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Cardiovascular autonomic dysfunction and sleep abnormalities in children with Prader-Willi syndrome.
Clin Auton Res
December 2024
Unité du Sommeil, Centre de Compétences Narcolepsie Et Hypersomnie Rare, Hôpital Pierre-Paul Riquet, CHU de Toulouse, Toulouse, France.
Article Synopsis
- Prader-Willi syndrome (PWS) is a rare genetic condition linked to cognitive and behavioral issues, obesity, and sleep problems, which may also involve autonomic nervous system dysfunction.
- A study investigated heart rate variability and autonomic function during sleep and standing in children with PWS, comparing results with age-matched controls, revealing significant impairment in heart rate responses and high rates of sleep apnea among the PWS group.
- Findings suggest decreased vagal modulation and possible sympathetic dysfunction in PWS children, which could increase their cardiovascular risks.