3 results match your criteria: "Centre d'Immuno-Pathologie[Affiliation]"
[Immunology and male hypofertility].
Rev Fr Gynecol Obstet
February 1989
Centre d'Immuno-Pathologie et l'Immunologie Expérimentale, l'INSERM (U 23), CNRS (UA 289), Hôpital Saint-Antoine, Paris.
In man, 3 to 15 p. cent of hypofertilities have been ascribed to an antisperm auto-immunization, consisting of antibodies against antigens located in the spermatozoid membrane. This autoimmunization may be triggered by traumatic or infectious processes in the genitalia which resulted in a massive reabsorption of these antigens.
View Article and Find Full Text PDFAntigen-specific modulation of graft-versus-host reactions by two distinct placental factors.
Scand J Immunol
December 1988
INSERM, Centre d'Immuno-Pathologie, Paris, France.
Article Synopsis
- Two distinct mouse placental fractions (PF), 40 kDa and 60 kDa, are shown to significantly modify immune responses in mice, with the former inhibiting and the latter enhancing platelet-forming cell (PFC) responses.
- The study investigates their effects on a local graft-versus-host reaction (LGVHR) after mice are primed with allogeneic cells in the presence of these PFs, revealing specific modulation of immune responses.
- The research also highlights the biochemical characteristics of the PFs, showing that the 40 kDa PF is a glycoprotein while the 60 kDa PF is likely not, and details a method for purifying these fractions using insolubilized lectins.
In vitro immunomodulatory effects of placental substances on preparatory MLR and resulting modifications of lymphocyte reactivities.
J Reprod Immunol
July 1987
Centre d'Immuno-Pathologie et d'Immunologie Expérimentale (INSERM U 23, CNRS UA 289), Hôpital Saint-Antoine, Paris, France.
The immunomodulatory effects of murine placental extracts (PE) were studied in vitro using mixed lymphocyte culture (MLC) and resulting cell-mediated lympholysis (CML). The results showed that preparative cultures in the presence of PE syngeneic to the responding cells led to a low secondary MLR response with a concomitant generation of suppressor cells. At the efferent phase, cells from the same preparative culture showed a weaker cytotoxic activity than controls cultured in the absence of extract.
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