217 results match your criteria: "Centre de recherche en neurosciences de Lyon CRNL[Affiliation]"

Older adults show decline in visual search performance, but the underlying cause remains unclear. It has been suggested that older adults' altered performance may be related to reduced spatial attention to peripheral visual information compared with younger adults. In this study, 18 younger (M = 21.

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Three key questions to move towards a theoretical framework of visuospatial perspective taking.

Cognition

June 2024

Centre de Recherche en Neurosciences de Lyon CRNL, U1028, UMR5292, Trajectoires, F-69500 Bron, France; Centre Ressource de Réhabilitation Psychosociale, CH Le Vinatier, Lyon, France.

What would a theory of visuospatial perspective taking (VSPT) look like? Here, ten researchers in the field, many with different theoretical viewpoints and empirical approaches, present their consensus on the three big questions we need to answer in order to bring this theory (or these theories) closer.

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The mechanisms underlying atypical sensory processing in autism remain to be elucidated, but research points toward a role of the glutamatergic/GABAergic balance. To investigate the potential relationships between visual sensitivity and its molecular correlates in autism, we combined data from electroencephalography (EEG) and magnetic resonance spectroscopy (MRS) studies. Twenty autistic adults and sixteen neurotypical adults (NT) participated in both an EEG study assessing visual sensitivity (Sapey-Triomphe et al.

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Memory retrieval entails dynamic interactions between the medial temporal lobe and areas in the parietal and frontal cortices. Here, we tested the hypothesis that effective connectivity between the precuneus, in the medial parietal cortex, and the medial temporal cortex contributes to the subjective quality of remembering objects together with information about their rich spatio-temporal encoding context. During a 45 min encoding session, the participants were presented with pictures of objects while they actively explored a virtual town.

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We review the evidence for the conceptual association between arithmetic and space and quantify the effect size in meta-analyses. We focus on three effects: (a) the operational momentum effect (OME), which has been defined as participants' tendency to overestimate results of addition problems and underestimate results of subtraction problems; (b) the arithmetic cueing effect, in which arithmetic problems serve as spatial cues in target detection or temporal order judgment tasks; and (c) the associations between arithmetic and space observed with eye- and hand-tracking studies. The OME was consistently found in paradigms that provided the participants with numerical response alternatives.

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Resting network architecture of theta oscillations reflects hyper-learning of sensorimotor information in Gilles de la Tourette syndrome.

Brain Commun

March 2024

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden 01069, Germany.

Gilles de la Tourette syndrome is a neurodevelopmental disorder characterized by motor and vocal tics. It is associated with enhanced processing of stimulus-response associations, including a higher propensity to learn probabilistic stimulus-response contingencies (i.e.

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A systematic review of rehabilitation programs for cognitive impairment related to breast cancer: Different programs at different times?

Ann Phys Rehabil Med

June 2024

Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, TRAJECTOIRES, 95 Boulevard Pinel, 69500 Bron, France; Hybrid team, Inria, Campus de Beaulieu, 263 Av. Général Leclerc, 35042 Rennes, France.

Article Synopsis
  • Cancer Related Cognitive Impairment (CRCI) affects many breast cancer survivors, with 20-30% showing cognitive issues, and there’s no standard treatment despite various interventions available.
  • A systematic review of studies from 2019-2023 included 35 randomized controlled trials with 2821 participants and categorized interventions into cognitive rehabilitation, physical activity, complementary therapy, and pharmacological treatments.
  • Findings indicated that while pharmacological treatments had no effect, early physical activity interventions improved Quality of Life and cognitive processing speed, while later interventions enhanced memory, attention, and overall mental well-being, highlighting the need for holistic, multi-modal rehabilitation approaches.
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Hoarding disorder is an under-recognized condition characterized by the excessive acquisition of possessions and difficulty in disposing of them, which can have dramatic consequences. As hoarding disorder is difficult to treat and associated with high levels of disability in all areas of functioning, there appears to be a critical need to develop novel, tailored therapeutic strategies. Non-invasive brain stimulation techniques hold promise as potential therapeutic interventions for various psychiatric conditions and as a tool to modulate impulsivity when applied over the dorsolateral prefrontal cortex (DLPFC).

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Schizophrenia is characterized by the misattribution of emotional significance to neutral faces, accompanied by overactivations of the limbic system. To understand the disorder's genetic and environmental contributors, investigating healthy first-degree relatives is crucial. However, inconsistent findings exist regarding their ability to recognize neutral faces, with limited research exploring the cerebral correlates of neutral face processing in this population.

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Article Synopsis
  • Myocardial infarction (MI) causes heart muscle damage due to blocked blood flow, leading to the production of reactive oxygen species and a redox imbalance, with myoglobin playing a key role in this process.
  • The study introduces a new imaging method that uses advanced techniques to examine the oxidation-reduction states of myoglobin in heart tissue after MI, revealing how myoglobin's fluorescence can indicate the state of the myocardium.
  • Findings show that the spectral properties of myoglobin in infarcted heart tissue correlate with infarct size, suggesting myoglobin's redox state could be a valuable biomarker for assessing MI severity in its early stages.
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Objective: We investigated maternal and paternal sleep evolution from 3 to 36 months postpartum, their interrelations and predictors in the SEPAGES cohort.

Methods: Sleep information (night sleep duration [NSD], weekend daytime sleep duration [DSD] and subjective sleep loss [SSL]) was collected by self-administered questionnaires at 3, 18, 24 and 36 months postpartum in the SEPAGES French cohort that included 484 mothers and 410 fathers. Group-based multi-trajectory modelling was used to identify maternal, paternal and couple sleep multi-trajectory groups among 188 couples reporting sleep data for at least 2 time points.

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It has been suggested that cross-frequency coupling in cortico-hippocampal networks enables the maintenance of multiple visuo-spatial items in working memory. However, whether this mechanism acts as a global neural code for memory retention across sensory modalities remains to be demonstrated. Intracranial EEG data were recorded while drug-resistant patients with epilepsy performed a delayed matched-to-sample task with tone sequences.

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Chunking as a function of sequence length.

Anim Cogn

March 2024

Aix Marseille Univ, CNRS, LPC, Marseille, France.

Chunking mechanisms are central to several cognitive processes. During the acquisition of visuo-motor sequences, it is commonly reported that these sequences are segmented into chunks leading to more fluid, rapid, and accurate performances. The question of a chunk's storage capacity has been often investigated but little is known about the dynamics of chunk size evolution relative to sequence length.

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The rise in the global population of older adults underscores the significance to investigate age-related cognitive disorders and develop early treatment modalities. Previous research suggests that non-invasive transcranial Alternating Current Stimulation (tACS) can moderately improve cognitive decline in older adults. However, non-declarative cognition has received relatively less attention.

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Background/objective: Source monitoring refers to the ability to determine the source of memories and encompasses three subprocesses: internal source monitoring, reality monitoring, and external source monitoring. Neuroimaging studies provide valuable insights about neural correlates of source monitoring, but the causal relationship between brain and behavior is lacking. This study aimed to identify brain circuits involved in source monitoring by synthesizing the effects of brain stimulation on source monitoring as a function of the targeted brain regions or circuits.

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State-dependent alteration of respiration in a rat model of Parkinson's disease.

Exp Neurol

May 2024

Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, CMO, Centre Hospitalier Le Vinatier, Bâtiment 452, Neurocampus Michel Jouvet - 95 Bd Pinel, 69675 Bron Cedex, France. Electronic address:

Article Synopsis
  • Parkinson's disease (PD) is not only characterized by motor coordination issues but also by sensory and cognitive impairments, including altered respiration patterns, which are influenced by different behavioral states.
  • A study using a neurotoxin-induced rat model of PD found that these rats exhibited higher respiratory frequencies and amplitudes during quiet waking and exploration compared to control rats, with no notable differences during sleep.
  • The research highlights the need to consider how behavioral states affect respiration in PD, while also indicating that olfactory abilities, measured through sniffing responses, did not significantly differ between PD rats and controls.
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Introduction: The ability of repetitive transcranial magnetic stimulation (rTMS) to deliver a magnetic field (MF) in deep brain targets is debated and poorly documented.

Objective: To quantify the decay of MF in the human brain.

Methods: Magnetic field was generated by single pulses of TMS delivered at maximum intensity using a flat or angulated coil.

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Brain functional and structural changes lead to cognitive decline during aging, but a high level of cognitive stimulation during life can improve cognitive performances in the older adults, forming the cognitive reserve. Noradrenaline has been proposed as a molecular link between environmental stimulation and constitution of the cognitive reserve. Taking advantage of the ability of olfactory stimulation to activate noradrenergic neurons of the locus coeruleus, we used repeated olfactory enrichment sessions over the mouse lifespan to enable the cognitive reserve buildup.

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A data set of symptoms and needs of individuals affected by COVID-19.

Sci Data

January 2024

Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, NEUROPOP, F-69500, Bron, France.

Here we provide data from an online survey of 639 people diagnosed with COVID-19 and resident in France, who were diagnosed with COVID-19 between 30th Jan 2020 and 29th August 2022. In addition to demographic information the survey includes questions about participants' symptoms (by category), symptom onset and persistence, and the effects these symptoms had on their daily lives. Participants were able to include information related to their perceived medical, social and professional needs.

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The menstrual cycle is influenced by weekly and lunar rhythms.

Fertil Steril

April 2024

Centre de Recherche en Neurosciences de Lyon (CRNL), Neurocampus, Université de Lyon, Lyon, France. Electronic address:

Objective: To study whether the menstrual cycle has a circaseptan (7 days) rhythm and whether it is associated with the lunar cycle (also defined as the synodic month, it is the cycle of the phases of the Moon as seen from Earth, averaging 29.5 days in length).

Design: Cross-sectional study.

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Correctly assessing children's theory of mind (TOM) is essential to clinical practice. Yet, most tasks heavily rely on language, which is an obstacle for several populations. Langdon and Coltheart's (Cognition 71(1):43-71, 1999) Picture Sequencing Task (PST), developed for research purposes, avoids this limitation through a minimally-verbal procedure.

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Mechanistic account of the left auditory cortex for tone-matching in schizophrenia: A pilot transcranial random noise stimulation (tRNS) sham-controlled study.

Asian J Psychiatr

February 2024

Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, PSYR2, F-69500 Bron, France; Centre Hospitalier Le Vinatier, F-69500 Bron, France. Electronic address:

Objective: Deficits in the ability to match tones following brief delay and their contribution to higher-order cognitive alterations have been repeatedly documented in schizophrenia. The aim was to explore if left fronto-temporal high-frequency transcranial random noise stimulation (hf-tRNS), with electrodes placed over brain regions involved in tone-matching would significantly modulate performances in participants with schizophrenia.

Methods: In a randomized, double-blind sham-controlled study, 10 participants with schizophrenia were allocated to receive ten sessions of either active or sham hf-tRNS.

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Salivary α-amylase as a marker of sleep disorders: A theoretical review.

Sleep Med Rev

April 2024

Centre de Recherche en Neurosciences de Lyon (CRNL), INSERM, Lyon, France; Pediatric Sleep Unit and CRMR Narcolepsie-Hypersomnies Rares, Department of Pediatric Clinical Epileptology, Sleep Disorders and Functional Neurology, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France.

Sleep disorders are commonplace in our modern societies. Specialized hospital departments are generally overloaded, and sleep assessment is an expensive process in terms of equipment, human resources, and time. Biomarkers would usefully complement current measures in the screening and follow-up of sleep disorders and their daytime repercussions.

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Background: Following a traumatic event, 40-80% of the patients with acute stress disorder (ASD) will develop post-traumatic stress disorder (PTSD), 67% at 6 months. Alpha1-blockers are effective in treating some symptoms of PTSD but their usefulness in acute stress situations remains unclear. We hypothesized that reducing noradrenergic hyperactivity with an alpha1-blocker during the acute phase after a traumatic event could prevent the transition to PTSD in patients with ASD.

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