476 results match your criteria: "Centre d'Immunologie et des Maladies Infectieuses CIMI[Affiliation]"

Identification of bronchoalveolar and blood immune-inflammatory biomarker signature associated with poor 28-day outcome in critically ill COVID-19 patients.

Sci Rep

June 2022

Département de biochimie, INSERM Centre de Recherche Saint-Antoine (CRSA), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Sorbonne Université, Paris, France.

The local immune-inflammatory response elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still poorly described, as well as the extent to which its characteristics may be associated with the outcome of critical Coronavirus disease 2019 (COVID-19). In this prospective monocenter study, all consecutive COVID-19 critically ill patients admitted from February to December 2020 and explored by fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) were included. Biological assays, including digital ELISA cytokine profiling and targeted eicosanoid metabolomic analysis, were performed on paired blood and BAL fluid (BALF).

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Anticancer Drug-Induced Capillary Leak Syndrome.

Kidney Int Rep

May 2022

Division of Kidney Diseases and Hypertension, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, New York, USA.

The term capillary leak syndrome (CLS) describes the manifestations associated with an increased capillary permeability to proteins leading to an escape of plasma from the blood circulatory system to surrounding tissues, muscle, organs, or body cavities. This results clinically in the typical triad of hypotension, edema, and elevated hematocrit. The more severe cases of CLS may present with cardiovascular collapse, shock, and death.

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HDHL-INTIMIC: A European Knowledge Platform on Food, Diet, Intestinal Microbiomics, and Human Health.

Nutrients

April 2022

TNO (Netherlands Organisation for Applied Scientific Research), Microbiology and Systems Biology, 3704 HE Zeist, The Netherlands.

Studies indicate that the intestinal microbiota influences general metabolic processes in humans, thereby modulating the risk of chronic diseases such as type 2 diabetes, allergy, cardiovascular disease, and colorectal cancer (CRC). Dietary factors are also directly related to chronic disease risk, and they affect the composition and function of the gut microbiota. Still, detailed knowledge on the relation between diet, the microbiota, and chronic disease risk is limited.

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Autophagy is an essential cellular pathway that ensures degradation of a wide range of substrates including damaged organelles or large protein aggregates. Understanding how this proteolytic pathway is regulated would increase our comprehension on its role in cellular physiology and contribute to identify biomarkers or potential drug targets to develop more specific treatments for disease in which autophagy is dysregulated. Here, we report the development of molecular traps based in the tandem disposition of LC3-interacting regions (LIR).

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In-ICU-acquired infections in flare-up systemic rheumatic disease patients receiving immunosuppressant.

Clin Rheumatol

September 2022

Service de Médecine Interne 2, Centre de Référence National Lupus Systémique, Syndrome des Anticorps Anti-phospholipides et Autres Maladies Auto-Immunes Systémiques Rares, Sorbonne Université, Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital La Pitié-Salpêtrière, Institut E3M, 47-83, boulevard de l'Hôpital, 75651, Paris Cedex, France.

Objectives: Systemic rheumatic diseases (SRDs) are a group of inflammatory disorders that can need intensive care unit (ICU) admission during a flare-up, requiring administration of immunosuppressants. We undertook this study to determine the frequency, outcome, and occurrence associated factors of infections in flare-up SRD patients receiving immunosuppressant.

Methods: Monocenter, a retrospective study including SRD patients admitted to ICU for a flare-up requiring immunosuppressant from 2004 to 2019.

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Memory CD4+ T-Cell Lymphocytic Angiopathy in Fatal Forms of COVID-19 Pulmonary Infection.

Front Immunol

May 2022

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpêtrière, Service de Médecine Intensive Réanimation, Institut de Cardiologie, Paris, France.

The immunopathological pulmonary mechanisms leading to Coronavirus Disease (COVID-19)-related death in adults remain poorly understood. Bronchoalveolar lavage (BAL) and peripheral blood sampling were performed in 74 steroid and non-steroid-treated intensive care unit (ICU) patients (23-75 years; 44 survivors). Peripheral effector SARS-CoV-2-specific T cells were detected in 34/58 cases, mainly directed against the S1 portion of the spike protein.

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A comparison of Sars-Cov-2 vaccine platforms: the CoviCompare project.

Nat Med

May 2022

Université Paris Cité, National Institute for Health and Medical Research (INSERM) CIC 1417 Cochin Pasteur, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, Paris, France.

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Meningitis/encephalitis (ME) syndromic diagnostic assays can be applied for the rapid one-step detection of the most common pathogens in cerebrospinal fluid (CSF). However, the comprehensive performance of multiplex assays is still under evaluation. In our multisite university hospital of eastern Paris, France, ME syndromic testing has been gradually implemented since 2017 for patients with neurological symptoms presenting to an adult or pediatric emergency unit.

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Prevalence and factors associated with long-term remission in cutaneous lupus: A longitudinal cohort study of 141 cases.

J Am Acad Dermatol

August 2022

Sorbonne Université, Faculté de médecine, AP-HP, Service de Dermatologie et Allergologie, Hôpital Tenon, Paris, France. Electronic address:

Article Synopsis
  • - The study investigated the prevalence and factors linked to long-term remission in cutaneous lupus erythematosus (CLE) through data from 141 biopsy-proven patients, focusing on their demographic information and treatment outcomes over time.
  • - Results showed that 66% of patients achieved remission, but only 19% maintained long-term remission (over 3 years), with some patients managing it without systemic treatment; factors such as active smoking and the presence of discoid lesions were associated with lower remission rates.
  • - Limitations included reliance on partial retrospective data and the specific patient population from a tertiary care center, leading to the conclusion that long-term remission in CLE is uncommon and influenced by lifestyle and condition characteristics.
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Background: Targeting immune checkpoints that inhibit antitumor immune responses has emerged as a powerful new approach to treat cancer. We recently showed that blocking the tumor necrosis factor receptor-type 2 (TNFR2) pathway induces the complete loss of the protective function of regulatory T cells (Tregs) in a model of graft-versus-host disease (GVHD) prevention that relies on Treg-based cell therapy. Here, we tested the possibility of amplifying the antitumor response by targeting TNFR2 in a model of tumor relapse following hematopoietic stem-cell transplantation, a clinical situation for which the need for efficient therapeutic options is still unmet.

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The capacity of pre-existing immunity to human common coronaviruses (HCoV) to cross-protect against COVID-19is yet unknown. In this work, we studied the sera of 175 COVID-19 patients, 76 healthy donors and 3 intravenous immunoglobulins (IVIG) batches. We found that most COVID-19 patients developed anti-SARS-CoV-2 IgG antibodies before IgM.

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Article Synopsis
  • The tumor immune microenvironment (TIME) is made up of various myeloid cells that show complex identities and behaviors, making it hard to understand their role in T-cell function and patient outcomes.
  • Researchers used single-cell RNA-sequencing to analyze mouse and human tumors, discovering that the diversity of monocyte-macrophage cells is influenced by both lineage and transcriptional changes during their development.
  • In mice, the transformation from monocytes to macrophages was linked to the presence of regulatory T cells (Tregs), while in human kidney cancer, variations in macrophage types and myeloid cell makeup correlated with the density of Tregs and the effectiveness of CD8+ T cells.
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Industrial production of therapeutic monoclonal antibodies is mostly performed in eukaryotic-based systems, allowing posttranslational modifications mandatory for their functional activity. The resulting elevated product cost limits therapy access to some patients. To address this limitation, we conceptualized a novel immunotherapeutic approach to redirect a preexisting polyclonal antibody response against Epstein-Barr virus (EBV) toward defined target cells.

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Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old.

EBioMedicine

February 2022

Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Université, INSERM U1135, 75013 Paris, France; Université de Bordeaux, CNRS UMR5164, INSERM ERL1303, ImmunoConcEpT, Bordeaux, France; International Research Center of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address:

Background: Advanced age is accompanied by a decline of immune functions, which may play a role in increased vulnerability to emerging pathogens and low efficacy of primary vaccinations in elderly people. The capacity to mount immune responses against new antigens is particularly affected in this population. However, its precise determinants are not fully understood.

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Lower Rate of Daily Smokers With Symptomatic COVID-19: A Monocentric Self-Report of Smoking Habit Study.

Front Med (Lausanne)

January 2022

Sorbonne Université, Inserm UMR-S 1135, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Groupe Hospitalier Universitaire APHP.Sorbonne-université, site Pitié-Salpêtrière, service de médecine interne 2, Paris, France.

Article Synopsis
  • A study conducted at a French University hospital examined the smoking habits of COVID-19 patients, both inpatients and outpatients, to determine any potential link between smoking and severity of symptoms.
  • Among the inpatient group (340 patients), only 4.1% were daily smokers, while the outpatient group (139 patients) had a slightly higher rate of 6.1%. These rates were significantly lower than those found in the general French population.
  • Furthermore, the research indicated that among the severe cases, including patients who died or were transferred to intensive care, the percentage of daily smokers was minimal, suggesting that smoking might not be a risk factor for severe COVID-19 outcomes.
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Evolution of anti-SARS-CoV-2 immune response in a cohort of French healthcare workers followed for 7 months.

Infect Dis Now

March 2022

Institut Micalis UMR 1319, université Paris-Saclay, INRAe, AgroParisTech, Châtenay, Malabry, France; Service de microbiologie clinique, Groupe hospitalier Paris Saint-Joseph, Paris, France.

Objectives: We aimed to understand the immune response among healthcare workers (HCWs) following SARS-CoV-2 infection, and to determine the infection prevalence during the first wave of the pandemic among workers in our hospital.

Methods: Determination of the serological status against SARS-CoV-2 (nucleocapsid) was offered to all HCWs. All HCWs with positive SARS-CoV-2 serology were proposed to be included in a longitudinal medical and serological follow-up (anti-spike) for 7months.

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[medecine/sciences 2022, a passion for research…].

Med Sci (Paris)

January 2022

Rédacteur en chef de médecine/sciences, directeur de recherche émérite à l'Inserm, équipe « Microenvironnement immunitaire et immunothérapie », Centre d'immunologie et des maladies infectieuses (CIMI-Paris), Inserm UMRS 1135, Sorbonne université, 91 boulevard de l'Hôpital, 75013 Paris, France.

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Investigations upon the Improvement of Dermatophyte Identification Using an Online Mass Spectrometry Application.

J Fungi (Basel)

January 2022

AP-HP (Assistance Publique-Hôpitaux de Paris), Service de Parasitologie Mycologie, Hôpital La Pitié-Salpêtrière, 75013 Paris, France.

Online MALDI-TOF mass spectrometry applications, such as MSI-2, have been shown to help identify dermatophytes, but recurrent errors are still observed between phylogenetically close species. The objective of this study was to assess different approaches to reduce the occurrence of such errors by adding new reference spectra to the MSI-2 application. Nine libraries were set up, comprising an increasing number of spectra obtained from reference strains that were submitted to various culture durations on two distinct culture media: Sabouraud gentamicin chloramphenicol medium and IDFP Conidia medium.

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Article Synopsis
  • Aging negatively impacts naive T cell function, leading to poorer immune responses to new antigens in elderly individuals.
  • Research shows that elderly naive CD8 T cells are more likely to undergo cell death and struggle to proliferate when stimulated, linked to disrupted lipid metabolism and higher activation levels.
  • Treatments that improve lipid metabolism, like rosiglitazone, can enhance the immune response of these T cells, suggesting potential strategies to improve vaccine effectiveness in older adults against cancers and respiratory viruses.
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Discovering dominant tumor immune archetypes in a pan-cancer census.

Cell

January 2022

Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

Article Synopsis
  • Cancers can be very different from each other depending on where they start and their specific changes in genes.
  • * A research project at UCSF looked at 364 individual tumors from 12 types of cancer to find common patterns in how the immune system interacts with these tumors.
  • * The study found specific immune patterns (called archetypes) that can help doctors understand cancer better and figure out new ways to treat it.
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Cerebral Vein Thrombosis in the Antiphospholipid Syndrome: Analysis of a Series of 27 Patients and Review of the Literature.

Brain Sci

December 2021

French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Inserm UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Assistance Publique-Hôpitaux de Paris (APHP), Groupement Hospitalier Pitié-Salpêtrière, Sorbonne Université, 75013 Paris, France.

(1) Background: The Antiphospholipid Syndrome (APS) is a systemic autoimmune disorder characterized by arterial and/or venous thrombosis, pregnancy morbidity and raised titers of antiphospholipid antibodies. Cerebral vein thrombosis (CVT) is a rare form of cerebrovascular accident and an uncommon APS manifestation; the information in the literature about this feature consists of case reports and small case series. Our purpose is to describe the particular characteristics of CVT when occurs as part of the APS and compare our series with the patients published in the literature.

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[Bispecific antibodies: An old story with a bright future… with CAR-T cells!].

Bull Cancer

October 2021

Sorbonne université, laboratoire « Microenvironnement immunitaire et immunothérapie », Inserm U.1135, centre d'immunologie et des maladies infectieuses (CIMI-Paris), faculté de médecine, 91, boulevard de l'hôpital, 75013, Paris, France. Electronic address:

CAR-T cells originate from two different approaches, cellular immunotherapy based on tumor immunosurveillance by T lymphocytes, combined with molecular engineering of bispecific antibodies and antibody fragments. The latter makes it possible to retarget immune effector cytotoxic cells (such as NK cells and T lymphocytes) to tumor cells through the binding to tumor-associated antigens. We present herein the history of bispecific antibodies, highlighting how such antibodies played a major role in CAR-T cell development.

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Background: Nontuberculous mycobacteria (NTM) are increasingly identified in industrialized countries, and their role as pathogens is more frequently recognized. The relative prevalence of NTM strains shows an important geographical variability. Thus, establishing the local relative prevalence of NTM strains is relevant and useful for clinicians.

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