1,691 results match your criteria: "Centre de Recherche Saint-Antoine[Affiliation]"

[A 2024 inventory in oncology news].

Bull Cancer

December 2024

UE7453 CHELTER, Inserm CIC-501, site Estaing, service de thérapie cellulaire et d'hématologie clinique adulte, service d'oncologie médicale, CHU de Clermont-Ferrand, Clermont-Ferrand, France.

The editorial board of the Bulletin du Cancer has compiled a summary of the news from 2024 in oncology, based on the main results presented at international congresses or published over the past year. After a year marked by the success of the Olympic Games, the selection of data is presented and discussed in podiums of three main results by topic. Emphasis is placed on studies that have an immediate impact on practice and on data that raise important questions for the year 2025.

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Improving the generalizability of white blood cell classification with few-shot domain adaptation.

J Pathol Inform

December 2024

Sorbonne Université, Inserm, Universite Sorbonne Paris-Nord, Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé, LIMICS, 15 Rue de l'École de Médecine, 75006 Paris, France.

The morphological classification of nucleated blood cells is fundamental for the diagnosis of hematological diseases. Many Deep Learning algorithms have been implemented to automatize this classification task, but most of the time they fail to classify images coming from different sources. This is known as "domain shift".

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Background & Aims: Liver biopsy contribution in patients with unexplained elevation of transaminases is not clearly established. The aim was to study liver biopsy contribution in patients with unexplained elevated transaminases strictly defined according to the current guidelines, reflecting the present clinical practice.

Methods: In a retrospective study, we identified all the liver biopsies performed in patients with elevated transaminases for at least six months.

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The intestinal microbiota is increasingly recognized as a crucial player in the development and maintenance of various chronic conditions, including obesity and associated metabolic diseases. While most research focuses on the fecal microbiota due to its easier accessibility, the small intestine, as a major site for nutrient sensing and absorption, warrants further investigation to determine its microbiota composition and functions. Here, we conducted a clinical research project in 30 age- and sex-matched participants with ( = 15) and without ( = 15) obesity.

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Introduction: Lipodystrophy syndromes are rare diseases characterized by a generalized or partial lipoatrophic morphotype and metabolic complications. Data on health-related quality of life and impact of genetic lipodystrophy on social or psychological well-being are lacking.

Patients And Methods: Patients with genetic lipodystrophy were recruited throughout the French national reference network for rare diseases of insulin secretion and insulin sensitivity.

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Pediatric acute myeloid leukemia frequently harbor fusion oncogenes associated with poor prognosis, including KMT2A, NUP98 and GLIS2 rearrangements. While murine models have demonstrated their leukemogenic activities, the steps from a normal human cell to leukemic blasts remain unclear. Here, we precisely reproduced the inversion of chromosome 16 resulting in ETO2::GLIS2 fusion in human induced pluripotent stem cells (iPSC).

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Systemic lupus erythematosus (SLE) is an autoimmune disease whose pathophysiology remains incompletely understood, involving genetic and epigenetic factors. However, an increasing small subset of patients present with monogenic lupus, providing insight into the pathogenesis of the disease. This systematic review focuses on SLE associated with A20 haploinsufficiency (HA20), a monogenic disorder associated with tumor necrosis factor alpha-induced protein 3 gene (TNFAIP3) variants.

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Minimal Residual Disease in Multiple Myeloma.

Presse Med

December 2024

Sorbonne Université, Centre de Recherche Saint-Antoine INSERM UMRs938, Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, AP-HP, Paris, France. Electronic address:

Minimal Residual Disease (MRD) in multiple myeloma has emerged as a significant prognostic factor, guiding treatment strategies and enhancing patient outcomes. Despite advancements in therapies such as proteasome inhibitors, immunomodulatory drugs, monoclonal antibodies, CAR-T cell therapy, and bispecific antibodies, complete eradication of malignant plasma cells remains challenging. MRD refers to a small number of residual cancer cells that persist after treatment and require sensitive methods like next-generation flow cytometry (NGF) and next-generation sequencing (NGS) for detection.

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Neuroinflammation in Alzheimer disease.

Nat Rev Immunol

December 2024

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette/Belvaux, Luxembourg.

Article Synopsis
  • Research highlights the significant role of immune processes in the development of Alzheimer's disease, which is the leading cause of dementia.
  • Various studies indicate that both innate and adaptive immune responses contribute to the disease's pathology and are influenced by genetics and lifestyle factors.
  • New therapeutic approaches targeting neuroinflammation are being explored in clinical settings, offering potential treatment options for Alzheimer's patients.
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Reproductive functions and fertility preservation in transgender men: A French case series.

J Gynecol Obstet Hum Reprod

December 2024

Service de Biologie de la Reproduction CECOS, Hôpital Tenon (AP-HP), Sorbonne-Université 75020 PARIS, France; Sorbonne Université, Centre de recherche Saint-Antoine, Inserm US938 75012 PARIS, France. Electronic address:

Background: Transgender men face reproductive challenges due to the potential impact on fertility of gender-affirming hormone therapy (GAHT) and surgical interventions. Testosterone therapy during "female to male" transition leads to anovulation and amenorrhea. Although these effects are typically reversible upon stopping treatment, the long-term effects of androgens on future fertility and health of potential children remain poorly known.

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International consensus statement on microbiome testing in clinical practice.

Lancet Gastroenterol Hepatol

December 2024

Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Medical and Surgical Sciences, UOC Gastroenterologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Electronic address:

There is growing interest in the potential exploitation of the gut microbiome as a diagnostic tool in medicine, but evidence supporting its clinical usefulness is scarce. An increasing number of commercial providers offer direct-to-consumer microbiome diagnostic tests without any consensus on their regulation or any proven value in clinical practice, which could result in considerable waste of individual and health-care resources and potential drawbacks in the clinical management of patients. We convened an international multidisciplinary expert panel to standardise best practices of microbiome testing for clinical implementation, including recommendations on general principles and minimum requirements for their provision, indications, pre-testing protocols, method of analyses, reporting of results, and potential clinical value.

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Long term noninvasive respiratory support in children with OSA-I and OSA-II: Data of a nation-wide study.

Sleep Med

November 2024

Pediatric Noninvasive Ventilation and Sleep Unit, AP-HP, Hôpital Necker-Enfants Malades, F-75015, Paris, France; Université de Paris Cité, EA 7330 VIFASOM, F-75004, Paris, France. Electronic address:

Purpose: The aim of the study was to analyze the characteristics of otherwise healthy children with obstructive sleep apnea (OSA; OSA-I) and children with OSA and non-syndromic obesity (OSA-II) treated with long term continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) in 2019 in France.

Methods: Data were collected from a national survey on paediatric home noninvasive ventilatory support. CPAP/NIV initiation criteria and duration, age at CPAP/NIV initiation, equipment used and CPAP/NIV settings, and objective compliance were analyzed.

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Intricate ribosome composition and translational reprogramming in epithelial-mesenchymal transition.

Proc Natl Acad Sci U S A

December 2024

"Ribosome, Translation and Cancer" Team, LabEx DEVweCAN, Institut Convergence Plascan, LYriCAN+, Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Centre Léon Bérard, Université de Lyon, Université Claude Bernard Lyon 1, Lyon 69008, France.

Epithelial-mesenchymal transition (EMT) involves profound changes in cell morphology, driven by transcriptional and epigenetic reprogramming. However, evidence suggests that translation and ribosome composition also play key roles in establishing pathophysiological phenotypes. Using genome-wide analyses, we reported significant rearrangement of the translational landscape and machinery during EMT.

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Article Synopsis
  • Cold piezoelectric plasma (CPP) is a new cancer treatment method that can lead to cancer cell death and the development of portable treatment devices, specifically targeting cholangiocarcinoma (CCA).
  • In vitro experiments use two types of CPP devices, corona discharge (Pz-CD) and dielectric barrier discharge (Pz-DBD), with Pz-CD delivering more power but both generating significant reactive species.
  • CPP shows immediate effects like remodeling of the actin cytoskeleton and long-term effects through activation of the DNA damage response pathway, suggesting its potential as an effective antitumor therapy.
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Surfactant protein B deficiency: the RespiRare cohort.

Thorax

December 2024

Assistance Publique - Hôpitaux de Paris, Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Armand Trousseau Hospital, Sorbonne University, Paris, France

Childhood interstitial lung diseases (chILD) are rare and usually severe disorders. Among them, very rare cases of surfactant protein (SP)-B deficiencies have been reported so far and are usually associated with fatal forms of chILD. The RespiRare network allows the collection of precise phenotypic and genotypic information.

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Trichophyton mentagrophytes ITS genotype VII infections among men who have sex with men in France: An ongoing phenomenon.

J Eur Acad Dermatol Venereol

November 2024

Department of Infectious Diseases, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Background: Trichophyton mentagrophytes ITS genotype VII (TMVII) has recently been identified in France as the causative agent of dermatophyte infections transmitted during sexual activity among men who have sex with men (MSM).

Objectives: Our objective was to provide new insights into the epidemiology, clinical presentation and treatment of TMVII infections based on cases diagnosed from October 2022 to September 2023 in three medical mycology laboratories in Paris. Additionally, we aimed to perform molecular characterization of TMVII strains collected in Paris, as well as in Switzerland.

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[First French data on sperm donation requests from female couples].

Gynecol Obstet Fertil Senol

November 2024

Service de biologie de la reproduction-CECOS, hôpital Tenon, AP-HP, Sorbonne université, 4, rue de la Chine, 75020 Paris, France; Inserm UMR 938, centre de recherche Saint-Antoine, CRSA, Sorbonne université, Paris, France. Electronic address:

Article Synopsis
  • * A study analyzed data from 117 women in same-sex couples and 75 women in heterosexual couples seeking MAR, comparing their profiles and ART outcomes from October 2021 to October 2022.
  • * Results showed no significant differences in age, ovarian reserve, or pregnancy outcomes between the two groups, indicating that women in same-sex couples have similar profiles and ART experiences to those in heterosexual couples following the law's implementation.
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High CD44 expression and enhanced E-selectin binding identified as biomarkers of chemoresistant leukemic cells in human T-ALL.

Leukemia

November 2024

Université Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, iRCM/SGCSR/Laboratoire des cellules Souches Hématopoïétiques et des Leucémies (LSHL), F-92260, Fontenay-aux-Roses, France.

Article Synopsis
  • * Research using single-cell RNA sequencing identified a specific group of chemotherapy-resistant leukemic cells (CLCs) that are quiescent and marked by high CD44 expression, allowing them to evade treatment.
  • * The study found that these CLCs exhibit unique gene activity and enhanced E-selectin binding during relapse, suggesting potential pathways for improving prognosis and developing new therapies.
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Introduction: Obstructive sleep-disordered breathing (OSDB) is the consequence of an anatomical and/or functional reduction in upper airway size during sleep. Young patients can also be affected. TROS type 1 (TROS1 ) is most often found in young, non-obese children with no associated comorbidities, presenting with an otorhinolaryngological (ENT) obstacle, generally an enlargement of lymphoid tissue (tonsils and/or adenoids).

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Non selective beta-blockers prevent PHT-related complications occurrence in HCC patients with esophageal varices treated by TACE.

Clin Res Hepatol Gastroenterol

November 2024

AP-HP Sorbonne Université, Hôpital Universitaire Pitié-Salpêtrière, Service d'Hépato-gastroentérologie, Paris, France; Sorbonne Université, UMRS-938, Centre de recherche Saint-Antoine (CRSA), INSERM, Paris, France.

Introduction: We aimed to investigate the parameters associated with portal hypertension (PHT)-related complications occurrence in hepatocellular carcinoma (HCC) patients treated by transarterial chemoembolization (TACE), with a focus on non-selective beta blockers (NSBBs) due to their impact on preventing liver decompensation.

Methods: We included all patients with HCC for whom endoscopy was available the day of first TACE (2013-2023). The occurrence of PHT-related complications was defined as the appearance of ascites, acute variceal bleeding or hepatic encephalopathy (HE) post-TACE treatment and prior to HCC progression.

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Lipids, from molecular mechanisms to diseases.

Biochimie

December 2024

Laboratoire de Physique de l'École normale supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, F-75005, Paris, France. Electronic address:

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Background: Heat stress (HS) commonly occurring in summer has gradually become a factor threatening the reproductive performance of male dairy goats by reducing their fecundity. Despite the melatonin is applied to relieve HS, it is still unclear whether melatonin protects against reproductive damage induced by HS in dairy goats and how it works. The purpose of the present study is to evaluate the role of melatonin in alleviating HS-induced spermatogenesis dysfunction in male dairy goats and further explore its mechanism.

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