1 results match your criteria: "Centre d'Investigation Clinique CIC-P 9501 jDepartment of Geriatric Medicine[Affiliation]"
Central pulse pressure is a determinant of heart and brain remodeling in the elderly: a quantitative MRI and PET pilot study.
J Hypertens
July 2015
aDepartment of Nuclear Medicine, Nancyclotep Imaging Platform, CHU-Nancy bINSERM U947 cLorraine University, Nancy dDepartment of Nuclear Medicine, AP-HM, Hospital 'La Timone' eCNRS UMR7289, Institut de Neurosciences de la Timone, INT, Marseilles fINSERM, U1116, Nancy gINSERM, Centre d'Investigation Clinique CIC-IT 1433 hDepartment of Radiology, CHU-Nancy iINSERM, Centre d'Investigation Clinique CIC-P 9501 jDepartment of Geriatric Medicine, CHU-Nancy, Nancy, France.
Objective: The sustained elevation of blood pressure (BP) and especially of central pulse pressure (cPP) leads to heart and brain damage. This pilot study was aimed to precise the relationships between peripheral and central BP levels, and the remodeling of heart and brain as objectively quantified by cardiac MRI and brain F-fluorodeoxyglucose (FDG)-PET imaging in the elderly.
Methods: Twenty-eight apparently healthy elderly individuals (66-85 years old, 14 women) were prospectively recruited and allocated into two half groups, one with and one without hypertension, and all were referred for the quantitative determinations of peripheral and central BP using applanation tonometry, indexed left ventricular mass (per m of body surface area) using cardiac MRI, and brain metabolism with a voxel-based analysis of FDG-PET images adjusted for age and sex.