6 results match your criteria: "Centre for Atherothrombotic and Metabolic Disease[Affiliation]"
Evaluating Trastuzumab in the treatment of HER2 positive breast cancer.
Histol Histopathol
October 2020
Centre for Atherothrombotic and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.
The transmembrane oncoprotein HER2 is encoded by ERBB2 gene and overexpressed in around 20% of invasive breast cancers. It can be specifically targeted by Trastuzumab (Herceptin®), a humanised IgG1 antibody. Trastuzumab has been regarded as one of the most effective therapeutic drugs targeted to HER2 positive cancers.
View Article and Find Full Text PDFThe effect of high-fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice.
J Anat
October 2019
School of Biological Sciences, University of Reading, Reading, UK.
Obesity is a worldwide nutritional disorder affecting body performance, including skeletal muscle. Inhibition of myostatin not only increases the muscle mass but also it reduces body fat accumulation. We examined the effect of high-fat diet on the phenotypic properties of forelimb muscles from myostatin null mice.
View Article and Find Full Text PDFCurrent Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports.
Int J Sports Med
July 2019
Hull York Medical School, Centre for Atherothrombotic and Metabolic Disease, Hull, United Kingdom of Great Britain and Northern Ireland.
Article Synopsis
- Platelet-based therapies are used in regenerative medicine and cosmetic treatments, particularly for accelerating healing after injuries through localized injections.
- Since 2011, the use of autologous platelet-rich plasma in sports is allowed by the World Anti-Doping Agency, though its effects on enhancing performance remain unproven.
- Recent research indicates that growth factors from platelets influence muscle and tissue regeneration, raising concerns about potential misuse in competitive sports, prompting the need for strategies to prevent doping.
Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease.
PLoS Negl Trop Dis
January 2019
School of Pharmacy, University of Reading, Reading, United Kingdom.
Snakebite is a major neglected tropical health issue that affects over 5 million people worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year. Snakebite envenomation also causes innumerable morbidities, specifically loss of limbs as a result of excessive tissue/muscle damage.
View Article and Find Full Text PDFPlatelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury.
Acta Physiol (Oxf)
March 2019
Molecular Physiology Laboratory, Centre for Atherothrombotic and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.
Aim: The use of platelets as biomaterials has gained intense research interest. However, the mechanisms regarding platelet-mediated skeletal myogenesis remain to be established. The aim of this study was to determine the role of platelet releasate in skeletal myogenesis and muscle stem cell fate in vitro and ex vivo respectively.
View Article and Find Full Text PDFDuchenne muscular dystrophy: genome editing gives new hope for treatment.
Postgrad Med J
May 2018
Molecular Physiology Laboratory, Centre for Atherothrombotic and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.
Duchenne muscular dystrophy (DMD) is a progressive wasting disease of skeletal and cardiac muscles, representing one of the most common recessive fatal inherited genetic diseases with 1:3500-1:5000 in yearly incidence. It is caused by mutations in the DMD gene that encodes the membrane-associated dystrophin protein. Over the years, many have been the approaches to management of DMD, but despite all efforts, no effective treatment has yet been discovered.
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