4 results match your criteria: "Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine (CHU Sainte-Justine)[Affiliation]"
Specific alterations in NKG2D T lymphocytes in relapsing-remitting and progressive multiple sclerosis patients.
Mult Scler Relat Disord
March 2023
Department of Neurosciences, Université de Montréal and Centre de Recherche du CHUM (CRCHUM) 900 St-Denis Street Montreal, QC, Canada, H2X0A9. Electronic address:
Article Synopsis
- - The study investigates changes in T lymphocytes related to multiple sclerosis (MS) and focuses on the NKG2D pathway, which is crucial for CD4 and CD8 T cell activation, revealing that its activity varies across different forms of MS (RRMS, SPMS, and PPMS).
- - Using flow cytometry and microscopy, researchers found that NKG2D T lymphocytes are less abundant in RRMS patients compared to healthy controls, and their proportion decreases with age in PPMS patients due to reduced γδ and αβ CD4CD8 populations.
- - Blocking NKG2D in co-cultured CD8 T lymphocytes and astrocytes resulted in increased mobility and a shift from long-lasting
Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8 T-Cell Behaviors.
Neurol Neuroimmunol Neuroinflamm
January 2022
From the Department of Neurosciences (A.C.M., Y.C.S., F.L., N.F-k., A.L., S.E.J.Z., M.G., P.D., C.L., A.P., N.A.), Université de Montréal and Centre de Recherche du CHUM (CRCHUM) Montreal; MS-CHUM Clinic (B.L., M.G., P.D., C.L., A.P.); CLSC des Faubourgs (J.V.G.), CIUSSS du Centre-Sud-de-l'Ile-de-Montréal; and Department of Microbiology, Infectious Diseases, and Immunology and Department of Pediatrics (E.H.), Université de Montréal, Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine (CHU Sainte-Justine), Montreal, Quebec, Canada.
Background And Objectives: We posit the involvement of the natural killer group 2D (NKG2D) pathway in multiple sclerosis (MS) pathology via the presence of specific NKG2D ligands (NKG2DLs). We aim to evaluate the expression of NKG2DLs in the CNS and CSF of patients with MS and to identify cellular stressors inducing the expression of UL16-binding protein 4 (ULBP4), the only detectable NKG2DL. Finally, we evaluate the impact of ULBP4 on functions such as cytokine production and motility by CD8 T lymphocytes, a subset largely expressing NKG2D, the cognate receptor.
View Article and Find Full Text PDFCapturing T Lymphocytes' Dynamic Interactions With Human Neural Cells Using Time-Lapse Microscopy.
Front Immunol
October 2021
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
To fully perform their functions, T lymphocytes migrate within organs' parenchyma and interact with local cells. Infiltration of T lymphocytes within the central nervous system (CNS) is associated with numerous neurodegenerative disorders. Nevertheless, how these immune cells communicate and respond to neural cells remains unresolved.
View Article and Find Full Text PDFHumanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis.
J Clin Invest
May 2018
Department of Microbiology, Infectious Diseases, and Immunology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Rasmussen's encephalitis (RE) is a chronic inflammatory brain disorder that causes frequent seizures and unilateral hemispheric atrophy with progressive neurological deficits. Hemispherectomy remains the only treatment that leads to seizure freedom for this refractory epileptic syndrome. The absence of an animal model of disease has been a major obstacle hampering the development of effective therapies.
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