2 results match your criteria: "Centre d'immunologie et de maladie infectieuse[Affiliation]"
Alteration of splicing factors' expression during liver disease progression: impact on hepatocellular carcinoma outcome.
Hepatol Int
July 2019
INSERM U1135, Centre d'immunologie et de maladie infectieuse, 91 boulevard de l'Hôpital, 75013, Paris, France.
Purpose: Trans-acting splicing factors (SF) shape the eukaryotic transcriptome by regulating alternative splicing (AS). This process is recurrently modulated in liver cancer suggesting its direct contribution to the course of liver disease. The aim of our study was to investigate the relationship between the regulation of SFs expression and liver damage.
View Article and Find Full Text PDFAlternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity.
J Hepatol
October 2017
INSERM U1135, Centre d'immunologie et de maladie infectieuse, Paris, France; Université Pierre et Marie Curie, Paris, France; Service de Virologie, Hôpital Tenon, Paris, France. Electronic address:
Background & Aims: Hepatitis B virus (HBV) RNA can undergo alternative splicing, but the relevance of this post-transcriptional regulation remains elusive. The mechanism of HBV alternative splicing regulation and its impact on liver pathogenesis were investigated.
Methods: HBV RNA-interacting proteins were identified by RNA pull-down, combined with mass spectrometry analysis.