6 results match your criteria: "Centre de Ressources Biologiques Biobank Lariboisière (BB-0033-00064)[Affiliation]"
Validation of metaxin-2 deficient C. elegans as a model for MandibuloAcral Dysplasia associated to mtx-2 (MADaM) syndrome.
Commun Biol
October 2024
Université Paris Cité, INSERM UMR 1141 "NeuroDiderot", FHU Iio2-D2, Paris, France.
Article Synopsis
- MandibuloAcral Dysplasia associated to MTX2 gene (MADaM) is an accelerated aging disease characterized by skin issues, growth delays, and heart-related problems.
- Research using mtx-2-deficient C. elegans (a type of worm) shows they exhibit similar aging characteristics to humans with MADaM, including rougher skin texture and poor mitochondrial function.
- The findings from various analyses support these worms as a promising model to explore MADaM's molecular mechanisms and help develop potential treatments.
Whole blood transcriptome signature predicts severe forms of COVID-19: Results from the COVIDeF cohort study.
Funct Integr Genomics
May 2024
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, F-75014, Paris, France.
COVID-19 is associated with heterogeneous outcome. Early identification of a severe progression of the disease is essential to properly manage the patients and improve their outcome. Biomarkers reflecting an increased inflammatory response, as well as individual features including advanced age, male gender, and pre-existing comorbidities, are risk factors of severe COVID-19.
View Article and Find Full Text PDFExpression, Prognostic Value and Correlation with HPV Status of Hypoxia-Induced Markers in Sinonasal Squamous Cell Carcinoma.
J Pers Med
April 2023
Otorhinolaryngology and Skull Base Center, AP-HP, Hôpital Lariboisière, 75010 Paris, France.
Article Synopsis
- In head and neck squamous cell carcinoma, tumor hypoxia is linked to resistance to treatment and poor outcomes, while HPV-positive patients tend to have better responses and survival rates.
- A study focused on patients with squamous cell carcinoma of the nasal cavity and sinuses assessed the expression of hypoxia-related proteins and their correlation with HPV status and overall survival.
- Results showed high expression of CA-IX as a potential negative prognostic indicator, while no significant correlation was found between HPV status and the expression of hypoxia markers.
Nanopore Discrimination of Coagulation Biomarker Derivatives and Characterization of a Post-Translational Modification.
ACS Cent Sci
February 2023
LAMBE, CNRS, CY Cergy Paris Université, 95033 Cergy, France.
One of the most important health challenges is the early and ongoing detection of disease for prevention, as well as personalized treatment management. Development of new sensitive analytical point-of-care tests are, therefore, necessary for direct biomarker detection from biofluids as critical tools to address the healthcare needs of an aging global population. Coagulation disorders associated with stroke, heart attack, or cancer are defined by an increased level of the fibrinopeptide A (FPA) biomarker, among others.
View Article and Find Full Text PDFCirculating Tumor Cells in Cancer Diagnostics and Prognostics by Single-Molecule and Single-Cell Characterization.
ACS Sens
February 2023
Centre de Ressources Biologiques Biobank Lariboisière (BB-0033-00064), DMU BioGem, AP-HP, 75010 Paris, France.
Circulating tumor cells (CTCs) represent an interesting source of biomarkers for diagnosis, prognosis, and the prediction of cancer recurrence, yet while they are extensively studied in oncobiology research, their diagnostic utility has not yet been demonstrated and validated. Their scarcity in human biological fluids impedes the identification of dangerous CTC subpopulations that may promote metastatic dissemination. In this Perspective, we discuss promising techniques that could be used for the identification of these metastatic cells.
View Article and Find Full Text PDFMonocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID-19 in type 2 diabetes.
EMBO Mol Med
October 2020
Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Université, Université de Paris, Paris, France.
Early in the COVID-19 pandemic, type 2 diabetes (T2D) was marked as a risk factor for severe disease and mortality. Inflammation is central to the aetiology of both conditions where variations in immune responses can mitigate or aggravate disease course. Identifying at-risk groups based on immunoinflammatory signatures is valuable in directing personalised care and developing potential targets for precision therapy.
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