3 results match your criteria: "Centre de Recherche du CHU St-Justine[Affiliation]"
Gut virome and microbiome dynamics before and after SARS-CoV-2 infection in women living with HIV and their infants.
Gut Microbes
August 2024
Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Microbiome perturbations can have long-term effects on health. The dynamics of the gut microbiome and virome in women living with HIV (WLHIV) and their newborn infants is poorly understood. Here, we performed metagenomic sequencing analyses on longitudinal stool samples including 23 mothers (13 WLHIV, 10 HIV-negative) and 12 infants that experienced SARS-CoV-2 infection with mild disease, as well as 40 mothers (18 WLHIV, 22 HIV-negative) and 60 infants that remained SARS-CoV-2 seronegative throughout the study follow-up.
View Article and Find Full Text PDFHIV and SARS-CoV-2 infection in postpartum Kenyan women and their infants.
PLoS One
January 2023
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Centre de Recherche du CHU St-Justine, Montréal, Québec, Canada.
Background: HIV may increase SARS-CoV-2 infection risk and COVID-19 severity generally, but data are limited about its impact on postpartum women and their infants. As such, we characterized SARS-CoV-2 infection among mother-infant pairs in Nairobi, Kenya.
Methods: We conducted a nested study of 62 HIV-uninfected and 64 healthy women living with HIV, as well as their HIV-exposed uninfected (N = 61) and HIV-unexposed (N = 64) infants, participating in a prospective cohort.
Comparison of nucleocapsid and spike antibody ELISAs for determining SARS-CoV-2 seropositivity in Kenyan women and infants.
J Med Virol
January 2023
Department of Global Health, Hans Rosling Center, University of Washington, Seattle, Washington, USA.
Article Synopsis
- A variety of ELISAs have been created to detect SARS-CoV-2 antibodies since the pandemic began, highlighting the need to evaluate their reliability across different populations.
- This study compares the Platelia Total Ab Assay (Bio-Rad) with the Mount Sinai spike IgG ELISA using plasma samples from a mother-infant group in Nairobi, finding a high agreement (92.7%) and strong correlation (R = 0.973) between the two assays.
- The results suggest that both assays provide similar seroprevalence estimates for the Kenyan population and are effective regardless of HIV exposure status, supporting the Platelia assay as a viable option for seroprevalence research in Kenya.