Fluorene intercalated graphene oxide based CoQ10 imprinted polymer composite as a selective platform for electrochemical sensing of CoQ10.

The new objective of sustainable analytical chemistry is to develop validated robust, swift, simple and highly sensitive analytical methods that are based on cost effective sensing technology. Therefore, in this study the electro-chemical detection of coenzyme Q10 (CoQ10) was achieved using a fluorene intercalated graphene oxide based CoQ10 imprinted polymer composite modified glassy carbon electrode (CoQ10-IGOPC/GCE). The synthesized sensing material was characterized using SEM, XRD and FT-IR to determine the morphology and functional properties.

Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP.

The emergence of methicillin-resistant Staphylococcus aureus isolates highlights the urgent need to develop more antibiotics. ClpP is a highly conserved protease regulated by ATPases in bacteria and in mitochondria. Aberrant activation of  bacterial ClpP is an alternative method of discovering antibiotics, while it remains difficult to develop selective  Staphylococcus aureus ClpP activators that can avoid disturbing Homo sapiens ClpP functions.

Fluoro-cotton assisted non-targeted screening of organic fluorine compounds from rice (Oryza sativa L.) grown in perfluoroalkyl substance polluted soil.

The toxicity and environmental persistence of perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS) are of great concern for food intake in humans. However, PFASs conversion or conjugation to other substances in rice grown on PFASs polluted soil has not been explored clearly. These unknown transformed or conjugated products of PFOA and PFOS could be harmful to human health.

Synthetic star shaped tetra-tailed biocompatible supramolecular amphiphile as an efficient nanocarrier for Amphotericin B.

Macrocycle-based amphiphiles are capable of self-assembling into multidimensional nano-architecture with defined dimensions for various applications. Herein we report the synthesis, physio-chemical characterizations and oral drug delivery profiling of resorcinarene-based amphiphilic supramolecular macrocycle. The macrocycle was synthesized in two-step reaction and characterized using H NMR, Mass spectrometry and IR spectroscopic techniques.

Surface-Oxidised Carbon Nanofibre-Based Nanofluids: Structural, Morphological, Stability and Thermal Properties.

The reputation of nanofluids as a convenient heat transfer media has grown in recent years. The synthesis of nanofluids is often challenging, particularly carbon-based nanofluids, due to the rapid agglomeration of the nanoparticles and the instability of the nanofluids. In this regard, surface modification and surfactant addition are potential approaches to improve the physical and thermal properties of carbon-based nanofluids that have been studied and the structural, morphological, and thermal characteristics of surface-oxidised carbon nanofibre (CNF)-based nanofluids has been characterised.

Transformations and antioxidative activities of lignans and stilbenes at high temperatures.

Thermal transformations of polyphenols from the lignan and stilbene families were investigated at temperatures ranging from 200 °C to 250 °C, in polyethylene glycol (PEG-400), dimethylformamide (DMF) and in sunflower oil (SO). The polyphenols showed varying degrees of thermal stabilities and in some cases intramolecular transformations were observed. The formed products were isolated and characterized.

The Frontiers of Functionalized Nanocellulose-Based Composites and Their Application as Chemical Sensors.

Chemical sensors are a rapidly developing technology that has received much attention in diverse industries such as military, medicine, environmental surveillance, automotive power and mobility, food manufacturing, infrastructure construction, product packaging and many more. The mass production of low-cost devices and components for use as chemical sensors is a major driving force for improvements in each of these industries. Recently, studies have found that using renewable and eco-friendly materials would be advantageous for both manufacturers and consumers.

Zinc Oxide Nanoconjugates against Brain-Eating Amoebae.

and are opportunistic protists, responsible for fatal central nervous system infections such as primary amoebic meningoencephalitis (PAM) and granulomatous amoebic encephalitis (GAE) with mortality rates higher than 90%. Threatening a rise in cases is the increase in temperature due to global warming. No effective treatment is currently available.

Nanocellulose-Based Nanocomposites for Sustainable Applications: A Review.

Nanocellulose has emerged in recent years as one of the most notable green materials available due to its numerous appealing factors, including its non-toxic nature, biodegradability, high aspect ratio, superior mechanical capabilities, remarkable optical properties, anisotropic shape, high mechanical strength, excellent biocompatibility and tailorable surface chemistry. It is proving to be a promising material in a range of applications pertinent to the material engineering to biomedical applications. In this review, recent advances in the preparation, modification, and emerging application of nanocellulose, especially cellulose nanocrystals (CNCs), are described and discussed based on the analysis of the latest investigations.

Application of Bacterial Endophytes to Control Bacterial Leaf Blight Disease and Promote Rice Growth.

Xanthomonas oryzae pv. oryzae (Xoo) causes bacterial leaf blight (BLB) disease in rice (Oryza sativa L.) and it is among the most destructive pathogen responsible for severe yield losses.

Greener synthesis of nanostructured iron oxide for medical and sustainable agro-environmental benefits.

Nanoscale iron oxide-based nanostructures are among the most apparent metallic nanostructures, having great potential and attracting substantial interest due to their unique superparamagnetic properties. The green production of nanostructures has received abundant attention and been actively explored recently because of their various beneficial applications and properties across different fields. The biosynthesis of the nanostructure using green technology by the manipulation of a wide variety of plant materials has been the focus because it is biocompatible, non-toxic, and does not include any harmful substances.

Novel family of nitrogen-rich energetic (1,2,4-triazolyl) furoxan salts with balanced performance.

Nitrogen-rich energetic materials comprised of a combination of several heterocyclic subunits retain their leading position in the field of materials science. In this regard, a preparation of novel high-energy materials with balanced set of physicochemical properties is highly desired. Herein, we report the synthesis of a new series of energetic salts incorporating a (1,2,4-triazolyl) furoxan core and complete evaluation of their energetic properties.

Genome sequence data of sp. CCB-MMP212 isolated from Malaysian mangrove: A potential strain in arsenic resistance with ArsI, C•As lyase.

 sp. CCB-MMP212 is a Gram-positive bacterium isolated from mangrove sediment in Matang Perak, Malaysia (4.85496°E, 100.

Identifying Leptospira interrogans putative virulence factors with a yeast protein expression screen.

Leptospirosis is a zoonotic disease caused by pathogenic Leptospira spp., with global implications primarily in tropical countries. However, the mechanisms of leptospiral pathogenesis are still not fully known and not all virulence factors (VFs) have been identified.

Fiber-Reinforced Polymer Nanocomposites.

"Fiber-Reinforced Polymer Nanocomposites" is a newly open Special Issue of , which aims to publish original and review papers on new scientific and applied research and make boundless contributions to the finding and understanding of the reinforcing effects of various nanomaterials on the performance of polymer nanocomposites [...

Multi-Class Cancer Subtyping in Salivary Gland Carcinomas with MALDI Imaging and Deep Learning.

Salivary gland carcinomas (SGC) are a heterogeneous group of tumors. The prognosis varies strongly according to its type, and even the distinction between benign and malign tumor is challenging. Adenoid cystic carcinoma (AdCy) is one subgroup of SGCs that is prone to late metastasis.

Comparative Genomic Analyses of the Genus Illuminate Biosynthetic Gene Clusters Associated with Antagonism.

The genus is known for its ecophysiological versatility encompassing free-living, symbiotic, and pathogenic lifestyles. sp. CCB-ST2H9 was isolated from estuarine sediment collected at Matang Mangrove, Malaysia.

Renaissance of dinitroazetidine: novel hybrid energetic boosters and oxidizers.

Nitrogen-oxygen organic materials constitute an important family of multipurpose high-energy materials. However, the preparation of energetic boosters and oxidizers for various civil and space technologies remains a challenging task and such materials usually require special precautions and fine tunability of their functional properties. To find a balance between energy and safety while retaining the oxidizing ability of target energetic materials, novel hybrid organic compounds comprising furoxan and 3,3-dinitroazetidine scaffolds enriched with additional nitro groups were synthesized.

Mechanistic insights into global suppressors of protein folding defects.

Most amino acid substitutions in a protein either lead to partial loss-of-function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue defects caused by diverse loss-of-function mutations. Such global suppressor mutations are key drivers of protein evolution.

Fine sand facilitates egg extrusion and improves reproductive output in female mud crab genus .

Mud crabs (genus ) are gaining attention as potential aquaculture species due to their lucrative market price and high demand. One of the essential components of mud crab culture is broodstock quality. The optimisation of mud crab broodstock culture currently focused on its nutritional aspects and common rearing parameters, including stocking density and temperature.

RelEB3 toxin-antitoxin system of Salmonella Typhimurium with a ribosome-independent toxin and a mutated non-neutralising antitoxin.

The RelEB3 toxin-antitoxin (TA) system of Salmonella enterica subsp. enterica serovar Typhimurium consists of a RelE3 toxin which suppresses bacterial growth, but its RelB3 antitoxin does not neutralise the toxin. The relEB3 operon is widespread in Proteobacteria and is related to higBA2 from Vibrio cholerae.

Impact of Hybrid Fillers on the Properties of High Density Polyethylene Based Composites.

The main objective of this work is to develop a variety of hybrid high-density polyethylene (HDPE) micro- and nanocomposites and to investigate their thermal, mechanical, and morphological characteristics as a function of number of fillers and their contents percentage. In this study, 21 formulations of the composites were prepared using fillers with different sizes including micro fillers such as talc, calcium carbonate (CaCO), as well as nano-filler (fumed silica (FS)) though the melt blending technique. The morphological, mechanical, and thermal properties of the composite samples were evaluated.

Total and Chemoenzymatic Synthesis of Seongsanamide E.

The total and chemoenzymatic synthesis of the depsipeptide natural product seongsanamide E, , is described. The synthetic C-terminal -acetylcysteamine thioester of linear natural product was macrolactonized by the excised recombinant purified seongsanamide thioesterase (Sgd-TE) domain, generating . Sgd-TE also effects the ring opening of .

Design, Synthesis, Molecular Docking, ADMET, and Biological Studies of Some Novel 1,2,3-Triazole Linked Tetrazoles as Anticancer Agents.

Background: 1,2,3-Triazole-tetrazoles have received substantial attention because of their unique bioisosteric properties and an extraordinarily broad spectrum of biological activity, making them interesting for the drug design, and synthesis of a delightful class of widely investigated heterocyclic compounds. To address major health concerns, it is consequently important to devote ongoing effort to the identification and development of New Chemical Entities (NCEs) as possible anticancer medicines.

Methods: We began our initial investigation of the reaction between 5-(azidomethyl)-1H-pyrrolo[ 2,3-b]pyridine and 1-phenyl substituted-5-(prop-2-yn-1-ylthio)-1 H-tetrazole under click chemistry to give the corresponding triazole precursors and screened for their cytotoxicity reported by variations in therapeutic actions of the parent molecule.

The Impact of Polymer Electrolyte Properties on Lithium-Ion Batteries.

In recent decades, the enhancement of the properties of electrolytes and electrodes resulted in the development of efficient electrochemical energy storage devices. We herein reported the impact of the different polymer electrolytes in terms of physicochemical, thermal, electrical, and mechanical properties of lithium-ion batteries (LIBs). Since LIBs use many groups of electrolytes, such as liquid electrolytes, quasi-solid electrolytes, and solid electrolytes, the efficiency of the full device relies on the type of electrolyte used.