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Centre de Recherche du CHU Sainte-Justi... Publications | LitMetric

233 results match your criteria: "Centre de Recherche du CHU Sainte-Justine[Affiliation]"

: University students experience ≈ 9 h of sitting/day, which may support interventions like active desks. University students ( = 24) Method: Randomized crossover trial aimed to compare effects of sitting (SED), low and moderate-intensity cycling desks (CD; CD) concurrent to an academic task (30-minute video + written exam). Selective visual attention (Tobii Glasses 2) was measured throughout the intervention, and workload (NASA-TLX) and anxiety (POMS-SF) were assessed before and after the video and post-exam.

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Anterior vertebral tethering (AVT) is a non-invasive spine surgery technique, treating severe spine deformations and preserving lower back mobility. However, patient positioning and surgical strategies greatly influences postoperative results. Predicting the upright geometry from pediatric spines is needed to optimize patient positioning in the operating room (OR) and improve surgical outcomes, but remains a complex task due to immature bone properties.

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Importance: Dual language learners (DLL) (ie, children learning 2 or more languages) present lower school readiness than non-DLL children, putting DLL children at risk of later school difficulties and adverse outcomes. However, it is unclear whether participation in early childhood education and care (ECEC) services may reduce this gap.

Objective: To assess whether ECEC exposure may reduce the school readiness gap between DLL and non-DLL children in a population-based sample.

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SCIseg: Automatic Segmentation of Intramedullary Lesions in Spinal Cord Injury on T2-weighted MRI Scans.

Radiol Artif Intell

January 2025

From the NeuroPoly Laboratory, Institute of Biomedical Engineering, Polytechnique Montréal, 2500 Chemin de Polytechnique, Montréal, Québec, Canada H3T 1J4 (E.N.K., J.V., J.C.A.); Mila-Quebec AI Institute, Montréal, Québec, Canada (E.N.K., J.V., J.C.A.); Department of Neurosurgery and Department of Neurology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czechia (J.V.); Department of Physical Medicine and Rehabilitation Physical Therapy Program, University of Colorado School of Medicine, Aurora, Colo (A.C.S.); Spinal Cord Injury Center, Balgrist University Hospital, University of Zürich, Zürich, Switzerland (D.P., S.S.S., L.F., P.F.); Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, Calif (D.P., K.A.W.); Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (P.F.); and Functional Neuroimaging Unit, CRIUGM and Centre de Recherche du CHU Sainte-Justine, Université de Montréal, Montréal, Québec, Canada (J.C.A.).

Article Synopsis
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Endoplasmic Reticulum Stress Delays Choroid Development in the HCAR1 Knockout Mouse.

Am J Pathol

December 2024

Program in Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, Quebec, Canada; Department of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada; School of Optometry, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

The subretina, composed of the choroid and the retinal pigment epithelium (RPE), plays a critical role in proper vision. In addition to phagocytosis of photoreceptor debris, the RPE shuttles oxygen and nutrients to the neuroretina. For their own energy production, RPE cells mainly rely on lactate, a major by-product of glycolysis.

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Objectives: While studies have demonstrated increased morbidity and mortality risk in infancy among children who are HIV-exposed and uninfected (CHEU), longitudinal data are limited. The objective of this study was to assess long-term risk of hospitalization among CHEU compared to children who are HIV-unexposed and uninfected (CHUU), and determine risk factors for hospitalization among CHEU.

Design: A longitudinal cohort study (1988-2015) linking the Centre maternel et infantile sur le SIDA cohort (Montreal, Quebec) to administrative data from the Régie de l'assurance maladie du Québec (RAMQ), a universal health insurance provider in the province of Quebec.

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Article Synopsis
  • The TRIO gene has been linked to intellectual deficiency, autism spectrum disorder, and developmental epileptic encephalopathies due to recessive and de novo mutations.
  • Research indicates that TRIO is essential for the migration of GABAergic interneurons, specifically regulating their movement during brain development through its guanine nucleotide exchange factor (GEF) domains.
  • In studies involving Trio mutant mice, findings revealed reduced numbers of migrating interneurons, leading to increased seizures and behavioral issues, highlighting TRIO's crucial role in maintaining cortical inhibition and proper neuronal migration dynamics.
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Abstracts of the LXI Symposium of ISCEV, September 2024 Estérel, Québec.

Doc Ophthalmol

September 2024

Department of Ophthalmology, Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada.

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On the impact of B0 shimming algorithms on single-voxel MR spectroscopy.

Magn Reson Med

January 2025

NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, Quebec, Canada.

Purpose: To assess the impact of different B0 shimming algorithms on MRS.

Methods: B0 field maps and single-voxel MR spectroscopy were acquired in the prefrontal cortex of five volunteers at 3 T using five different B0 shimming approaches. B0 shimming was achieved using Siemens' proprietary shim algorithm, in addition to the Pseudo-Inverse (PI), Quadratic Programming (QuadProg), Least Squares (LSq), and Gradient optimization (Grad) algorithms.

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Unique Functional Neuroimaging Signatures of Genetic Versus Clinical High Risk for Psychosis.

Biol Psychiatry

January 2025

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California; Department of Psychology, University of California, Los Angeles, Los Angeles, California. Electronic address:

Background: 22q11.2 deletion syndrome (22qDel) is a copy number variant that is associated with psychosis and other neurodevelopmental disorders. Adolescents who are at clinical high risk for psychosis (CHR) are identified based on the presence of subthreshold psychosis symptoms.

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Purpose: To address emerging nutritional epidemiological research questions, data from contemporary cohorts are needed. CARTaGENE is the largest ongoing prospective cohort study of men and women in Québec, Canada. Dietary information was collected making it a rich resource for the exploration of diet in the aetiology of many health outcomes.

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Purpose: Advancing the development of 7 T MRI for spinal cord imaging is crucial for the enhanced diagnosis and monitoring of various neurodegenerative diseases and traumas. However, a significant challenge at this field strength is the transmit field inhomogeneity. Such inhomogeneity is particularly problematic for imaging the small, deep anatomical structures of the cervical spinal cord, as it can cause uneven signal intensity and elevate the local specific absorption ratio, compromising image quality.

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Objective: To investigate the association between African ancestry and neutrophil counts among children living with HIV (CLWH). We also examined whether medications, clinical conditions, hospitalization, or HIV virologic control were associated with low neutrophil counts or African ancestry.

Design: We conducted a secondary analysis of the Early Pediatric Initiation Canada Child Cure Cohort (EPIC4) Study, a multicenter prospective cohort study of CLWH across 8 Canadian pediatric HIV care centers.

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Introduction: Given the potential consequences associated with urinary tract infections (UTIs), it has become standard practice to use continuous antibiotic prophylaxis (CAP) in children, even if controversial. We reviewed the effectiveness of CAP on recurrent UTI in a pediatric population to determine if equipoise remains and allows for a placebo control group to study the effectiveness of the vaccine MV140.

Methods: We completed a rapid review.

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A unified stochastic SIR model driven by Lévy noise with time-dependency.

Adv Contin Discret Model

July 2024

Department of Mathematics and Statistics, Concordia University, Montreal, Canada.

We propose a unified stochastic SIR model driven by Lévy noise. The model is structural enough to allow for time-dependency, nonlinearity, discontinuity, demography, and environmental disturbances. We present concise results on the existence and uniqueness of positive global solutions and investigate the extinction and persistence of the novel model.

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Purpose: Exercise seems to influence taste, but the effect of exercise on specific tastes is still to be elucidated among youths.

Methods: Athlete boys aged 14-16 years were recruited. Participants (n = 19) ages ranged 14.

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Background: Optimizing a child's emergency department (ED) experience positively impacts their memories and future healthcare interactions. Our objectives were to describe children's perspectives of their needs and experiences during their ED visit and relate this to their understanding of their condition.

Methods: 514 children, aged 7-17 years, and their caregivers presenting to 10 Canadian pediatric EDs completed a descriptive cross-sectional survey from 2018-2020.

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Brain gray matter volume of reward-related structures in Inuit adolescents pre- and postnatally exposed to lead, mercury and polychlorinated biphenyls.

Neurotoxicology

July 2024

Département de Psychologie, Université du Québec à Montréal, 100 Sherbrooke Ouest, Montréal, Québec H2X 3P2,  Canada; Centre de Recherche du CHU Sainte-Justine, 3175, Chemin de la Côte-Sainte-Catherine, Montréal, Québec H3T 1C5, Canada. Electronic address:

This study aimed to assess associations between prenatal and postnatal exposure to lead (Pb), mercury (Hg) and polychlorinated biphenyls (PCBs) and gray matter volume of key regions of the brain reward circuit, namely the caudate nucleus, putamen, nucleus accumbens (nAcc), the amygdala, the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC). Structural magnetic resonance imaging (MRI) was conducted in 77 Inuit adolescents (mean age = 18.39) from Nunavik, Canada, who also completed the Brief Sensation Seeking Scale (BSSS-4) and Sensation Seeking - 2 (SS-2), two self-report questionnaires evaluating the tendency toward sensation seeking, which is a proxy of reward-related behaviors.

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While children have experienced less severe coronavirus disease (COVID-19) after SARS-CoV-2 infection than adults, the cause of this remains unclear. The objective of this study was to describe the humoral immune response to COVID-19 in child vs. adult household contacts, and to identify predictors of the response over time.

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The risk of aberrant growth of induced pluripotent stem cell (iPSC)-derived cells in response to DNA damage is a potential concern as the tumor suppressor genes TP53 and CDKN2A are transiently inactivated during reprogramming. Herein, we evaluate the integrity of cellular senescence pathways and DNA double-strand break (DSB) repair in Sendai virus reprogrammed iPSC-derived human fibroblasts (i-HF) compared to their parental skin fibroblasts (HF). Using transcriptomics analysis and a variety of functional assays, we show that the capacity of i-HF to enter senescence and repair DSB is not compromised after damage induced by ionizing radiation (IR) or the overexpression of H-RAS.

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Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study.

bioRxiv

May 2024

Division of Clinical Behavioral Neuroscience, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.

Article Synopsis
  • Clinical research typically requires careful study designs that account for variables like sex and age, but often overlooks body size factors like height and weight in neuroimaging studies.
  • This study analyzed data from 267 healthy adults to explore how body height and weight relate to various brain and spinal cord MRI metrics, finding significant correlations, especially with brain gray matter volume and cervical spinal cord area.
  • The results suggest that body size is an important biological variable that should be included in clinical neuroimaging study designs to enhance accuracy in understanding brain and spinal cord structures.
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Purpose: To address the limitations of spinal cord imaging at ultra-high field (UHF) due to time-consuming parallel transmit (pTx) adjustments. This study introduces calibration-free offline computed universal shim modes that can be applied seamlessly for different pTx RF coils and spinal cord target regions, substantially enhancing spinal cord imaging efficiency at UHF.

Methods: A library of channel-wise relative maps for the cervical spinal cord (six datasets) and thoracic and lumbar spinal cord (nine datasets) was constructed to optimize transmit homogeneity and efficiency for these regions.

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Purpose: T mapping is a widely used quantitative MRI technique, but its tissue-specific values remain inconsistent across protocols, sites, and vendors. The ISMRM Reproducible Research and Quantitative MR study groups jointly launched a challenge to assess the reproducibility of a well-established inversion-recovery T mapping technique, using acquisition details from a seminal T mapping paper on a standardized phantom and in human brains.

Methods: The challenge used the acquisition protocol from Barral et al.

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