3 results match your criteria: "Centre d'Immunologie de Marseille-Luminy Marseille[Affiliation]"
COX-2 Inhibition Reduces Bacterial Burden in Draining Lymph Nodes.
Front Microbiol
December 2016
Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy Marseille, France.
is a Gram-negative facultative intracellular bacterium responsible for a chronic disease known as brucellosis, the most widespread re-emerging zoonosis worldwide. Establishment of a Th1-mediated immune response characterized by the production of IL-12 and IFNγ is essential to control the disease. Leukotrienes derived from arachidonic acid (AA) metabolism are known to negatively regulate a protective Th1 immune response against bacterial infections.
View Article and Find Full Text PDFBtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
Front Cell Infect Microbiol
December 2013
Aix-Marseille Univ UM 2, Centre d'Immunologie de Marseille-Luminy Marseille, France.
Article Synopsis
- Several bacterial pathogens have proteins with TIR domains that help them cause disease.
- A newly identified protein in Brucella, called BtpB, inhibits TLR signaling likely through MyD88, affecting immune responses.
- BtpB is important for Brucella's virulence and contributes to chronic brucellosis by interfering with host dendritic cell activation.
The design of programs for the control of endemies requires the knowledge of the principal factors that determine parasite transmission and infection levels in exposed populations. In the studies summarized in this article, the role of environmental and host specific factors in the infection by S. mansoni have been evaluated.
View Article and Find Full Text PDF