1 results match your criteria: "Centre for Biologics Evaluation and Research (CBER)[Affiliation]"
Femtogram Level Sensitivity achieved by Surface Engineered Silica Nanoparticles in the Early Detection of HIV Infection.
Sci Rep
August 2017
Laboratory of Molecular Virology, Centre for Biologics Evaluation and Research (CBER), US Food and Drug Administration, Bldg. 72, White Oak Campus, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
We have engineered streptavidin labelled Europium doped fluorescent silica nanoparticles which significantly increased sensitivity without compromising the specificity of the immunoassay. As a proof of concept, a time resolved fluorescence based sandwich immunoassay was developed to detect HIV-1 p24 antigen in clinical specimens. The detection range of the silica nanoparticle based immunoassay (SNIA) was found to be between 0.
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