9 results match your criteria: "Centre d'ophtalmologie de l'Assistance Publique - Hôpitaux de Paris[Affiliation]"
The Impact of HLA-A29 Homozygosity and of the Second HLA-A Allele on Susceptibility and Severity of Birdshot Chorioretinitis.
Invest Ophthalmol Vis Sci
November 2024
Université Paris Cité, Centre d'ophtalmologie de l'Assistance Publique, Hôpitaux de Paris, Paris, France.
Purpose: HLA-A29 is the main susceptibility factor for birdshot chorioretinitis (BSCR). Our study assessed the impact of the second HLA-A allele alongside HLA-A29 on BSCR severity and susceptibility, focusing on HLA-A29 homozygous patients and those with alleles from the HLA-Aw19 group.
Methods: We included 120 additional cases to our previous analysis of 286 patients with BSCR, all HLA-A29 positive.
Quality of Life in Patients with Birdshot Chorioretinitis Aged 80 and Older.
Ocul Immunol Inflamm
September 2024
Centre d'ophtalmologie de l'Assistance Publique - Hôpitaux de Paris, Université Paris Cité, Paris, France, France.
Purpose: Birdshot chorioretinitis (BSCR) is an ocular HLA-related disease with variable clinical progression. We examine the quality of life (QOL) of BSCR individuals aged ≥80 years, providing insights into the long-term disease impact.
Methods: We utilized data from the CO-BIRD cohort (ClinicalTrials.
Visual acuity and visual field as a function of disease duration in patients with birdshot chorioretinitis.
Br J Ophthalmol
October 2024
Université Paris Cité, Centre d'ophtalmologie de l'Assistance Publique - Hôpitaux de Paris, Ophtalmologie - Hôpital Cochin 27 rue du faubourg Saint-Jacques, Paris, France
Article Synopsis
- Birdshot chorioretinitis (BSCR) is a chronic eye disease that affects both central and peripheral vision, prompting a study on how patients' visual acuity and field change over time.* -
- The study involved 447 patients and revealed that as the disease progressed, the best corrected visual acuity (BCVA) notably decreased, particularly after 11-15 years, and other visual field measurements worsened over longer durations.* -
- Findings indicated significant variability in visual outcomes among patients, which tended to worsen with disease duration, underscoring the need for monitoring and understanding the long-term effects of BSCR.*
Birdshot Chorioretinitis in Patients Aged 80 and Older.
Ocul Immunol Inflamm
September 2024
Université Paris Cité, Centre d'ophtalmologie de l'Assistance Publique - Hôpitaux de Paris, Paris, France.
Purpose: To assess the manifestations of birdshot chorioretinitis (BSCR) in patients aged 80 and over.
Design: Among patients with BSCR followed in the CO-BIRD prospective cohort (ClinicalTrials.gov Identifier: NCT05153057), we analyzed the subgroup of patients aged 80 and over.
Real-Life Efficacy, Safety, and Use of Dexamethasone Intravitreal Implant in Posterior Segment Inflammation Due to Non-infectious Uveitis (LOUVRE 2 Study).
Ophthalmol Ther
October 2022
Allergan, an AbbVie company, Courbevoie, France.
Introduction: To evaluate real-life efficacy, safety, and treatment patterns with the dexamethasone intravitreal implant (DEX) in posterior segment inflammation due to non-infectious uveitis (treatment-naïve or not) in French clinics.
Methods: In this prospective, multicenter, observational, non-comparative, post-reimbursement study, consecutive patients with posterior segment inflammation due to non-infectious uveitis were enrolled and evaluated at baseline (day 0). Those who received DEX on day 0 were re-evaluated at months 2, 6, and 18.
Transscleral filtration revealing a chorioretinal coloboma.
Am J Ophthalmol Case Rep
March 2021
Université de Paris, Centre d'Ophtalmologie de l'Assistance Publique - Hôpitaux de Paris, Hôpital Cochin, 27 rue du faubourg Saint-Jacques, 75014, Paris, France.
Purpose: We report the case of a 19-year-old patient who presented with an ocular hypotony due to a transscleral filtration through an isolated congenital chorioretinal coloboma in his right eye.
Observations: The initial examination showed a decimal best corrected visual acuity (BCVA) decreased to 0.7 and a marked hypotony.
Optical Coherence Tomography Angiography Analysis of Retinal and Choroidal Vascular Networks during Acute, Relapsing, and Quiescent Stages of Macular Toxoplasma Retinochoroiditis.
Biomed Res Int
April 2021
Rothschild Ophthalmological Foundation, 25 Rue Manin, 75940 Paris Cedex 19, France.
Purpose: To highlight the advantages of optical coherence tomography angiography (OCTA) in delineating the morphological features of the retinal and choroidal vascular network during acute, relapsing, and quiescent stages of macular toxoplasma retinochoroiditis.
Methods: This prospective study included patients presenting with both active and quiescent ocular toxoplasmoses. OCTA was obtained to diagnose and follow the subsequent vascular network changes at diagnosis and six months after acute presentation.
[New treatments for uveitis].
Rev Prat
May 2018
Université Paris-Descartes, Centre d'ophtalmologie de l'Assistance publique-Hôpitaux de Paris, hôpital Cochin, Paris, France.
Adalimumab in Active and Inactive, Non-Infectious Uveitis: Global Results from the VISUAL I and VISUAL II Trials.
Ocul Immunol Inflamm
November 2019
c Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine , Hokkaido University, Sapporo , Japan.
Purpose: Report global adalimumab safety and efficacy outcomes in patients with non-infectious uveitis.
Methods: Adults with non-infectious intermediate, posterior, or panuveitis were randomized 1:1 to receive placebo or adalimumab in the VISUAL I (active uveitis) or VISUAL II (inactive uveitis) trials. Integrated global and Japan substudy results are reported.