7 results match your criteria: "Centre for Behavioural Science and Mental Health[Affiliation]"
Green space exposure and blood DNA methylation at birth and in childhood - A multi-cohort study.
Environ Int
June 2024
ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública, Spain.
Green space exposure has been associated with improved mental, physical and general health. However, the underlying biological mechanisms remain largely unknown. The aim of this study was to investigate the association between green space exposure and cord and child blood DNA methylation.
View Article and Find Full Text PDFCord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight.
Int J Obes (Lond)
July 2022
Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Torino, Italy.
Background: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight in childhood, mediated through cord blood metabolites. Additionally, rapid postnatal growth was considered a potential mediator on childhood overweight, alone and sequentially to each metabolite.
View Article and Find Full Text PDFCord blood metabolic signatures predictive of childhood overweight and rapid growth.
Int J Obes (Lond)
October 2021
Μedical Research Council Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Introduction: Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy and overweight in early childhood in four European birth cohorts.
Methods: Untargeted liquid chromatography-mass spectrometry metabolomic profiles were measured in cord blood from 399 newborns from four European cohorts (ENVIRONAGE, Rhea, INMA and Piccolipiu).
Selective reduction in the expression of type-1 metabotropic glutamate receptors in the hippocampus of adult rats born by caesarean section.
Int J Dev Neurosci
June 2021
Centre for Behavioural Science and Mental Health, Istituto Superiore di Sanita, Roma, Italy.
Perinatal hypoxia causes long-term neurobiological consequences, including alterations in mechanisms of activity-dependent synaptic plasticity and cognitive dysfunction. Changes in neurotransmitter receptors have been associated with these alterations, but little is known on how early hypoxia influences the expression and function of metabotropic glutamate (mGlu) receptors in adult life. This is an important issue because mGlu receptors are implicated in mechanisms of synaptic plasticity.
View Article and Find Full Text PDFChanges in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births.
PLoS Med
August 2020
The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands.
Article Synopsis
- Fetal smoke exposure is a significant and avoidable risk factor for complications during birth and can contribute to childhood obesity, with varying risks based on maternal and paternal smoking behavior.
- A comprehensive analysis was conducted involving 229,158 families from 28 cohorts across Europe and North America, examining how different patterns of smoking (quitting or reducing, and maternal vs. paternal smoking) affect birth outcomes.
- Results indicated that maternal smoking during the entire pregnancy increases the risks of preterm birth, small size for gestational age, and childhood overweight, while smoking only in the first trimester raised the risk of childhood overweight without adverse effects on birth outcomes.
Beneficial Effects of Fingolimod on Social Interaction, CNS and Peripheral Immune Response in the BTBR Mouse Model of Autism.
Neuroscience
May 2020
Centre for Behavioural Science and Mental Health, Istituto Superiore di Sanità, Rome, Italy. Electronic address:
Article Synopsis
- Autism Spectrum Disorders (ASD) are associated with difficulties in social communication and repetitive behaviors, and this study investigates the effects of the immunomodulator Fingolimod on a mouse model of ASD.
- Chronic treatment with Fingolimod for four weeks improved social interactions and increased the expression of important brain factors associated with neural health in BTBR mice, suggesting beneficial effects on neurodevelopmental challenges.
- The study highlights the drug's potential to normalize inflammatory markers in both the brain and gut of the ASD model, advocating for further research on immune mechanisms in ASD therapies.
Measuring Child Socio-Economic Position in Birth Cohort Research: The Development of a Novel Standardized Household Income Indicator.
Int J Environ Res Public Health
March 2020
Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, 10126 Torino, Italy.
Article Synopsis
- * The authors propose a new method called the "Equivalized Household Income Indicator (EHII)" to create a standardized income measure across different cohorts by utilizing existing data from European surveys.
- * Results show that EHII is strongly correlated with self-reported income and other socioeconomic factors, and it has an inverse relationship with child body mass index (BMI), suggesting potential for enhancing research on health inequalities in Europe.