tick-Borne Encephalitis Virus (TBEV) in Horses.

Vaccines (Basel)

September 2024

Clinic for Equine Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.

Article Synopsis
  • Horses can develop infections from the tick-borne encephalitis virus (TBEV), but there is currently no vaccine specifically for horses, unlike humans.
  • In a study with seven healthy horses, four received a human TBEV vaccine while three were controls; blood samples were collected to analyze immune responses over time.
  • Results showed no adverse effects in horses from the vaccine and a significant increase in TBEV-specific IgG antibodies and neutralizing antibody titres after the second vaccination, although IgM levels did not show a significant increase overall.
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Performance of the Vetscan Imagyst in point-of-care detection of in canine fecal samples.

J Vet Diagn Invest

September 2024

Small Animal Clinic, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany.

is a common parasite of the gastrointestinal tract of dogs, with an especially high prevalence in dogs <1-y-old. Methods for detecting are point-of-care (POC) tests such as lateral-flow tests or fecal flotation. The Vetscan Imagyst (Zoetis) is a new POC device for the detection of in fecal samples using zinc sulfate flotation, automated slide scanning, and image recognition with artificial intelligence.

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Physiological Anti-Müllerian Hormone Concentrations in Male and Female Dogs and Cats before and around Puberty.

Animals (Basel)

September 2024

Small Animals Clinic, Centre for Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Veterinaerstr. 13, 80539 Munich, Germany.

In recent years several studies established the diagnostic value of anti-Müllerian hormone (AMH) in companion animals. However, less is known about physiological AMH concentrations in young individuals highlighting the necessity to apply the diagnostic findings to this group. The aim of this study was to determine the AMH values of healthy male and female dogs between the age of 8 and 48 weeks, tomcats under 8 weeks and up to 48 weeks of age and queens between 2 to 12 weeks of age.

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Pathologic Changes in and Immunophenotyping of Polymyositis in the Dutch Kooiker Dog.

Animals (Basel)

August 2024

Expertise Centre of Genetics, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands.

Earlier, we described a breed-specific inflammatory myopathy in Dutch Kooiker dogs (Het Nederlandse Kooikerhondje), one of the nine Dutch breeds. The disease commonly manifests itself with clinical signs of difficulty walking, muscle weakness, exercise intolerance, and/or dysphagia. In nearly all dogs' creatine kinase (CK) activity was elevated.

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The objective of this study was to investigate the distribution of mastitis pathogens in quarter milk samples (QMSs) submitted to the laboratory of the Bavarian Animal Health Service (TGD) between 2014 and 2023 in general, in relation to the clinical status of the quarters, and to analyze seasonal differences in the detection risk. Each QMS sent to the TGD during this period was analyzed and tested using the California Mastitis Test (CMT). Depending on the result, QMSs were classified as CMT-negative, subclinical, or clinical if the milk character showed abnormalities.

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Borna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon). The known BoDV-1-endemic area is remarkably restricted to parts of Germany, Austria, Switzerland and Liechtenstein. To gain comprehensive data on its occurrence, we analysed diagnostic material from suspected BoDV-1-induced encephalitis cases based on clinical and/or histopathological diagnosis.

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Infections with () in cats seem to be rare. The study aimed to determine whether infections in cats are underestimated and to identify the risk factors for infection. Blood samples of 1015 cats across Europe (2017-2022), sent to IDEXX Laboratories, Germany, were tested for DNA.

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Article Synopsis
  • Lokivetmab is a special medicine for dogs that helps stop itching caused by a skin problem called canine atopic dermatitis (cAD).
  • In a study with 150 dogs, it worked well in 77% of the cases and the longer dogs got treated, the better it worked.
  • There were a few side effects in 8% of dogs, like feeling tired or having stomach issues, but overall, it was safe for long-term use.
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Barometric whole-body plethysmography (BWBP) is considered to be a particularly gentle method of assessing lung function in cats. However, there have been no studies to date investigating the stress experienced by cats during measurements. The prospective study included 48 healthy adult cats.

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Background: Goniometry can be performed clinically in dogs with cranial cruciate ligament disease (CCLD). The purpose of this study was (1) to compare reliability of stifle goniometry in dogs with CCLD and healthy dogs and (2) to investigate the effect of compliance on measurements. Dogs presented for surgical intervention for CCLD (CCL-Dogs; n = 15) and orthopedically healthy dogs (C-Dogs; n = 11) were enrolled in this prospective randomized controlled trial.

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In the past, feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) was considered fatal. Today, highly efficient drugs, such as GS-441524, can lead to complete remission. The currently recommended treatment duration in the veterinary literature is 84 days.

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Hemotrophic Mycoplasmas-Vector Transmission in Livestock.

Microorganisms

June 2024

Department of Livestock Infectiology and Environmental Hygiene, Institute of Animal Science, University of Hohenheim, 70593 Stuttgart, Germany.

Hemotrophic mycoplasmas (HMs) are highly host-adapted and specialized pathogens infecting a wide range of mammals including farm animals, i.e., pigs, cattle, sheep, and goats.

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Haemotrophic mycoplasmas (haemoplasmas) are a group of highly specific and adapted bacteria. Three different haemoplasma species in pigs are known to date: (.) , and ' (.

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An 8-year-old rabbit presented with a 5-day history of acute difficulty in walking. Neurological examination revealed tetraparesis, proprioceptive deficits in both pelvic limbs and the right thoracic limb, decreased withdrawal reflex on the right thoracic limb and hyperreflexia in the pelvic limbs. A cervico-thoracic (C6-T2) localization was suspected.

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Background: Early diagnosis of neosporosis in dogs is challenging.

Objectives: To evaluate the feasibility of a compound multimodal testing approach for diagnosing in dogs neuromuscular and combined forms of neosporosis.

Animals: A total of 16 dogs diagnosed with solely neuromuscular neosporosis or with a combination of neuromuscular and central nervous system neosporosis.

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Article Synopsis
  • Flow cytometry is an important tool for monitoring immune responses in both humans and animals, including cats, but requires prompt processing of blood samples for accurate analysis.
  • The SMART Tube system enables long-term storage of whole blood samples at -80°C, but had only been used for human samples until now.
  • A new protocol for flow cytometry using SMART Tubes has been developed for feline blood samples, allowing analysis of various immune cells up to 2 years after collection, thereby enhancing veterinary research possibilities.
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