372 results match your criteria: "Centre de Médecine Préventive Cardio-vasculaire[Affiliation]"

Right Atrial Cardiac Hemangioma: A Multidisciplinary Pathway From Symptoms to Surgery.

JACC Case Rep

December 2024

Groupement de Coopération Sanitaire-Groupement des Hôpitaux de l'Institut Catholique de Lille/Lille Catholic Hospitals, Heart Valve Center, Cardiology Department, DATACARD (Données Arythmie Technologie et imAgerie CARDio-vasculaire), ETHICS (Experience, technology & human interactions, care & society) EA 7446, Lille Catholic University, Lille, France.

We present a case of a 76-year-old man with de novo right heart failure. Echocardiography initially detected a mass near to the posterior area of the right atrium. Despite a comprehensive multimodality imaging assessment, the exact location of the mass remained unclear.

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Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score.

ESC Heart Fail

January 2025

Université de Strasbourg, Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Strasbourg, France.

Background And Objectives: Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis. This study aimed to evaluate the incremental prognostic utility of C-reactive protein (CRP) in conjunction with the InterTAK prognosis score for stratifying long-term mortality in Takotsubo syndrome.

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Purpose: Whether skin disinfection of the surgical site using chlorhexidine-alcohol is superior to povidone-iodine-alcohol in reducing reoperation and surgical site infection rates after major cardiac surgery remains unclear.

Methods: CLEAN 2 was a multicenter, open-label, randomized, two-arm, assessor-blind, superiority trial conducted in eight French hospitals. We randomly assigned adult patients undergoing major heart or aortic surgery via sternotomy, with or without saphenous vein or radial artery harvesting, to have all surgical sites disinfected with either 2% chlorhexidine-alcohol or 5% povidone-iodine-alcohol.

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Stroke and Death Following Carotid Endarterectomy or Carotid Artery Stenting: A Ten Year Nationwide Study in France.

Eur J Vasc Endovasc Surg

October 2024

Service de Biostatistiques et d'Information Médicale (DIM); CHU Dijon Bourgogne, Dijon, France; INSERM, Université de Bourgogne, CIC 1432, Module Épidémiologie Clinique, Dijon, France; Université Paris-Saclay, UVSQ, Inserm, CESP, Villejuif, France.

Objective: This retrospective, nationwide cohort study aimed to compare peri-procedural stroke or death within 30 days of the procedure (PPSD30) in patients who underwent carotid endarterectomy (CEA) or carotid stenting (CAS).

Methods: This retrospective cohort study used data from the French hospital database PMSI. All patients who underwent CEA or CAS between 2010 and 2019 in France were included.

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Background: Despite scarce data, invasive mechanical ventilation (MV) is widely suggested as first-line ventilatory support in cardiogenic shock (CS) patients. We assessed the real-life use of different ventilation strategies in CS and their influence on short and mid-term prognosis.

Methods: FRENSHOCK was a prospective registry including 772 CS patients from 49 centers in France.

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Article Synopsis
  • Neutrophil subsets with regulatory properties are often seen as harmful to immune responses against tumors and infections, but new findings suggest otherwise in cases of severe viral respiratory infections (VRI).
  • A significant population of neutrophils expressing programmed death-ligand 1 (PD-L1) was identified in humans and mice with VRI, exhibiting strong regulatory functions but diminished antimicrobial capabilities.
  • Depleting these PD-L1 neutrophils or blocking their function during VRI led to worse outcomes, indicating that they play a crucial role in managing inflammation and could be potential targets for future treatments.
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X-linked transient antenatal Bartter syndrome related to MAGED2 gene: Enriching the phenotypic description and pathophysiologic investigation.

Genet Med

July 2024

Université Paris Cité, Inserm, PARCC, Paris, France; Service de Médecine Génomique, Hôpital Européen Georges Pompidou, Fédération de Génétique et de Médecine Génomique Assistance Publique-Hôpitaux de Paris Centre Université Paris Cité, Paris, France; Centre de Recherche Cardio-vasculaire de Paris, UMR970, Paris, France. Electronic address:

Article Synopsis
  • Transient Bartter syndrome caused by MAGED2 variants is the newest type of antenatal Bartter syndrome and presents as the most severe form during the perinatal period; this study examines 14 new cases and the incomplete penetrance specifically in women.
  • The research involved 54 symptomatic patients, revealing a mix of outcomes: 27% resolved symptoms, 41% had ongoing complications, and 32% faced fatality, with common clinical anomalies including renal and cardiovascular issues.
  • The findings enhance the understanding of MAGED2’s phenotype and genetics, while also highlighting varying patient outcomes, which informs genetic counseling for affected families.
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Robotic-assisted thoracic surgery training in France: a nation-wide survey from young surgeons.

Interdiscip Cardiovasc Thorac Surg

July 2024

Association of Thoracic and Cardiovascular Surgeon in Training, Association des Jeunes Chirurgiens Thoracique et Cardio-Vasculaire, Paris, France.

Article Synopsis
  • A study was conducted to assess the training of thoracic surgeons-in-training in robotic-assisted thoracic surgery (RATS) across France, gathering responses from 101 participants.
  • Over half of the trainees had access to robotic systems, with a significant number considering robotic training essential, though only a small percentage had performed a complete procedure independently.
  • The findings suggest that training opportunities vary by institution, with higher exposure and performance among fellows at high-volume centers, highlighting the need for increased access and simulation training to improve skills in RATS.
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Potential of dapagliflozin to prevent vascular remodeling in the rat carotid artery following balloon injury.

Atherosclerosis

October 2024

UR 3074, Translational CardioVascular Medicine, Biomedicine Research Centre of Strasbourg, FMTS, Université de Strasbourg, Strasbourg, France; Université de Strasbourg, Pôle D'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Strasbourg, France; Hanoï Medical University, Hanoi, Viet Nam. Electronic address:

Article Synopsis
  • Sodium-glucose co-transporter 2 (SGLT2) inhibitors, like dapagliflozin, may reduce the risk of cardiovascular issues and possibly prevent blood vessel thickening after injury, which is not well understood.
  • In a study with male rats, dapagliflozin reduced neointima thickening by 32% compared to control and also impacted vascular responses without altering certain inflammatory and oxidative gene expressions.
  • The findings suggest that dapagliflozin works by affecting angiotensin and extracellular nucleotide signaling, indicating SGLT2 inhibitors could be a new approach for addressing vascular restenosis.
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Diagnosis of hemidiaphragm paralysis: refine ultrasound criteria.

Front Med (Lausanne)

May 2024

Laboratoire d'Exploration Fonctionnelle Respiratoire, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille, Marseille, France.

Article Synopsis
  • This study investigates diaphragm function using ultrasound in 103 patients with previously diagnosed diaphragm paralysis due to factors like trauma or surgery.
  • Results showed that the paralyzed hemidiaphragm had less than 20% thickening during deep inspiration, with many exhibiting paradoxical movement patterns during breathing.
  • The findings suggest that combining ultrasound measurements of diaphragm motion and thickening could enhance the accuracy of diagnosing hemidiaphragm paralysis.
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Article Synopsis
  • Children with cystic fibrosis (CF) often face acute respiratory failure due to severe pulmonary exacerbations, leading to pediatric intensive care unit (PICU) admissions, with a focus on understanding their short and medium-term outcomes.
  • A study reviewed data from patients under 18 years old admitted to a French PICU over two decades, utilizing statistical methods to identify factors influencing mortality and the need for lung transplants.
  • Results indicated high mortality rates (up to 41% within 3 years post-discharge) and identified key risk factors like gender, certain blood gas levels, and pre-admission health conditions, highlighting the critical need for early consideration of lung transplants as a survival option.
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Background: A delayed and recurrent complete atrioventricular block (CAVB) is a life-threatening complication of transcatheter aortic valve replacement (TAVR). Post-TAVR evaluation may be important in predicting delayed and recurrent CAVB requiring permanent pacemaker implantation (PPI). The impact of new-onset right bundle-branch block (RBBB) after TAVR on PPI remains unknown.

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Article Synopsis
  • A significant number of patients undergoing percutaneous coronary intervention (PCI) have few or no standard modifiable cardiovascular risk factors (SMuRFs), such as hypertension, diabetes, hypercholesterolemia, and smoking.
  • The study analyzed patients based on how many SMuRFs they had and found that as the number of SMuRFs increased, the risk of target lesion failure (TLF) also rose significantly.
  • Patients without SMuRFs had better outcomes, but there's a need for further research to improve treatment strategies for the majority who do have risk factors.
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Background: Liver transplantation (LT) is indicated in patients with severe acute or chronic liver failure for which no other therapy is available. With the increasing number of LTs in recent years, liver centers worldwide must manage their patients according to their clinical situation and the expected waiting time for transplantation. The LT clinic at the Centre hospitalier de l'Université de Montréal (CHUM) is developing a new health care model across the entire continuum of pre-, peri-, and posttransplant care that features patient monitoring by an interdisciplinary team, including an accompanying patient; a digital platform to host a clinical plan; a learning program; and data collection from connected objects.

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Sex disparities in cardiogenic shock: Insights from the FRENSHOCK registry.

J Crit Care

August 2024

Intensive Cardiac Care Unit, Cardiology department, Rangueil University Hospital, 1 Avenue Jean Poulhes, Toulouse, France; Recherche Enseignement en Insuffisance cardiaque Avancée Assistance et Transplantation (REICATRA), Institut Saint Jacques, CHU de Toulouse, France. Electronic address:

Background: Cardiogenic shock (CS) is the most severe form of acute heart failure. Discrepancies have been reported between sexes regarding delays, pathways and invasive strategies in CS complicating acute myocardial infarction. However, effect of sex on the prognosis of unselected CS remains controversial.

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Reducing length of stay after transfemoral transcatheter aortic valve implantation: the FAST-TAVI II trial.

Eur Heart J

March 2024

Univ Rouen Normandie, Inserm U1096, CHU Rouen, Department of Cardiology, F-76000 Rouen, France.

Background And Aims: The length of stay (LOS) after transcatheter aortic valve implantation (TAVI) remains extremely variable whereas early discharge has been shown to be feasible and safe. The study objective was to evaluate the efficacy and safety of an intervention aimed at reducing LOS after transfemoral TAVI.

Methods: FAST-TAVI II is a prospective, multicentre, cluster, randomized, controlled study including patients with severe symptomatic aortic stenosis, who had transfemoral TAVI.

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Background: Transcatheter tricuspid valve replacement (TTVR) abolishes tricuspid regurgitation (TR) and has emerged as a definitive treatment for TR.

Objectives: The purpose of this multicenter, observational study was to determine the clinical characteristics and short-term outcomes of patients with TR screened for TTVR.

Methods: Patients underwent TTVR screening at 7 centers on a compassionate-use basis.

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Reply.

Arthritis Rheumatol

August 2024

Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, New York, USA.

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Background: The effects of pharmacological therapy on cardiogenic shock (CS) survivors have not been extensively studied. Thus, this study investigated the association between guideline-directed heart failure (HF) medical therapy (GDMT) and one-year survival rate in patients who are post-CS.

Methods And Results: FRENSHOCK (French Observatory on the Management of Cardiogenic Shock in 2016) registry was a prospective multicenter observational survey, conducted in metropolitan French intensive care units and intensive cardiac care units.

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Regional anaesthesia via parasternal catheters inserted preoperatively and postoperative delirium after cardiac surgery: A prospective unrandomised clinical trial.

Eur J Anaesthesiol

June 2024

From the Département d'Anesthésie-Réanimation et Médecine Périopératoire (NE, NG, FS, JCP, SA, CM, SM, JM, JL), Département de Chirurgie Cardio-Vasculaire, Centre Hospitalier Universitaire de Saint-Etienne (KA, AP, KR, SC), Laboratoire de Pharmacologie Toxicologie, CHU Saint-Etienne (EO), Université de Lyon, UJM-Saint-Etienne, Laboratoire Interuniversitaire de Biologie de la Motricité (NE, JM), INSERM, U1059, Dysfonction Vasculaire et Hémostase, Saint-Etienne, France (SM, EO, JL).

http://links.lww.com/EJA/A927.

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Beyond MEN1, When to Think About MEN4? Retrospective Study on 5600 Patients in the French Population and Literature Review.

J Clin Endocrinol Metab

June 2024

CHU Lille, Service de Biochimie et Biologie moléculaire « Hormonologie, Métabolisme-Nutrition, Oncologie, 59000 Lille, France.

Context: Germline CDKN1B variants predispose patients to multiple endocrine neoplasia type 4 (MEN4), a rare MEN1-like syndrome, with <100 reported cases since its discovery in 2006. Although CDKN1B mutations are frequently suggested to explain cases of genetically negative MEN1, the prevalence and phenotype of MEN4 patients is poorly known, and genetic counseling is unclear.

Objective: To evaluate the prevalence of MEN4 in MEN1-suspected patients and characterize the phenotype of MEN4 patients.

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Background And Aims: Mitral valve surgery and, more recently, mitral transcatheter edge-to-edge repair (TEER) are the two treatments of severe mitral regurgitation in eligible patients. Clinical comparison of both therapies remains limited by the number of patients analysed. The objective of this study was to analyse the outcomes of mitral TEER vs.

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Article Synopsis
  • Thrombosis is a serious problem in people with a condition called antiphospholipid syndrome (APS), and tests exist to help diagnose it.
  • Scientists created a type of computer program called an artificial neural network (NN) to help diagnose APS in patients taking certain blood-thinning medications.
  • They found that this new tool could accurately diagnose APS in patients without needing them to stop their medication, which is super helpful for those at risk of blood clots.
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Article Synopsis
  • - The beta-adrenergic signaling pathway is crucial in managing heart failure (HF), with beta-blockers (BBs) being the first-line treatment for patients with HF and reduced ejection fraction (HFrEF).
  • - In cases of severe acute heart failure (AHF), particularly those recovering from cardiogenic shock, starting BB therapy can be risky due to a lack of comprehensive data.
  • - An expert consensus has been developed to review existing studies on BB use in severe decompensated AHF and offers a practical algorithm for prescribing and monitoring BB therapy in critical conditions.
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